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George J Yohrling
George J Yohrling
Chief Scientific Officer and Chief Mission Officer, Huntington's Disease Society of America
Bestätigte E-Mail-Adresse bei hdsa.org - Startseite
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Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner
CL Benn, T Sun, G Sadri-Vakili, KN McFarland, DP DiRocco, GJ Yohrling, ...
Journal of Neuroscience 28 (42), 10720-10733, 2008
2782008
Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models
G Sadri-Vakili, B Bouzou, CL Benn, MO Kim, P Chawla, RP Overland, ...
Human molecular genetics 16 (11), 1293-1306, 2007
2392007
Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
AS Chen-Plotkin, G Sadri-Vakili, GJ Yohrling, MW Braveman, CL Benn, ...
Neurobiology of disease 22 (2), 233-241, 2006
1382006
Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology
GJ Yohrling IV, GCT Jiang, MM DeJohn, DW Miller, AB Young, KE Vrana, ...
Molecular Brain Research 119 (1), 28-36, 2003
792003
Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
N Carty, N Berson, K Tillack, C Thiede, D Scholz, K Kottig, Y Sedaghat, ...
PloS one 10 (4), e0123527, 2015
752015
Inhibition of tryptophan hydroxylase activity and decreased 5‐HT1A receptor binding in a mouse model of Huntington's disease
GJ Yohrling Iv, GCT Jiang, MM DeJohn, DJ Robertson, KE Vrana, ...
Journal of neurochemistry 82 (6), 1416-1423, 2002
652002
Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling
GCT Jiang, GJ Yohrling, I Schmitt, KE Vrana
Journal of molecular biology 302 (4), 1005-1017, 2000
532000
Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation
GJ Yohrling IV, LA Farrell, AN Hollenberg, JHJ Cha
Molecular and Cellular Neuroscience 23 (1), 28-38, 2003
502003
Striatal synaptosomes from Hdh 140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation
A Valencia, E Sapp, JS Kimm, H McClory, KA Ansong, G Yohrling, S Kwak, ...
Journal of Huntington's disease 2 (4), 459-475, 2013
472013
Survey of the Huntington’s disease patient and caregiver community reveals most impactful symptoms and treatment needs
JA Simpson, D Lovecky, J Kogan, LA Vetter, GJ Yohrling
Journal of Huntington's disease 5 (4), 395-403, 2016
462016
Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons
Y Liu, GJ Yohrling, Y Wang, TL Hutchinson, DE Brenneman, CM Flores, ...
Epilepsy research 83 (1), 66-72, 2009
432009
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads
Y Huang, ED Strobel, CY Ho, CH Reynolds, KA Conway, JA Piesvaux, ...
Bioorganic & medicinal chemistry letters 20 (10), 3158-3160, 2010
362010
Huntingtin inclusions do not down‐regulate specific genes in the R6/2 Huntington's disease mouse
G Sadri‐Vakili, AS Menon, LA Farrell, CE Keller‐McGandy, ...
European Journal of Neuroscience 23 (12), 3171-3175, 2006
312006
Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain
MW Braveman, AS Chen-Plotkin, GJ Yohrling, JHJ Cha
Trinucleotide Repeat Protocols, 261-276, 2004
222004
Volumetric MRI-based biomarkers in Huntington's disease: an evidentiary review
KM Kinnunen, AJ Schwarz, EC Turner, D Pustina, EC Gantman, ...
Frontiers in Neurology 12, 712555, 2021
202021
Neurochemistry of Huntington's disease
GJ Yohrling, JHJ Cha
OXFORD MONOGRAPHS ON MEDICAL GENETICS 45, 276-308, 2002
192002
Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase
GJ Yohrling IV, GCT Jiang, SM Mockus, KE Vrana
Journal of neuroscience research 61 (3), 313-320, 2000
162000
Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation
GJ Yohrling, SM Mockus, KE Vrana
Journal of Molecular Neuroscience 12, 23-34, 1999
151999
Prevalence of Huntington’s disease in the US (954)
G Yohrling, K Raimundo, V Crowell, D Lovecky, L Vetter, L Seeberger
Neurology 94 (15 Supplement), 2020
132020
Epidemiology of Huntington’s disease (HD) in the US medicare population (670)
A Exuzides, V Crowell, SR Reddy, E Chang, G Yohrling
Neurology 94 (15 Supplement), 2020
112020
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