| The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 M Scheffner, BA Werness, JM Huibregtse, AJ Levine, PM Howley Cell 63 (6), 1129-1136, 1990 | 5294 | 1990 |
| The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 M Scheffner, JM Huibregtse, RD Vierstra, PM Howley Cell 75 (3), 495-505, 1993 | 3124 | 1993 |
| A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. JM Huibregtse, M Scheffner, S Beaudenon, PM Howley Proceedings of the National Academy of Sciences 92 (7), 2563-2567, 1995 | 1485 | 1995 |
| Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade M Scheffner, U Nuber, JM Huibregtse Nature 373 (6509), 81-83, 1995 | 1319 | 1995 |
| A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. JM Huibregtse, M Scheffner, PM Howley The EMBO journal 10 (13), 4129-4135, 1991 | 1144 | 1991 |
| The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. M Scheffner, K Münger, JC Byrne, PM Howley Proceedings of the National Academy of Sciences 88 (13), 5523-5527, 1991 | 1090 | 1991 |
| Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex Y Fujita, G Krause, M Scheffner, D Zechner, HEM Leddy, J Behrens, ... Nature cell biology 4 (3), 222-231, 2002 | 1037 | 2002 |
| Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. JM Huibregtse, M Scheffner, PM Howley Molecular and cellular biology 13 (2), 775-784, 1993 | 742 | 1993 |
| Activation of p53 by conjugation to the ubiquitin‐like protein SUMO‐1 M Gostissa, A Hengstermann, V Fogal, P Sandy, SE Schwarz, ... The EMBO journal 18 (22), 6462-6471, 1999 | 683 | 1999 |
| The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation S Adhikary, F Marinoni, A Hock, E Hulleman, N Popov, R Beier, S Bernard, ... Cell 123 (3), 409-421, 2005 | 562 | 2005 |
| Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. JM Huibregtse, M Scheffner, PM Howley Molecular and cellular biology 13 (8), 4918-4927, 1993 | 555 | 1993 |
| Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells T Rothmann, A Hengstermann, NJ Whitaker, M Scheffner, H zur Hausen Journal of virology 72 (12), 9470-9478, 1998 | 482 | 1998 |
| HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 LK Linares, A Hengstermann, A Ciechanover, S Müller, M Scheffner Proceedings of the National Academy of Sciences 100 (21), 12009-12014, 2003 | 459 | 2003 |
| siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells K Butz, T Ristriani, A Hengstermann, C Denk, M Scheffner, ... Oncogene 22 (38), 5938-5945, 2003 | 448 | 2003 |
| Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products. K Münger, M Scheffner, JM Huibregtse, PM Howley Cancer surveys 12, 197-217, 1992 | 412 | 1992 |
| Interaction between ubiquitin–protein ligase SCF SKP2 and E2F-1 underlies the regulation of E2F-1 degradation A Marti, C Wirbelauer, M Scheffner, W Krek Nature cell biology 1 (1), 14-19, 1999 | 401 | 1999 |
| RNA helicase activity associated with the human p68 protein H Hirling, M Scheffner, T Restle, H Stahl Nature 339 (6225), 562-564, 1989 | 385 | 1989 |
| Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53 M Scheffner, JM Huibregtse, PM Howley Proceedings of the National Academy of Sciences 91 (19), 8797-8801, 1994 | 361 | 1994 |
| Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects M Scheffner, S Kumar Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (1), 61-74, 2014 | 334 | 2014 |
| The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation C Esser, M Scheffner, J Höhfeld Journal of Biological Chemistry 280 (29), 27443-27448, 2005 | 308 | 2005 |
Jon HuibregtseUniversity of Texas at AustinBestätigte E-Mail-Adresse bei austin.utexas.edu
