Jan Molenaar
Jan Molenaar
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Verified email at prinsesmaximacentrum.nl
TitleCited byYear
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
JJ Molenaar, J Koster, DA Zwijnenburg, P van Sluis, LJ Valentijn, ...
Nature 483 (7391), 589-593, 2012
6362012
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
T Rausch, DTW Jones, M Zapatka, AM Stütz, T Zichner, J Weischenfeldt, ...
Cell 148 (1-2), 59-71, 2012
6102012
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
JJ Molenaar, R Domingo-Fernández, ME Ebus, S Lindner, J Koster, ...
Nature genetics 44 (11), 1199, 2012
2572012
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
TF Eleveld, DA Oldridge, V Bernard, J Koster, LC Daage, SJ Diskin, ...
Nature genetics 47 (8), 864, 2015
2532015
The landscape of genomic alterations across childhood cancers
SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter, K Kleinheinz, ...
Nature 555 (7696), 321-327, 2018
2362018
TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors
LJ Valentijn, J Koster, DA Zwijnenburg, NE Hasselt, P van Sluis, ...
Nature genetics 47 (12), 1411, 2015
1572015
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
LJ Valentijn, J Koster, F Haneveld, RA Aissa, P van Sluis, ...
Proceedings of the National Academy of Sciences 109 (47), 19190-19195, 2012
1502012
Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
JJ Molenaar, ME Ebus, J Koster, P van Sluis, CJM van Noesel, ...
Cancer research 68 (8), 2599-2609, 2008
1472008
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
JJ Molenaar, ME Ebus, D Geerts, J Koster, F Lamers, LJ Valentijn, ...
Proceedings of the National Academy of Sciences 106 (31), 12968-12973, 2009
1382009
ArrayCGH‐based classification of neuroblastoma into genomic subgroups
E Michels, J Vandesompele, K De Preter, J Hoebeeck, J Vermeulen, ...
Genes, Chromosomes and Cancer 46 (12), 1098-1108, 2007
832007
miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
K De Preter, P Mestdagh, J Vermeulen, F Zeka, A Naranjo, I Bray, ...
Clinical Cancer Research 17 (24), 7684-7692, 2011
782011
Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma
JJ Molenaar, P van Sluis, K Boon, R Versteeg, HN Caron
Genes, Chromosomes and Cancer 36 (3), 242-249, 2003
782003
Neuroblastoma is composed of two super-enhancer-associated differentiation states
T van Groningen, J Koster, LJ Valentijn, DA Zwijnenburg, N Akogul, ...
Nature genetics 49 (8), 1261, 2017
762017
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients
P Fardin, A Barla, S Mosci, L Rosasco, A Verri, R Versteeg, HN Caron, ...
Molecular cancer 9 (1), 185, 2010
762010
MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
JH Schulte, S Lindner, A Bohrer, J Maurer, K De Preter, S Lefever, ...
Oncogene 32 (8), 1059-1065, 2013
752013
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe
F Lamers, I Van Der Ploeg, L Schild, ME Ebus, J Koster, BR Hansen, ...
Endocrine Related Cancer 18 (6), 657, 2011
732011
Prevalence and clinical implications of chromothripsis in cancer genomes
WP Kloosterman, J Koster, JJ Molenaar
Current opinion in oncology 26 (1), 64-72, 2014
712014
miR‐542‐3p exerts tumor suppressive functions in neuroblastoma by downregulating S urvivin
K Althoff, S Lindner, A Odersky, P Mestdagh, A Beckers, S Karczewski, ...
International journal of cancer 136 (6), 1308-1320, 2015
632015
Microsatellite instability and frameshift mutations in BAX and transforming growth factor-β RII genes are very uncommon in acute lymphoblastic leukemia in vivo but not in cell …
JJ Molenaar, B Gérard, C Chambon-Pautas, H Cavé, M Duval, E Vilmer, ...
Blood, The Journal of the American Society of Hematology 92 (1), 230-233, 1998
631998
Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis
JJ Molenaar, J Koster, ME Ebus, P van Sluis, EM Westerhout, K De Preter, ...
Genes, Chromosomes and Cancer 51 (1), 10-19, 2012
562012
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