Steve Withers
Steve Withers
Professor of Chemistry and Biochemistry, University Of British Columbia
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Glycosyltransferases: structures, functions, and mechanisms
LL Lairson, B Henrissat, GJ Davies, SG Withers
Annu. Rev. Biochem. 77 (1), 521-555, 2008
Glycosidase mechanisms: anatomy of a finely tuned catalyst
DL Zechel, SG Withers
Accounts of chemical research 33 (1), 11-18, 2000
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
DJ Vocadlo, GJ Davies, R Laine, SG Withers
Nature 412 (6849), 835-838, 2001
Glycosidase mechanisms
CS Rye, SG Withers
Current opinion in chemical biology 4 (5), 573-580, 2000
Glycosynthases: mutant glycosidases for oligosaccharide synthesis
LF Mackenzie, Q Wang, RAJ Warren, SG Withers
Journal of the American Chemical Society 120 (22), 5583-5584, 1998
X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the α-amylase family
J Uitdehaag, R Mosi, KH Kalk, BA van der Veen, L Dijkhuizen, SG Withers, ...
nature structural biology 6 (5), 432-436, 1999
The structure of human pancreatic α‐amylase at 1.8 Ċ resolution and comparisons with related enzymes
GD Brayer, Y Luo, SG Withers
Protein Science 4 (9), 1730-1742, 1995
Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs
K Persson, HD Ly, M Dieckelmann, WW Wakarchuk, SG Withers, ...
Nature structural biology 8 (2), 166-175, 2001
Mechanism of Agrobacterium. beta.-glucosidase: kinetic studies
JB Kempton, SG Withers
Biochemistry 31 (41), 9961-9969, 1992
Crystallographic evidence for substrate-assisted catalysis in a bacterial β-hexosaminidase
BL Mark, DJ Vocadlo, S Knapp, BL Triggs-Raine, SG Withers, ...
Journal of Biological Chemistry 276 (13), 10330-10337, 2001
The pKa of the General Acid/Base Carboxyl Group of a Glycosidase Cycles during Catalysis:  A 13C-NMR Study of Bacillus circulans Xylanase
LP McIntosh, G Hand, PE Johnson, MD Joshi, M Körner, LA Plesniak, ...
Biochemistry 35 (31), 9958-9966, 1996
NAG-thiazoline, an N-acetyl-β-hexosaminidase inhibitor that implicates acetamido participation
S Knapp, D Vocadlo, Z Gao, B Kirk, J Lou, SG Withers
Journal of the American Chemical Society 118 (28), 6804-6805, 1996
Mutagenesis of glycosidases
HD Ly, SG Withers
Annual review of biochemistry 68 (1), 487-522, 1999
Snapshots along an Enzymatic Reaction Coordinate:  Analysis of a Retaining β-Glycoside Hydrolase,
GJ Davies, L Mackenzie, A Varrot, M Dauter, AM Brzozowski, M Schülein, ...
Biochemistry 37 (34), 11707-11713, 1998
Engineering of glycosidases and glycosyltransferases
SM Hancock, MD Vaughan, SG Withers
Current opinion in chemical biology 10 (5), 509-519, 2006
Stereoselective hydrolysis catalyzed by related beta-1, 4-glucanases and beta-1, 4-xylanases.
J Gebler, NR Gilkes, M Claeyssens, DB Wilson, P Beguin, ...
Journal of Biological Chemistry 267 (18), 12559-12561, 1992
Subsite Mapping of the Human Pancreatic α-Amylase Active Site through Structural, Kinetic, and Mutagenesis Techniques,
GD Brayer, G Sidhu, R Maurus, EH Rydberg, C Braun, Y Wang, ...
Biochemistry 39 (16), 4778-4791, 2000
Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a retaining glycosidase
SG Withers, RAJ Warren, IP Street, K Rupitz, JB Kempton, R Aebersold
Journal of the American Chemical Society 112 (15), 5887-5889, 1990
Mechanisms of glycosyl transferases and hydrolases
SG Withers
Carbohydrate polymers 44 (4), 325-337, 2001
Glycosyl fluorides in enzymatic reactions
SJ Williams, SG Withers
Carbohydrate research 327 (1-2), 27-46, 2000
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