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Jeremy D Wilbur
Jeremy D Wilbur
Relay Therapeutics
Bestätigte E-Mail-Adresse bei relaytx.com
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Katanin contributes to interspecies spindle length scaling in Xenopus
R Loughlin, JD Wilbur, FJ McNally, FJ Nédélec, R Heald
Cell 147 (6), 1397-1407, 2011
2162011
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
J Hewett, P Ziefer, D Bergeron, T Naismith, H Boston, D Slater, J Wilbur, ...
Journal of neuroscience research 72 (2), 158-168, 2003
1422003
Mitotic spindle scaling during Xenopus development by kif2a and importin α
JD Wilbur, R Heald
Elife 2, e00290, 2013
1312013
Clathrin phosphorylation is required for actin recruitment at sites of bacterial adhesion and internalization
M Bonazzi, L Vasudevan, A Mallet, M Sachse, A Sartori, MC Prevost, ...
Journal of Cell Biology 195 (3), 525-536, 2011
1262011
The early onset dystonia protein torsinA interacts with kinesin light chain 1
C Kamm, H Boston, J Hewett, J Wilbur, DP Corey, PI Hanson, V Ramesh, ...
Journal of Biological Chemistry 279 (19), 19882-19892, 2004
1252004
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain
JD Wilbur, CY Chen, V Manalo, PK Hwang, RJ Fletterick, FM Brodsky
Journal of Biological Chemistry 283 (47), 32870-32879, 2008
1112008
A comparative analysis of spindle morphometrics across metazoans
ME Crowder, M Strzelecka, JD Wilbur, MC Good, G Von Dassow, R Heald
Current Biology 25 (11), 1542-1550, 2015
1002015
Interplay between spindle architecture and function
KJ Helmke, R Heald, JD Wilbur
International review of cell and molecular biology 306, 83-125, 2013
932013
Conformation switching of clathrin light chain regulates clathrin lattice assembly
JD Wilbur, PK Hwang, JA Ybe, M Lane, BD Sellers, MP Jacobson, ...
Developmental cell 18 (5), 854-861, 2010
882010
Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution
DE Wakeham, L Abi-Rached, MC Towler, JD Wilbur, P Parham, ...
Proceedings of the National Academy of Sciences 102 (20), 7209-7214, 2005
802005
Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors
DC Bragg, SM Camp, CA Kaufman, JD Wilbur, H Boston, DE Schuback, ...
Neuroscience 125 (3), 651-661, 2004
612004
New faces of the familiar clathrin lattice
JD Wilbur, PK Hwang, FM Brodsky
traffic 6 (4), 346-350, 2005
472005
N-terminal phosphorylation of p60 katanin directly regulates microtubule severing
E Whitehead, R Heald, JD Wilbur
Journal of molecular biology 425 (2), 214-221, 2013
452013
Mutations that alter RcdA surface residues decouple protein localization and CtrA proteolysis in Caulobacter crescentus
JA Taylor, JD Wilbur, SC Smith, KR Ryan
Journal of molecular biology 394 (1), 46-60, 2009
292009
Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain
JD Wilbur, PK Hwang, FM Brodsky, RJ Fletterick
Acta Crystallographica Section D: Biological Crystallography 66 (3), 314-318, 2010
82010
Identification of GDC-1971 (RLY-1971), a SHP2 inhibitor designed for the treatment of solid tumors
AM Taylor, BR Williams, F Giordanetto, EH Kelley, A Lescarbeau, ...
Journal of Medicinal Chemistry 66 (19), 13384-13399, 2023
62023
Discovery and characterization of RLY-2608: The first allosteric, mutant, and isoform-selective inhibitor of PI3Kα
E Pazolli, R Kipp, GH BA, A Iskandar, M Zubrowski
Mol Cancer Ther 20 (12 Suppl), P251, 2021
62021
Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors
B Williams, A Taylor, O Orozco, C Owen, E Kelley, A Lescarbeau, ...
Cancer Research 82 (12_Supplement), 3327-3327, 2022
52022
Cryptic no longer: Arrays of CLASP1 TOG domains
JD Wilbur, R Heald
Structure 21 (6), 869-870, 2013
52013
Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Kα inhibitor that decouples antitumor activity from hyperinsulinemia
A Varkaris, E Pazolli, H Gunaydin, Q Wang, L Pierce, AA Boezio, A Bulku, ...
Cancer Discovery 14 (2), 240-257, 2024
42024
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