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Wing Lee Chan
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Formation of new chromatin domains determines pathogenicity of genomic duplications
M Franke, DM Ibrahim, G Andrey, W Schwarzer, V Heinrich, R Schöpflin, ...
Nature 538 (7624), 265-269, 2016
6582016
Functional dissection of the Sox9–Kcnj2 locus identifies nonessential and instructive roles of TAD architecture
A Despang, R Schöpflin, M Franke, S Ali, I Jerković, C Paliou, WL Chan, ...
Nature genetics 51 (8), 1263-1271, 2019
2492019
Deletions, inversions, duplications: engineering of structural variants using CRISPR/Cas in mice
K Kraft, S Geuer, AJ Will, WL Chan, C Paliou, M Borschiwer, I Harabula, ...
Cell reports 10 (5), 833-839, 2015
2352015
Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis
BK Kragesteen, M Spielmann, C Paliou, V Heinrich, R Schöpflin, ...
Nature genetics 50 (10), 1463-1473, 2018
1682018
Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)
AJ Will, G Cova, M Osterwalder, WL Chan, L Wittler, N Brieske, V Heinrich, ...
Nature genetics 49 (10), 1539-1545, 2017
1102017
Secretion of beta-propeller phytase from tobacco and Arabidopsis roots enhances phosphorus utilization
SC Lung, WL Chan, W Yip, L Wang, EC Yeung, BL Lim
Plant science 169 (2), 341-349, 2005
1052005
Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator
L Allou, S Balzano, A Magg, M Quinodoz, B Royer-Bertrand, R Schöpflin, ...
Nature 592 (7852), 93-98, 2021
882021
Transport activity and presence of ClC‐7/Ostm1 complex account for different cellular functions
S Weinert, S Jabs, S Hohensee, WL Chan, U Kornak, TJ Jentsch
EMBO reports 15 (7), 784-791, 2014
622014
Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice
M Spielmann, N Kakar, N Tayebi, C Leettola, G Nürnberg, N Sowada, ...
Genome research 26 (2), 183-191, 2016
612016
Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia …
WL Chan, M Steiner, T Witkos, J Egerer, B Busse, S Mizumoto, JM Pestka, ...
PLoS genetics 14 (3), e1007242, 2018
522018
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation
TM Witkos, WL Chan, M Joensuu, M Rhiel, E Pallister, J Thomas-Oates, ...
Nature communications 10 (1), 1-18, 2019
442019
GORAB missense mutations disrupt RAB6 and ARF5 binding and golgi targeting
J Egerer, D Emmerich, B Fischer-Zirnsak, WL Chan, D Meierhofer, ...
Journal of Investigative Dermatology 135 (10), 2368-2376, 2015
392015
Properties of beta-propeller phytase expressed in transgenic tobacco
WL Chan, SC Lung, BL Lim
Protein expression and purification 46 (1), 100-106, 2006
242006
Examining tissue composition, whole-bone morphology and mechanical behavior of GorabPrx1 mice tibiae: A mouse model of premature aging
H Yang, L Albiol, WL Chan, D Wulsten, A Seliger, M Thelen, T Thiele, ...
Journal of biomechanics 65, 145-153, 2017
232017
Functional dissection of TADs reveals non-essential and instructive roles in regulating gene expression
A Despang, R Schöpflin, M Franke, S Ali, I Jerkovic, C Paliou, WL Chan, ...
Cold Spring Harbor Laboratory, 2019
132019
GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation. Nature Communications
TM Witkos, WL Chan, M Joensuu, M Rhiel, E Pallister, J Thomas-Oates, ...
Nature Publishing Group, 2019
12019
Altered bone formation response to mechanical loading in a mouse model of the progeroid disorder gerodermia osteodysplastica
H Yang, A Seliger, M Thelen, WL Chan, U Kornak, BM Willie
1*
TGF-β induced senescence is a novel therapeutic target for treating osteoporosis in Gerodermia Osteodysplastica
WL Chan, J Goldes, M Steiner, AC Ma, S Mundlos, U Kornak
Bone Reports 13, 100621, 2020
2020
The effect of a deteriorated architecture of the lacunocanalicular network on the organization and mineralization of the extracellular matrix
A Roschger, AF van Tol, M Thelen, A Seliger, H Yang, WL Chan, T Thiele, ...
Bone Reports 13, 100396, 2020
2020
Loss of MAENLI, a newly characterized lncRNA, results in limb specific inactivation of EN1 and a dorsal dimelia limb phenotype
L Allou, S Balzano, A Magg, M Quinodoz, B Royer-Bertrand, R Schoepflin, ...
EUROPEAN JOURNAL OF HUMAN GENETICS 27, 1046-1047, 2019
2019
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