| Uncovering the hidden antibiotic potential of cannabis MA Farha, OM El-Halfawy, RT Gale, CR MacNair, LA Carfrae, X Zhang, ... ACS infectious diseases 6 (3), 338-346, 2020 | 113 | 2020 |
| Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance S Sobhanifar, LJ Worrall, DT King, GA Wasney, L Baumann, RT Gale, ... PLoS pathogens 12 (12), e1006067, 2016 | 51 | 2016 |
| PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR‐mediated phosphate … E Botella, SK Devine, S Hubner, LI Salzberg, RT Gale, ED Brown, H Link, ... Molecular microbiology 94 (6), 1242-1259, 2014 | 43 | 2014 |
| Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria MD Kattke, JE Gosschalk, OE Martinez, G Kumar, RT Gale, D Cascio, ... PLoS Pathogens 15 (4), e1007723, 2019 | 33 | 2019 |
| B. subtilis LytR-CpsA-Psr enzymes transfer wall teichoic acids from authentic lipid-linked substrates to mature peptidoglycan in vitro RT Gale, FKK Li, T Sun, NCJ Strynadka, ED Brown Cell chemical biology 24 (12), 1537-1546. e4, 2017 | 31 | 2017 |
| Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites MA Farha, K Koteva, RT Gale, EW Sewell, GD Wright, ED Brown Bioorganic & medicinal chemistry letters 24 (3), 905-910, 2014 | 29 | 2014 |
| Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase FKK Li, FI Rosell, RT Gale, JP Simorre, ED Brown, NCJ Strynadka Journal of Biological Chemistry 295 (9), 2629-2639, 2020 | 22 | 2020 |
| New chemical tools to probe cell wall biosynthesis in bacteria RT Gale, ED Brown Current opinion in microbiology 27, 69-77, 2015 | 18 | 2015 |
| Reconstituting poly (glycerol phosphate) wall teichoic acid biosynthesis in vitro using authentic substrates RT Gale, EW Sewell, TA Garrett, ED Brown Chemical Science 5 (10), 3823-3830, 2014 | 17 | 2014 |
| Uncovering the hidden antibiotic potential of Cannabis. BioRxiv, 833392 MA Farha, OM El-Halfawy, RT Gale, CR MacNair, LA Carfrae, X Zhang, ... | 5 | 2020 |
| Synthetic Antibacterial Compounds and Uses Thereof E Brown, OM Elhalfawy, M Farha, J Magolan, R Gale US Patent App. 17/296,080, 2022 | 1 | 2022 |
| Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis FKK Li, RT Gale, EV Petrotchenko, CH Borchers, ED Brown, ... Journal of Structural Biology 213 (2), 107733, 2021 | 1 | 2021 |
| Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance FKK Li, LJ Worrall, RT Gale, ED Brown, NCJ Strynadka Science Advances 10 (9), eadj3864, 2024 | | 2024 |
| USING AUTHENTIC SUBSTRATES TO PROBE WALL TEICHOIC ACID ASSEMBLY RT Gale | | 2018 |
| Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase Franco KK Li1, 2, Federico I. Rosell1, 2, Robert T. Gale3, Jean-Pierre Simorre4 … FKK Li, FI Rosell, RT Gale, JP Simorre, ED Brown | | |
Eric D BrownProfessor of Biochemistry, McMaster UniversityVerified email at mcmaster.ca
