| MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates Y Dondelinger, W Declercq, S Montessuit, R Roelandt, A Goncalves, ... Cell reports 7 (4), 971-981, 2014 | 815 | 2014 |
| Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system HJ Yeo, SN Savvides, AB Herr, E Lanka, G Waksman Molecular cell 6 (6), 1461-1472, 2000 | 272 | 2000 |
| Protein crystallization promotes type 2 immunity and is reversible by antibody treatment EK Persson, K Verstraete, I Heyndrickx, E Gevaert, H Aegerter, JM Percier, ... Science 364 (6442), eaaw4295, 2019 | 233 | 2019 |
| Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ... Cell 170 (3), 443-456. e14, 2017 | 231 | 2017 |
| VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion SN Savvides, HJ Yeo, MR Beck, F Blaesing, R Lurz, E Lanka, R Buhrdorf, ... The EMBO journal, 2003 | 229 | 2003 |
| Design of protein-binding proteins from the target structure alone L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ... Nature 605 (7910), 551-560, 2022 | 218 | 2022 |
| Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers K Becker, SN Savvides, M Keese, RH Schirmer, PA Karplus Nature Structural Biology 5 (4), 267-271, 1998 | 191 | 1998 |
| Glutathione reductase of the malarial parasite Plasmodium falciparum: crystal structure and inhibitor development GN Sarma, SN Savvides, K Becker, M Schirmer, RH Schirmer, PA Karplus Journal of molecular biology 328 (4), 893-907, 2003 | 177 | 2003 |
| Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite SN Savvides, M Scheiwein, CC Bohme, GE Arteel, PA Karplus, K Becker, ... Journal of Biological Chemistry 277 (4), 2779-2784, 2002 | 163 | 2002 |
| The C‐terminal domain of full‐length E. coli SSB is disordered even when bound to DNA SN Savvides, S Raghunathan, K Fütterer, AG Kozlov, TM Lohman, ... Protein Science 13 (7), 1942-1947, 2004 | 161 | 2004 |
| Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma K Verstraete, F Peelman, H Braun, J Lopez, D Van Rompaey, ... Nature communications 8 (1), 14937, 2017 | 145 | 2017 |
| Catalytic cycle of human glutathione reductase near 1 Å resolution DS Berkholz, HR Faber, SN Savvides, PA Karplus Journal of molecular biology 382 (2), 371-384, 2008 | 144 | 2008 |
| Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation Y Dondelinger, T Delanghe, D Priem, MA Wynosky-Dolfi, D Sorobetea, ... Nature communications 10 (1), 1729, 2019 | 141 | 2019 |
| Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms BH Durham, E Lopez Rodrigo, J Picarsic, D Abramson, V Rotemberg, ... Nature medicine 25 (12), 1839-1842, 2019 | 138 | 2019 |
| Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells S Liénart, R Merceron, C Vanderaa, F Lambert, D Colau, J Stockis, ... Science 362 (6417), 952-956, 2018 | 133 | 2018 |
| Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle KHG Verschueren, C Blanchet, J Felix, A Dansercoer, D De Vos, Y Bloch, ... Nature 568 (7753), 571-575, 2019 | 127 | 2019 |
| Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 Y Bloch, L Bouchareychas, R Merceron, K Składanowska, ... Immunity 48 (1), 45-58. e6, 2018 | 108 | 2018 |
| Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase JA Ponasik, C Strickland, C Faerman, S Savvides, PA Karplus, B Ganem Biochemical Journal 311 (2), 371-375, 1995 | 106 | 1995 |
| Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor SN Savvides, PA Karplus Journal of Biological Chemistry 271 (14), 8101-8107, 1996 | 105 | 1996 |
| Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex K Verstraete, G Vandriessche, M Januar, J Elegheert, AV Shkumatov, ... Blood, The Journal of the American Society of Hematology 118 (1), 60-68, 2011 | 99 | 2011 |
Kenneth VerstraeteFlanders Institute for Biotechnology and Ghent University, BelgiumBestätigte E-Mail-Adresse bei ugent.be
