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Francis Blokzijl
Francis Blokzijl
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Jahr
A living biobank of breast cancer organoids captures disease heterogeneity
N Sachs, J De Ligt, O Kopper, E Gogola, G Bounova, F Weeber, ...
Cell 172 (1), 373-386. e10, 2018
14462018
Long-term culture of genome-stable bipotent stem cells from adult human liver
M Huch, H Gehart, R Van Boxtel, K Hamer, F Blokzijl, MMA Verstegen, ...
Cell 160 (1), 299-312, 2015
14332015
Tissue-specific mutation accumulation in human adult stem cells during life
F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ...
Nature 538 (7624), 260-264, 2016
8762016
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
F Blokzijl, R Janssen, R Van Boxtel, E Cuppen
Genome medicine 10, 1-11, 2018
5542018
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer
J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ...
Science 358 (6360), 234-238, 2017
4102017
Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia
E Waanders, Z Gu, SM Dobson, Ž Antić, JC Crawford, X Ma, ...
Blood cancer discovery 1 (1), 96-111, 2020
1172020
Genomic landscape of rat strain and substrain variation
R Hermsen, J de Ligt, W Spee, F Blokzijl, S Schäfer, E Adami, S Boymans, ...
BMC genomics 16, 1-14, 2015
922015
Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer
M Jager, F Blokzijl, E Kuijk, J Bertl, M Vougioukalaki, R Janssen, ...
Genome research 29 (7), 1067-1077, 2019
792019
Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure
EW Kuijk, S Rasmussen, F Blokzijl, M Huch, H Gehart, P Toonen, ...
Scientific reports 6 (1), 22154, 2016
612016
Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures
M Jager, F Blokzijl, V Sasselli, S Boymans, R Janssen, N Besselink, ...
Nature protocols 13 (1), 59-78, 2018
582018
Mutational processes in hepatocellular carcinoma: the story of aristolochic acid
JC Nault, E Letouzé
Seminars in liver disease 39 (03), 334-340, 2019
292019
Early divergence of mutational processes in human fetal tissues
E Kuijk, F Blokzijl, M Jager, N Besselink, S Boymans, ...
Science advances 5 (5), eaaw1271, 2019
292019
Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney
F Schutgens, MB Rookmaaker, F Blokzijl, R van Boxtel, R Vries, ...
Proceedings of the National Academy of Sciences 114 (52), E11190-E11198, 2017
262017
Chuva de Sousa Lopes SM
EW Kuijk, F Blokzijl, M Jager, N Besselink, S Boymans
Early divergence of mutational processes in human fetal tissues. Sci Adv 5 (5), 2019
92019
Deficiency of global genome nucleotide excision repair explains mutational signature observed in cancer
M Jager, F Blokzijl, E Kuijk, M Vougioukalaki, R Janssen, N Besselink, ...
bioRxiv, 221168, 2017
12017
VIBE: An R-package for advanced RNA-seq data exploration, disease stratification and therapeutic targeting
I Khatri, SD Asten, LF Moreno, BW Higgs, C Klijn, F Blokzijl, ICRM Kolder
bioRxiv, 2023.10. 04.560641, 2023
2023
Decoding the mutational history of human stem cells: From patterns to mechanisms
F Blokzijl
Utrecht University, 2018
2018
Introduction to MutationalPatterns
F Blokzijl, R Janssen, R Van Boxtel, E Cuppen
2018
Higher mutation accumulation rate in human stem cells during fetal development than postnatal life
F Blokzijl, E Kuijk, M Jager, SMC de Sousa Lopes, R van Boxtel, ...
Decoding the mutational history of human stem cells, 117, 2018
2018
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