| Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines KJ Hassett, KE Benenato, E Jacquinet, A Lee, A Woods, O Yuzhakov, ... Molecular Therapy-Nucleic Acids 15, 1-11, 2019 | 586 | 2019 |
| A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates KEB Staci Sabnis, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai ... Molecular Therapy, 2018 | 521 | 2018 |
| mRNA structure regulates protein expression through changes in functional half-life DM Mauger, BJ Cabral, V Presnyak, SV Su, DW Reid, B Goodman, K Link, ... Proceedings of the National Academy of Sciences 116 (48), 24075-24083, 2019 | 358 | 2019 |
| Human 5′ UTR design and variant effect prediction from a massively parallel translation assay PJ Sample, B Wang, DW Reid, V Presnyak, IJ McFadyen, DR Morris, ... Nature Biotechnology 37 (7), 803, 2019 | 255 | 2019 |
| A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino) dibenzo [b … W Li, J Li, Y Wu, J Wu, R Hotchandani, K Cunningham, I McFadyen, ... Journal of medicinal chemistry 52 (7), 1799-1802, 2009 | 111 | 2009 |
| Application of a high‐throughput screening procedure with PEG‐induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal … TJ Gibson, K Mccarty, IJ McFadyen, E Cash, P Dalmonte, KD Hinds, ... Journal of pharmaceutical sciences 100 (3), 1009-1021, 2011 | 102 | 2011 |
| Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio) RE Rodriguez, A Barrallo, F Garcia-Malvar, IJ McFadyen, ... Neuroscience letters 288 (3), 207-210, 2000 | 65 | 2000 |
| Towards ambient temperature-stable vaccines: The identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay LD Schlehuber, IJ McFadyen, Y Shu, J Carignan, WP Duprex, WR Forsyth, ... Vaccine 29 (31), 5031-5039, 2011 | 60 | 2011 |
| Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease P Martini, SG Hoge, K Benenato, V Presnyak, I McFadyen, ... US Patent 10,519,455, 2019 | 57 | 2019 |
| Polynucleotides encoding citrin for the treatment of Citrullinemia type 2 P Martini, S Hoge, K Benenato, V Presnyak, I McFadyen, ... US Patent 10,993,918, 2021 | 52 | 2021 |
| Polynucleotides encoding jagged1 for the treatment of alagille syndrome K Benenato, S Hoge, P Martini, I McFadyen, V Presnyak, D An, ... US Patent App. 16/302,607, 2019 | 52 | 2019 |
| Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models C Wang, IJ McFadyen, JR Traynor, HI Mosberg Bioorganic & medicinal chemistry letters 8 (19), 2685-2688, 1998 | 48 | 1998 |
| MRNA combination therapy for the treatment of cancer JP Frederick, S Hewitt, A Bai, SG Hoge, V Presnyak, I McFadyen, ... US Patent 10,335,486, 2019 | 47 | 2019 |
| Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors AM Gilbert, M Kirisits, P Toy, DS Nunn, A Failli, EG Dushin, E Novikova, ... Bioorganic & medicinal chemistry letters 14 (1), 37-41, 2004 | 44 | 2004 |
| Polynucleotides encoding porphobilinogen deaminase for the treatment of acute intermittent porphyria P Martini, S Hoge, K Benenato, V Presnyak, L Jiang, I McFadyen, ... US Patent App. 16/302,339, 2020 | 43 | 2020 |
| Polynucleotides Encoding Lipoprotein Lipase for the Treatment of Hyperlipidemia K Benenato, S Hoge, P Martini, I McFadyen, V Presnyak, ... US Patent App. 16/302,368, 2019 | 43 | 2019 |
| Polynucleotides Encoding Acyl-CoA Dehydrogenase, Very Long-Chain for the Treatment of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency P Martini, S Hoge, K Benenato, V Presnyak, I McFadyen, ... US Patent App. 16/302,298, 2019 | 43 | 2019 |
| POLYNUCLEOTIDE SECONDARY STRUCTURE D Mauger, I Mcfadyen, V Presnyak US Patent App. 16/483,012, 2020 | 42 | 2020 |
| Polynucleotides encoding relaxin B Ticho, N Briancon-Eris, Z Xia, A Dousis, S De Picciotto, V Presnyak, ... US Patent 10,730,924, 2020 | 40 | 2020 |
| A sensitivity analysis of RNA folding nearest neighbor parameters identifies a subset of free energy parameters with the greatest impact on RNA secondary structure prediction. J Zuber, H Sun, X Zhang, I McFadyen, D Mathews Nucleic Acids Research, 2017 | 40 | 2017 |
