Elizabeth A Sweeny
Elizabeth A Sweeny
Cleveland Clinic Lerner Research Institute
Verified email at ccf.org
Cited by
Cited by
Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains
L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
Cell 173 (3), 677-692. e20, 2018
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104
SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ...
Science 357 (6348), 273-279, 2017
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients
ME DeSantis, EH Leung, EA Sweeny, ME Jackrel, M Cushman-Nick, ...
Cell 151 (4), 778-793, 2012
A synergistic small-molecule combination directly eradicates diverse prion strain structures
BE Roberts, ML Duennwald, H Wang, C Chung, NP Lopreiato, ...
Nature chemical biology 5 (12), 936-946, 2009
Mechanistic and structural insights into the prion-disaggregase activity of Hsp104
EA Sweeny, J Shorter
Journal of molecular biology 428 (9), 1870-1885, 2016
The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation
EA Sweeny, ME Jackrel, MS Go, MA Sochor, BM Razzo, ME DeSantis, ...
Molecular cell 57 (5), 836-849, 2015
Formation of Nitrogenase NifDK Tetramers in the Mitochondria of Saccharomyces cerevisiae
S Burén, EM Young, EA Sweeny, G Lopez-Torrejón, M Veldhuizen, ...
ACS synthetic biology 6 (6), 1043-1055, 2017
Prion proteostasis: Hsp104 meets its supporting cast
EA Sweeny, J Shorter
Prion 2 (4), 135-140, 2008
Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells
EA Sweeny, AB Singh, R Chakravarti, O Martinez-Guzman, A Saini, ...
Journal of Biological Chemistry 293 (37), 14557-14568, 2018
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation
ME DeSantis, EA Sweeny, D Snead, EH Leung, MS Go, K Gupta, ...
Journal of Biological Chemistry 289 (2), 848-867, 2014
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells
A Ghosh, G Garee, EA Sweeny, Y Nakamura, DJ Stuehr
Proceedings of the National Academy of Sciences 115 (6), E1117-E1126, 2018
Purification of hsp104, a protein disaggregase
EA Sweeny, ME DeSantis, J Shorter
JoVE (Journal of Visualized Experiments), e3190, 2011
Mining disaggregase sequence space to safely counter TDP-43, FUS, and α-Synuclein proteotoxicity
A Tariq, JB Lin, ME Jackrel, CD Hesketh, PJ Carman, KL Mack, ...
Cell reports 28 (8), 2080-2095. e6, 2019
Avidity for polypeptide binding by nucleotide-bound Hsp104 structures
CL Weaver, EC Duran, KL Mack, JB Lin, ME Jackrel, EA Sweeny, ...
Biochemistry 56 (15), 2071-2075, 2017
GAPDH delivers heme to soluble guanylyl cyclase
Y Dai, EA Sweeny, S Schlanger, A Ghosh, DJ Stuehr
Journal of Biological Chemistry 295 (24), 8145-8154, 2020
Hsp104 and potentiated variants can operate as distinct nonprocessive translocases
CL Durie, JB Lin, NW Scull, KL Mack, ME Jackrel, EA Sweeny, ...
Biophysical journal 116 (10), 1856-1872, 2019
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting
EA Sweeny, A Tariq, E Gurpinar, MS Go, MA Sochor, ZY Kan, L Mayne, ...
Journal of Biological Chemistry 295 (6), 1517-1538, 2020
Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones
EA Sweeny, S Schlanger, DJ Stuehr
Redox biology 36, 101656, 2020
Dynamic Regulation of NADPH Oxidase 5 by Heme, Nitric oxide, and Hsp90
E Sweeny, A Hunt, S Schlanger, N Lehnert, D Stuehr
Free Radical Biology and Medicine 159, S33, 2020
Nuclear-import receptors reverse aberrant phase transitions of disease-linked RNA-binding proteins with prion-like domains.
L Guo, H Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ...
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