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Alessandro Michelucci
Alessandro Michelucci
Luxembourg Institute of Health
Bestätigte E-Mail-Adresse bei lih.lu
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Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
A Michelucci, T Cordes, J Ghelfi, A Pailot, N Reiling, O Goldmann, T Binz, ...
Proceedings of the National Academy of Sciences 110 (19), 7820-7825, 2013
9822013
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-β
A Michelucci, T Heurtaux, L Grandbarbe, E Morga, P Heuschling
Journal of neuroimmunology 210 (1-2), 3-12, 2009
4862009
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
A Dirkse, A Golebiewska, T Buder, PV Nazarov, A Muller, S Poovathingal, ...
Nature communications 10 (1), 1787, 2019
4542019
Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels
T Cordes, M Wallace, A Michelucci, AS Divakaruni, SC Sapcariu, C Sousa, ...
Journal of Biological Chemistry 291 (27), 14274-14284, 2016
4252016
The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity
J Domínguez-Andrés, B Novakovic, Y Li, BP Scicluna, MS Gresnigt, ...
Cell metabolism 29 (1), 211-220. e5, 2019
2762019
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
C Sousa, A Golebiewska, SK Poovathingal, T Kaoma, Y Pires‐Afonso, ...
EMBO reports 19 (11), e46171, 2018
2362018
Itaconic acid: the surprising role of an industrial compound as a mammalian antimicrobial metabolite
T Cordes, A Michelucci, K Hiller
Annual review of nutrition 35, 451-473, 2015
1782015
Cellular and molecular characterization of microglia: a unique immune cell population
C Sousa, K Biber, A Michelucci
Frontiers in immunology 8, 245768, 2017
1762017
Notch signaling modulates the activation of microglial cells
L Grandbarbe, A Michelucci, T Heurtaux, K Hemmer, E Morga, ...
Glia 55 (15), 1519-1530, 2007
1212007
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
A Golebiewska, AC Hau, A Oudin, D Stieber, YA Yabo, V Baus, ...
Acta Neuropathologica 140, 919-949, 2020
852020
Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in …
A Tallam, TM Perumal, PM Antony, C Jäger, JV Fritz, L Vallar, R Balling, ...
PLoS One 11 (2), e0149050, 2016
812016
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation
M Faas, N Ipseiz, J Ackermann, S Culemann, A Grüneboom, F Schröder, ...
Immunity 54 (11), 2531-2546. e5, 2021
762021
Inflammation promotes a conversion of astrocytes into neural progenitor cells via NF-κB activation
S Gabel, E Koncina, G Dorban, T Heurtaux, C Birck, E Glaab, ...
Molecular neurobiology 53, 5041-5055, 2016
722016
Microglial activation depends on beta‐amyloid conformation: role of the formylpeptide receptor 2
T Heurtaux, A Michelucci, S Losciuto, C Gallotti, P Felten, G Dorban, ...
Journal of neurochemistry 114 (2), 576-586, 2010
722010
Jagged1 regulates the activation of astrocytes via modulation of NFκB and JAK/STAT/SOCS pathways
E Morga, L Mouad‐Amazzal, P Felten, T Heurtaux, M Moro, A Michelucci, ...
Glia 57 (16), 1741-1753, 2009
602009
Revealing and harnessing tumour-associated microglia/macrophage heterogeneity in glioblastoma
Y Pires-Afonso, SP Niclou, A Michelucci
International journal of molecular sciences 21 (3), 689, 2020
582020
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
J Meiser, S Delcambre, A Wegner, C Jäger, J Ghelfi, AF d'Herouel, ...
Neurobiology of disease 89, 112-125, 2016
562016
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
F Chen, WAM Elgaher, M Winterhoff, K Büssow, FH Waqas, E Graner, ...
Nature Metabolism 4 (5), 534-546, 2022
522022
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
A Sohail, AA Iqbal, N Sahini, F Chen, M Tantawy, SFH Waqas, ...
PLoS pathogens 18 (1), e1010219, 2022
472022
The neurogenic potential of astrocytes is regulated by inflammatory signals
A Michelucci, A Bithell, MJ Burney, CE Johnston, KY Wong, SW Teng, ...
Molecular neurobiology 53, 3724-3739, 2016
442016
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