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Lisa M. Tuttle
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Divergent evolution of protein conformational dynamics in dihydrofolate reductase
G Bhabha, DC Ekiert, M Jennewein, CM Zmasek, LM Tuttle, G Kroon, ...
Nat Struct Mol Biol, 2013
1692013
Gcn4-mediator specificity is mediated by a large and dynamic fuzzy protein-protein complex
LM Tuttle, D Pacheco, L Warfield, J Luo, J Ranish, S Hahn, RE Klevit
Cell reports 22 (12), 3251-3264, 2018
1182018
A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface
L Warfield, LM Tuttle, D Pacheco, RE Klevit, S Hahn
Proceedings of the National Academy of Sciences 111 (34), E3506-E3513, 2014
952014
Model-driven designs of an oscillating gene network
LM Tuttle, H Salis, J Tomshine, YN Kaznessis
Biophysical journal 89 (6), 3873-3883, 2005
67*2005
BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1
SR Witus, AL Burrell, DP Farrell, J Kang, M Wang, JM Hansen, A Pravat, ...
Nature structural & molecular biology 28 (3), 268-277, 2021
592021
Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4
LM Tuttle, D Pacheco, L Warfield, DB Wilburn, S Hahn, RE Klevit
Nature communications 12 (1), 2220, 2021
362021
Side-Chain Conformational Heterogeneity of Intermediates in the Escherichia coli Dihydrofolate Reductase Catalytic Cycle
LM Tuttle, HJ Dyson, PE Wright
Biochemistry, 2013
202013
Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR
G Bhabha, L Tuttle, MA Martinez-Yamout, PE Wright
FEBS letters 585 (22), 3528-3532, 2011
162011
Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution
DB Wilburn, LM Tuttle, RE Klevit, WJ Swanson
Proceedings of the National Academy of Sciences 115 (6), 1310-1315, 2018
142018
Side Chain Conformational Averaging in Human Dihydrofolate Reductase
LM Tuttle, HJ Dyson, PE Wright
Biochemistry, 2014
112014
Indirect sexual selection drives rapid sperm protein evolution in abalone
DB Wilburn, LM Tuttle, RE Klevit, WJ Swanson
Elife 8, e52628, 2019
82019
Gcn4-Mediator specificity is mediated by a large and dynamic fuzzy protein-protein complex. Cell Rep 22: 3251–3264
LM Tuttle, D Pacheco, L Warfield, J Luo, J Ranish, S Hahn, RE Klevit
62018
BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
SR Witus, LM Tuttle, W Li, A Zelter, M Wang, KE Kermoade, DB Wilburn, ...
The EMBO Journal 42 (15), e113565, 2023
32023
INDIRECT SEXUAL SELECTION DRIVES RAPID EVOLUTION OF AN INTRINSICALLY DISORDERED SPERM PROTEIN
D Wilburn, L Tuttle, R Klevit, W Swanson
PROTEIN SCIENCE 28, 72-73, 2019
2019
Indirect Sexual Selection Drives Rapid Sperm Protein Evolution
DB Wilburn, LM Tuttle, RE Klevit, WJ Swanson
bioRxiv, 682062, 2019
2019
NMR studies of side chain conformations and dynamics in Escherichia coli and human DHFR
LM Tuttle
The Scripps Research Institute, 2012
2012
Masters Thesis: Model-driven designs of an oscillating gene network
LM Tuttle
University of Minnesota, Twin Cities, 2005
2005
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