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David J. Polhemus MD, PhD
David J. Polhemus MD, PhD
The Johns Hopkins Hospital
Verified email at jh.edu
Title
Cited by
Cited by
Year
Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease
DJ Polhemus, DJ Lefer
Circulation research 114 (4), 730-737, 2014
4922014
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent
AL King, DJ Polhemus, S Bhushan, H Otsuka, K Kondo, CK Nicholson, ...
Proceedings of the National Academy of Sciences 111 (8), 3182-3187, 2014
3802014
Choline diet and its gut microbe–derived metabolite, trimethylamine N-oxide, exacerbate pressure overload–induced heart failure
CL Organ, H Otsuka, S Bhushan, Z Wang, J Bradley, R Trivedi, ...
Circulation: Heart Failure 9 (1), e002314, 2016
3342016
Hydrogen sulfide attenuates cardiac dysfunction after heart failure via induction of angiogenesis
DJ Polhemus, K Kondo, S Bhushan, SC Bir, CG Kevil, T Murohara, ...
Circulation: Heart Failure 6 (5), 1077-1086, 2013
1782013
A novel hydrogen sulfide prodrug, SG 1002, promotes hydrogen sulfide and nitric oxide bioavailability in heart failure patients
DJ Polhemus, Z Li, CB Pattillo, G Gojon Sr, G Gojon Jr, T Giordano, ...
Cardiovascular therapeutics 33 (4), 216-226, 2015
1542015
Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease
Z Li, DJ Polhemus, DJ Lefer
Circulation Research 123 (5), 590-600, 2018
1102018
The cardioprotective actions of hydrogen sulfide in acute myocardial infarction and heart failure
DJ Polhemus, JW Calvert, J Butler, DJ Lefer
Scientifica 2014, 2014
1082014
Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system
TE Sharp III, DJ Polhemus, Z Li, P Spaletra, JS Jenkins, JP Reilly, ...
Journal of the American College of Cardiology 72 (21), 2609-2621, 2018
892018
Renal sympathetic denervation protects the failing heart via inhibition of neprilysin activity in the kidney
DJ Polhemus, RK Trivedi, J Gao, Z Li, AL Scarborough, TT Goodchild, ...
Journal of the American College of Cardiology 70 (17), 2139-2153, 2017
812017
Nitrite therapy improves left ventricular function during heart failure via restoration of nitric oxide–mediated cytoprotective signaling
S Bhushan, K Kondo, DJ Polhemus, H Otsuka, CK Nicholson, YX Tao, ...
Circulation research 114 (8), 1281-1291, 2014
742014
Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure
CL Organ, Z Li, TE Sharp III, DJ Polhemus, N Gupta, TT Goodchild, ...
Journal of the American Heart Association 9 (10), e016223, 2020
722020
Zofenopril protects against myocardial ischemia–reperfusion injury by increasing nitric oxide and hydrogen sulfide bioavailability
E Donnarumma, MJ Ali, AM Rushing, AL Scarborough, JM Bradley, ...
Journal of the American Heart Association 5 (7), e003531, 2016
652016
Hydrogen Sulfide Levels and Nuclear Factor‐Erythroid 2‐Related Factor 2 (NRF 2) Activity Are Attenuated in the Setting of Critical Limb Ischemia (CLI)
KN Islam, DJ Polhemus, E Donnarumma, LP Brewster, DJ Lefer
Journal of the American Heart Association 4 (5), e001986, 2015
592015
Combined angiotensin receptor–neprilysin inhibitors improve cardiac and vascular function via increased no bioavailability in heart failure
RK Trivedi, DJ Polhemus, Z Li, D Yoo, H Koiwaya, A Scarborough, ...
Journal of the American Heart Association 7 (5), e008268, 2018
522018
Restoration of hydrogen sulfide production in diabetic mice improves reparative function of bone marrow cells
Z Cheng, VNS Garikipati, E Nickoloff, C Wang, DJ Polhemus, J Zhou, ...
Circulation 134 (19), 1467-1483, 2016
492016
Radiofrequency renal denervation protects the ischemic heart via inhibition of GRK2 and increased nitric oxide signaling
DJ Polhemus, J Gao, AL Scarborough, R Trivedi, KH McDonough, ...
Circulation research 119 (3), 470-480, 2016
482016
Effects of storage‐aged red blood cell transfusions on endothelial function in hospitalized patients
R Neuman, S Hayek, A Rahman, JC Poole, V Menon, S Sher, JL Newman, ...
Transfusion 55 (4), 782-790, 2015
472015
Hydrogen sulfide attenuates renin angiotensin and aldosterone pathological signaling to preserve kidney function and improve exercise tolerance in heart failure
Z Li, CL Organ, J Kang, DJ Polhemus, RK Trivedi, TE Sharp, JS Jenkins, ...
JACC: Basic to Translational Science 3 (6), 796-809, 2018
362018
Novel Göttingen miniswine model of heart failure with preserved ejection fraction integrating multiple comorbidities
TE Sharp III, AL Scarborough, Z Li, DJ Polhemus, HA Hidalgo, ...
Basic to Translational Science 6 (2), 154-170, 2021
312021
Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia
AM Rushing, E Donnarumma, DJ Polhemus, KR Au, SE Victoria, ...
Journal of vascular surgery 69 (6), 1924-1935, 2019
312019
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