Jean-Philippe Julien
Jean-Philippe Julien
Scientist, Hospital for Sick Children Research Institute
Verified email at sickkids.ca - Homepage
Title
Cited by
Cited by
Year
Broad neutralization coverage of HIV by multiple highly potent antibodies
LM Walker, M Huber, KJ Doores, E Falkowska, R Pejchal, JP Julien, ...
Nature 477 (7365), 466-470, 2011
13602011
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
JS McLellan, M Pancera, C Carrico, J Gorman, JP Julien, R Khayat, ...
Nature 480 (7377), 336-343, 2011
8382011
Crystal structure of a soluble cleaved HIV-1 envelope trimer
JP Julien, A Cupo, D Sok, RL Stanfield, D Lyumkis, MC Deller, PJ Klasse, ...
Science 342 (6165), 1477-1483, 2013
7772013
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield
R Pejchal, KJ Doores, LM Walker, R Khayat, PS Huang, SK Wang, ...
Science 334 (6059), 1097-1103, 2011
7152011
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer
D Lyumkis, JP Julien, N de Val, A Cupo, CS Potter, PJ Klasse, DR Burton, ...
Science 342 (6165), 1484-1490, 2013
6372013
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
RW Sanders, R Derking, A Cupo, JP Julien, A Yasmeen, N de Val, HJ Kim, ...
PLoS pathog 9 (9), e1003618, 2013
6102013
Rational HIV immunogen design to target specific germline B cell receptors
J Jardine, JP Julien, S Menis, T Ota, O Kalyuzhniy, A McGuire, D Sok, ...
Science 340 (6133), 711-716, 2013
5192013
HIV-1 neutralizing antibodies induced by native-like envelope trimers
RW Sanders, MJ van Gils, R Derking, D Sok, TJ Ketas, JA Burger, ...
Science 349 (6244), 2015
3732015
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120
L Kong, JH Lee, KJ Doores, CD Murin, JP Julien, R McBride, Y Liu, ...
Nature Structural and Molecular Biology 20 (7), 796, 2013
3332013
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
JP Julien, D Sok, R Khayat, JH Lee, KJ Doores, LM Walker, A Ramos, ...
PLoS Pathog 9 (5), e1003342, 2013
3232013
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
C Blattner, JH Lee, K Sliepen, R Derking, E Falkowska, AT de la Peņa, ...
Immunity 40 (5), 669-680, 2014
3052014
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
JP Julien, JH Lee, A Cupo, CD Murin, R Derking, S Hoffenberg, ...
Proceedings of the National Academy of Sciences 110 (11), 4351-4356, 2013
2672013
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
D Sok, MJ van Gils, M Pauthner, JP Julien, KL Saye-Francisco, J Hsueh, ...
Proceedings of the National Academy of Sciences 111 (49), 17624-17629, 2014
2342014
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
JG Jardine, DW Kulp, C Havenar-Daughton, A Sarkar, B Briney, D Sok, ...
Science 351 (6280), 1458-1463, 2016
2312016
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
SW de Taeye, G Ozorowski, AT de la Peņa, M Guttman, JP Julien, ...
Cell 163 (7), 1702-1715, 2015
2032015
A Native-Like SOSIP. 664 Trimer Based on an HIV-1 Subtype B env Gene
P Pugach, G Ozorowski, A Cupo, R Ringe, A Yasmeen, N de Val, ...
Journal of virology 89 (6), 3380-3395, 2015
1892015
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
D Sok, U Laserson, J Laserson, Y Liu, F Vigneault, JP Julien, B Briney, ...
PLoS pathog 9 (11), e1003754, 2013
1822013
Structural evolution of glycan recognition by a family of potent HIV antibodies
F Garces, D Sok, L Kong, R McBride, HJ Kim, KF Saye-Francisco, ...
Cell 159 (1), 69-79, 2014
1802014
Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV
D Sok, KJ Doores, B Briney, KM Le, KL Saye-Francisco, A Ramos, ...
Science translational medicine 6 (236), 236ra63-236ra63, 2014
1692014
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation
RP Ringe, RW Sanders, A Yasmeen, HJ Kim, JH Lee, A Cupo, J Korzun, ...
Proceedings of the National Academy of Sciences 110 (45), 18256-18261, 2013
1682013
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