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James Cantley
James Cantley
Bestätigte E-Mail-Adresse bei dundee.ac.uk - Startseite
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Jahr
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
J Cantley, FM Ashcroft
BMC biology 13, 1-7, 2015
1952015
G protein-coupled receptor (GPR) 40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1
M Ferdaoussi, V Bergeron, B Zarrouki, J Kolic, J Cantley, J Fielitz, ...
Diabetologia 55, 2682-2692, 2012
1772012
Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice
J Cantley, C Selman, D Shukla, AY Abramov, F Forstreuter, MA Esteban, ...
The Journal of clinical investigation 119 (1), 125-135, 2009
1442009
The hypoxia response pathway and β‐cell function
J Cantley, ST Grey, PH Maxwell, DJ Withers
Diabetes, Obesity and Metabolism 12, 159-167, 2010
1362010
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells
E Boslem, JM Weir, G MacIntosh, N Sue, J Cantley, PJ Meikle, TJ Biden
Journal of Biological Chemistry 288 (37), 26569-26582, 2013
1272013
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity
LE Wu, D Samocha-Bonet, PT Whitworth, DJ Fazakerley, N Turner, ...
Molecular metabolism 3 (4), 465-473, 2014
1112014
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
J Cantley, AI Choudhury, H Asare-Anane, C Selman, S Lingard, H Heffron, ...
Diabetologia 50, 1248-1256, 2007
992007
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis
J Cantley
Mammalian Genome 25, 442-454, 2014
902014
High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice
JG Burchfield, MA Kebede, CC Meoli, J Stöckli, PT Whitworth, AL Wright, ...
Journal of biological chemistry 293 (15), 5731-5745, 2018
802018
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
K Raddatz, N Turner, G Frangioudakis, BM Liao, DJ Pedersen, J Cantley, ...
Diabetologia 54, 1447-1456, 2011
752011
Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice
XY Zeng, YP Wang, J Cantley, TJ Iseli, JC Molero, BD Hegarty, ...
Public Library of Science 7 (7), e42115, 2012
732012
Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α)
LL Dunn, SMY Kong, S Tumanov, W Chen, J Cantley, A Ayer, GJ Maghzal, ...
Arteriosclerosis, thrombosis, and vascular biology 41 (1), 317-330, 2021
682021
Deletion of PKCε selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse β-cells
J Cantley, JG Burchfield, GL Pearson, C Schmitz-Peiffer, M Leitges, ...
Diabetes 58 (8), 1826-1834, 2009
652009
Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
EK Malle, NW Zammit, SN Walters, YC Koay, J Wu, BM Tan, ...
Journal of Experimental Medicine 212 (8), 1239-1254, 2015
592015
A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis
J Cantley, SN Walters, MH Jung, A Weinberg, MJ Cowley, PT Whitworth, ...
Cell transplantation 22 (11), 2147-2159, 2013
582013
Diabetes causes dysfunctional dopamine neurotransmission favoring nigrostriatal degeneration in mice
I Pérez‐Taboada, S Alberquilla, ED Martín, R Anand, S Vietti‐Michelina, ...
Movement disorders 35 (9), 1636-1648, 2020
522020
Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in female mice
YC Shi, K Loh, M Bensellam, K Lee, L Zhai, J Lau, J Cantley, J Luzuriaga, ...
Endocrinology 156 (9), 3122-3136, 2015
492015
Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells
GL Pearson, N Mellett, KY Chu, J Cantley, A Davenport, P Bourbon, ...
Diabetologia 57, 129-139, 2014
492014
DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake
J Li, J Cantley, JG Burchfield, CC Meoli, J Stöckli, PT Whitworth, H Pant, ...
Diabetologia 57, 2173-2182, 2014
462014
Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice
M Simmgen, C Knauf, M Lopez, AI Choudhury, M Charalambous, ...
Diabetologia 49, 552-561, 2006
442006
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