|Inflammation and insulin resistance|
SE Shoelson, J Lee, AB Goldfine
The Journal of clinical investigation 116 (7), 1793-1801, 2006
|SH2 domains recognize specific phosphopeptide sequences|
S Zhou, SE Shoelson, M Chaudhuri, G Gish, T Pawson, WG Haser, F King, ...
Cell 72 (5), 767-778, 1993
|Type 2 diabetes as an inflammatory disease|
MY Donath, SE Shoelson
Nature Reviews Immunology 11 (2), 98-107, 2011
|Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB|
D Cai, M Yuan, DF Frantz, PA Melendez, L Hansen, J Lee, SE Shoelson
Nature medicine 11 (2), 183-190, 2005
|Backbone dynamics of a free and a phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation|
NA Farrow, R Muhandiram, AU Singer, SM Pascal, CM Kay, G Gish, ...
Biochemistry 33 (19), 5984-6003, 1994
|Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ|
M Yuan, N Konstantopoulos, J Lee, L Hansen, ZW Li, M Karin, ...
Science 293 (5535), 1673-1677, 2001
|Obesity, inflammation, and insulin resistance|
SE Shoelson, L Herrero, A Naaz
Gastroenterology 132 (6), 2169-2180, 2007
|Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters|
M Feuerer, L Herrero, D Cipolletta, A Naaz, J Wong, A Nayer, J Lee, ...
Nature medicine 15 (8), 930, 2009
|IKKβ/NF-κB activation causes severe muscle wasting in mice|
D Cai, JD Frantz, NE Tawa Jr, PA Melendez, BC Oh, HGW Lidov, ...
Cell 119 (2), 285-298, 2004
|Identification of SOCS-3 as a potential mediator of central leptin resistance|
C Bjørbæk, JK Elmquist, JD Frantz, SE Shoelson, JS Flier
Molecular cell 1 (4), 619-625, 1998
|Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action|
V Aguirre, ED Werner, J Giraud, YH Lee, SE Shoelson, MF White
Journal of Biological Chemistry 277 (2), 1531-1537, 2002
|Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.|
S Zhou, SE Shoelson, J McGlade, P Olivier, T Pawson, XR Bustelo, ...
Molecular and Cellular Biology 14 (4), 2777-2785, 1994
|Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.|
JM Backer, MG Myers, SE Shoelson, DJ Chin, XJ Sun, M Miralpeix, P Hu, ...
The EMBO journal 11 (9), 3469-3479, 1992
|SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2|
L Rui, M Yuan, D Frantz, S Shoelson, MF White
Journal of Biological Chemistry 277 (44), 42394-42398, 2002
|Prevention of fat-induced insulin resistance by salicylate|
JK Kim, YJ Kim, JJ Fillmore, Y Chen, I Moore, J Lee, M Yuan, ZW Li, ...
The Journal of clinical investigation 108 (3), 437-446, 2001
|Regulation of inositol phospholipid-specific phospholipase C isozymes|
SG Rhee, KD Choi, G Pan, PD Sadowski, RM Wynn, JR Davie, RP Cox, ...
Regulation 267 (18), 1992
|Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide free forms|
G Waksman, SE Shoelson, N Pant, D Cowburn, J Kuriyan
Cell 72, 779-790, 1993
|Crystal structure of the tyrosine phosphatase SHP-2|
P Hof, S Pluskey, S Dhe-Paganon, MJ Eck, SE Shoelson
Cell 92 (4), 441-450, 1998
|Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes|
RS Hundal, KF Petersen, AB Mayerson, PS Randhawa, S Inzucchi, ...
The Journal of clinical investigation 109 (10), 1321-1326, 2002
|PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue T reg cells|
D Cipolletta, M Feuerer, A Li, N Kamei, J Lee, SE Shoelson, C Benoist, ...
Nature 486 (7404), 549-553, 2012