| A novel platform for the potentiation of therapeutic antibodies based on antigen-dependent formation of IgG hexamers at the cell surface RN de Jong, FJ Beurskens, S Verploegen, K Strumane, MD van Kampen, ... PLoS biology 14 (1), e1002344, 2016 | 201 | 2016 |
| Advances and challenges in analytical characterization of biotechnology products: mass spectrometry-based approaches to study properties and behavior of protein therapeutics IA Kaltashov, CE Bobst, RR Abzalimov, G Wang, B Baykal, S Wang Biotechnology advances 30 (1), 210-222, 2012 | 163 | 2012 |
| Molecular basis of assembly and activation of complement component C1 in complex with immunoglobulin G1 and antigen G Wang, RN de Jong, ETJ van den Bremer, FJ Beurskens, AF Labrijn, ... Molecular Cell 63 (1), 135-145, 2016 | 160 | 2016 |
| Tandem native mass-spectrometry on antibody–drug conjugates and submillion Da antibody–antigen protein assemblies on an Orbitrap EMR equipped with a high-mass quadrupole mass … A Dyachenko, G Wang, M Belov, A Makarov, RN De Jong, ... Analytical chemistry 87 (12), 6095-6102, 2015 | 98 | 2015 |
| Unraveling the macromolecular pathways of IgG oligomerization and complement activation on antigenic surfaces J Strasser, RN de Jong, FJ Beurskens, G Wang, AJR Heck, J Schuurman, ... Nano letters 19 (7), 4787-4796, 2019 | 94 | 2019 |
| RNA sequencing by direct tagmentation of RNA/DNA hybrids L Di, Y Fu, Y Sun, J Li, L Liu, J Yao, G Wang, Y Wu, K Lao, RW Lee, ... Proceedings of the National Academy of Sciences 117 (6), 2886-2893, 2020 | 89 | 2020 |
| Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation AR Cruz, MA Boer, J Strasser, SA Zwarthoff, FJ Beurskens, CJC de Haas, ... Proceedings of the National Academy of Sciences 118 (7), e2016772118, 2021 | 75 | 2021 |
| TREM-1 multimerization is essential for its activation on monocytes and neutrophils K Carrasco, A Boufenzer, L Jolly, H Le Cordier, G Wang, AJR Heck, ... Cellular & Molecular Immunology 16 (5), 460-472, 2019 | 71 | 2019 |
| High resolution capillary isoelectric focusing mass spectrometry analysis of peptides, proteins, and monoclonal antibodies with a flow-through microvial interface L Wang, T Bo, Z Zhang, G Wang, W Tong, D Da Yong Chen Analytical chemistry 90 (15), 9495-9503, 2018 | 58 | 2018 |
| Direct monitoring of heat-stressed biopolymers with temperature-controlled electrospray ionization mass spectrometry G Wang, RR Abzalimov, IA Kaltashov Analytical chemistry 83 (8), 2870-2876, 2011 | 57 | 2011 |
| Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches Y Yang, G Wang, T Song, CB Lebrilla, AJR Heck MAbs 9 (4), 638-645, 2017 | 55 | 2017 |
| Evaluation of electrospray ionization mass spectrometry as a tool for characterization of small soluble protein aggregates G Wang, AJ Johnson, IA Kaltashov Analytical chemistry 84 (3), 1718-1724, 2012 | 43 | 2012 |
| Enhancing accuracy in molecular weight determination of highly heterogeneously glycosylated proteins by native tandem mass spectrometry G Wang, RN de Jong, ETJ van den Bremer, PWHI Parren, AJR Heck Analytical chemistry 89 (9), 4793-4797, 2017 | 42 | 2017 |
| Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry G Wang, RR Abzalimov, CE Bobst, IA Kaltashov Proceedings of the National Academy of Sciences 110 (50), 20087-20092, 2013 | 41 | 2013 |
| How can native mass spectrometry contribute to characterization of biomacromolecular higher-order structure and interactions? W Tong, G Wang Methods 144, 3-13, 2018 | 35 | 2018 |
| Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics IA Kaltashov, CE Bobst, J Pawlowski, G Wang Journal of pharmaceutical and biomedical analysis 184, 113169, 2020 | 31 | 2020 |
| Approach to characterization of the higher order structure of disulfide-containing proteins using hydrogen/deuterium exchange and top-down mass spectrometry G Wang, IA Kaltashov Analytical chemistry 86 (15), 7293–7298, 2014 | 30 | 2014 |
| Differential hydrogen/deuterium exchange during proteoform separation enables characterization of conformational differences between coexisting protein states Y Shen, X Zhao, G Wang, DDY Chen Analytical chemistry 91 (6), 3805-3809, 2019 | 27 | 2019 |
| Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry G Wang, PV Bondarenko, IA Kaltashov Analyst 143 (3), 670-677, 2018 | 27 | 2018 |
| Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry B Qiu, J Liu, Z Qin, G Wang, H Luo Chemical communications, 2863-2865, 2009 | 26 | 2009 |
