| Functional genomics reveal that the serine synthesis pathway is essential in breast cancer R Possemato, KM Marks, YD Shaul, ME Pacold, D Kim, K Birsoy, ... Nature 476 (7360), 346-350, 2011 | 1635 | 2011 |
| Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation L Jackson-Grusby, C Beard, R Possemato, M Tudor, D Fambrough, ... Nature genetics 27 (1), 31-39, 2001 | 826 | 2001 |
| Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides K Birsoy, R Possemato, FK Lorbeer, EC Bayraktar, P Thiru, B Yucel, ... Nature 508 (7494), 108-112, 2014 | 742 | 2014 |
| NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis SW Alvarez, VO Sviderskiy, EM Terzi, T Papagiannakopoulos, AL Moreira, ... Nature 551 (7682), 639-643, 2017 | 544 | 2017 |
| The telomerase reverse transcriptase regulates chromatin state and DNA damage responses K Masutomi, R Possemato, JMY Wong, JL Currier, Z Tothova, JB Manola, ... Proceedings of the national academy of sciences 102 (23), 8222-8227, 2005 | 492 | 2005 |
| A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity BC Grabiner, V Nardi, K Birsoy, R Possemato, K Shen, S Sinha, A Jordan, ... Cancer discovery 4 (5), 554-563, 2014 | 479* | 2014 |
| An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA Y Maida, M Yasukawa, M Furuuchi, T Lassmann, R Possemato, ... Nature 461 (7261), 230-235, 2009 | 475 | 2009 |
| A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ... Nature chemical biology 12 (6), 452-458, 2016 | 464 | 2016 |
| Identification of specific PP2A complexes involved in human cell transformation W Chen, R Possemato, KT Campbell, CA Plattner, DC Pallas, WC Hahn Cancer cell 5 (2), 127-136, 2004 | 440 | 2004 |
| T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells G Lugo-Villarino, R Maldonado-López, R Possemato, C Peñaranda, ... Proceedings of the National Academy of Sciences 100 (13), 7749-7754, 2003 | 383 | 2003 |
| Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours J Garcia-Bermudez, L Baudrier, K La, XG Zhu, J Fidelin, VO Sviderskiy, ... Nature cell biology 20 (7), 775-781, 2018 | 357 | 2018 |
| SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance D Kim, BP Fiske, K Birsoy, E Freinkman, K Kami, RL Possemato, ... Nature 520 (7547), 363-367, 2015 | 357 | 2015 |
| MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors K Birsoy, T Wang, R Possemato, OH Yilmaz, CE Koch, WW Chen, ... Nature genetics 45 (1), 104-108, 2013 | 270 | 2013 |
| Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming M Vaeth, M Maus, S Klein-Hessling, E Freinkman, J Yang, M Eckstein, ... Immunity 47 (4), 664-679. e6, 2017 | 222 | 2017 |
| Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition YD Shaul, E Freinkman, WC Comb, JR Cantor, WL Tam, P Thiru, D Kim, ... Cell 158 (5), 1094-1109, 2014 | 222 | 2014 |
| Cancer-Associated PP2A A W Chen, JD Arroyo, JC Timmons Cancer Res 65, 8183-8192, 2005 | 216 | 2005 |
| Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer VI Sayin, SE LeBoeuf, SX Singh, SM Davidson, D Biancur, BS Guzelhan, ... Elife 6, e28083, 2017 | 190 | 2017 |
| Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs DR Minton, M Nam, DJ McLaughlin, J Shin, EC Bayraktar, SW Alvarez, ... Molecular cell 69 (4), 610-621. e5, 2018 | 152 | 2018 |
| KRAS4A directly regulates hexokinase 1 CR Amendola, JP Mahaffey, SJ Parker, IM Ahearn, WC Chen, M Zhou, ... Nature 576 (7787), 482-486, 2019 | 143 | 2019 |
| Amino acid management in cancer ZY Tsun, R Possemato Seminars in cell & developmental biology 43, 22-32, 2015 | 120 | 2015 |
David M. SabatiniInstitute of Organic Chemistry and Biochemistry of the CASVerified email at uochb.cas.cz
