| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694-699, 2004 | 2172 | 2004 |
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694-699, 2004 | 2172 | 2004 |
| Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non–small-cell lung cancer treated with chemotherapy … DA Eberhard, BE Johnson, LC Amler, AD Goddard, SL Heldens, ... Journal of clinical oncology 23 (25), 5900-5909, 2005 | 1834 | 2005 |
| RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth G Hatzivassiliou, K Song, I Yen, BJ Brandhuber, DJ Anderson, R Alvarado, ... Nature 464 (7287), 431-435, 2010 | 1808 | 2010 |
| Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma AG Uren, K O'Rourke, LA Aravind, MT Pisabarro, S Seshagiri, EV Koonin, ... Molecular cell 6 (4), 961-967, 2000 | 1321 | 2000 |
| Diverse somatic mutation patterns and pathway alterations in human cancers Z Kan, BS Jaiswal, J Stinson, V Janakiraman, D Bhatt, HM Stern, P Yue, ... Nature 466 (7308), 869-873, 2010 | 1197 | 2010 |
| Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer CM Rudin, S Durinck, EW Stawiski, JT Poirier, Z Modrusan, DS Shames, ... Nature genetics 44 (10), 1111-1116, 2012 | 1086 | 2012 |
| Recurrent R-spondin fusions in colon cancer S Seshagiri, EW Stawiski, S Durinck, Z Modrusan, EE Storm, CB Conboy, ... Nature 488 (7413), 660-664, 2012 | 1079 | 2012 |
| Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma RL Yauch, GJP Dijkgraaf, B Alicke, T Januario, CP Ahn, T Holcomb, ... Science 326 (5952), 572-574, 2009 | 1001 | 2009 |
| Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35 NJ Bump, M Hackett, M Hugunin, S Seshagiri, K Brady, P Chen, C Ferenz, ... Science 269 (5232), 1885-1888, 1995 | 894 | 1995 |
| Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ... Nature 471 (7336), 110-114, 2011 | 861 | 2011 |
| Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations R Bueno, EW Stawiski, LD Goldstein, S Durinck, A De Rienzo, ... Nature genetics 48 (4), 407-416, 2016 | 815 | 2016 |
| Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine … RS Herbst, DH Johnson, E Mininberg, DP Carbone, T Henderson, ES Kim, ... Journal of Clinical Oncology 23 (11), 2544-2555, 2005 | 701 | 2005 |
| Bcl10 activates the NF-κB pathway through ubiquitination of NEMO H Zhou, I Wertz, K O'Rourke, M Ultsch, S Seshagiri, M Eby, W Xiao, ... Nature 427 (6970), 167-171, 2004 | 682 | 2004 |
| A comprehensive transcriptional portrait of human cancer cell lines C Klijn, S Durinck, EW Stawiski, PM Haverty, Z Jiang, H Liu, J Degenhardt, ... Nature biotechnology 33 (3), 306-312, 2015 | 663 | 2015 |
| Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients RL Yauch, T Januario, DA Eberhard, G Cavet, W Zhu, L Fu, TQ Pham, ... Clinical Cancer Research 11 (24), 8686-8698, 2005 | 656 | 2005 |
| The mutation spectrum revealed by paired genome sequences from a lung cancer patient W Lee, Z Jiang, J Liu, PM Haverty, Y Guan, J Stinson, P Yue, Y Zhang, ... Nature 465 (7297), 473-477, 2010 | 630 | 2010 |
| The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer M O'hayre, J Vázquez-Prado, I Kufareva, EW Stawiski, TM Handel, ... Nature reviews cancer 13 (6), 412-424, 2013 | 567 | 2013 |
| A specificity map for the PDZ domain family R Tonikian, Y Zhang, SL Sazinsky, B Currell, JH Yeh, B Reva, HA Held, ... PLoS biology 6 (9), e239, 2008 | 563 | 2008 |
| Somatic mutations lead to an oncogenic deletion of met in lung cancer M Kong-Beltran, S Seshagiri, J Zha, W Zhu, K Bhawe, N Mendoza, ... Cancer research 66 (1), 283-289, 2006 | 541 | 2006 |
