The death domain kinase RIP mediates the TNF-induced NF-κB signal MA Kelliher, S Grimm, Y Ishida, F Kuo, BZ Stanger, P Leder Immunity 8 (3), 297-303, 1998 | 1362 | 1998 |
RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation E Meylan, K Burns, K Hofmann, V Blancheteau, F Martinon, M Kelliher, ... Nature immunology 5 (5), 503-507, 2004 | 1117 | 2004 |
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death P Orning, D Weng, K Starheim, D Ratner, Z Best, B Lee, A Brooks, S Xia, ... Science 362 (6418), 1064-1069, 2018 | 745 | 2018 |
Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. MA Kelliher, J McLaughlin, ON Witte, N Rosenberg Proceedings of the National Academy of Sciences 87 (17), 6649-6653, 1990 | 682 | 1990 |
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer AL Wolfe, K Singh, Y Zhong, P Drewe, VK Rajasekhar, VR Sanghvi, ... Nature 513 (7516), 65-70, 2014 | 630 | 2014 |
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation A Devin, A Cook, Y Lin, Y Rodriguez, M Kelliher, Z Liu Immunity 12 (4), 419-429, 2000 | 627 | 2000 |
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3 CP Dillon, R Weinlich, DA Rodriguez, JG Cripps, G Quarato, P Gurung, ... Cell 157 (5), 1189-1202, 2014 | 562 | 2014 |
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS Y Ito, D Ofengeim, A Najafov, S Das, S Saberi, Y Li, J Hitomi, H Zhu, ... Science 353 (6299), 603-608, 2016 | 524 | 2016 |
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis M Dannappel, K Vlantis, S Kumari, A Polykratis, C Kim, L Wachsmuth, ... Nature 513 (7516), 90-94, 2014 | 512 | 2014 |
Rip1 mediates the Trif-dependent toll-like receptor 3-and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation N Cusson-Hermance, S Khurana, TH Lee, KA Fitzgerald, MA Kelliher Journal of Biological Chemistry 280 (44), 36560-36566, 2005 | 481 | 2005 |
BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment GE Winter, A Mayer, DL Buckley, MA Erb, JE Roderick, S Vittori, JM Reyes, ... Molecular cell 67 (1), 5-18. e19, 2017 | 391 | 2017 |
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia B Knoechel, JE Roderick, KE Williamson, J Zhu, JG Lohr, MJ Cotton, ... Nature genetics 46 (4), 364-370, 2014 | 383 | 2014 |
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia T Sanda, LN Lawton, MI Barrasa, ZP Fan, H Kohlhammer, A Gutierrez, ... Cancer cell 22 (2), 209-221, 2012 | 344 | 2012 |
Tal‐1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. MA Kelliher, DC Seldin, P Leder The EMBO journal 15 (19), 5160-5166, 1996 | 338 | 1996 |
NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis AK Pandey, Y Yang, Z Jiang, SM Fortune, F Coulombe, MA Behr, ... PLoS pathogens 5 (7), e1000500, 2009 | 336 | 2009 |
Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc VM Sharma, JA Calvo, KM Draheim, LA Cunningham, N Hermance, ... Molecular and cellular biology 26 (21), 8022-8031, 2006 | 334 | 2006 |
The public repository of xenografts enables discovery and randomized phase II-like trials in mice EC Townsend, MA Murakami, A Christodoulou, AL Christie, J Köster, ... Cancer cell 29 (4), 574-586, 2016 | 328 | 2016 |
Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo A Polykratis, N Hermance, M Zelic, J Roderick, C Kim, TM Van, TH Lee, ... The Journal of Immunology 193 (4), 1539-1543, 2014 | 318 | 2014 |
The kinase activity of Rip1 is not required for tumor necrosis factor-α-induced IκB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 TH Lee, J Shank, N Cusson, MA Kelliher Journal of Biological Chemistry 279 (32), 33185-33191, 2004 | 318 | 2004 |
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death D Weng, R Marty-Roix, S Ganesan, MK Proulx, GI Vladimer, WJ Kaiser, ... Proceedings of the National Academy of Sciences 111 (20), 7391-7396, 2014 | 314 | 2014 |