Thomas M Tomasiak
Thomas M Tomasiak
Assistant Professor of Chemistry and Biochemistry, University of Arizona
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Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer
BC Monk, TM Tomasiak, MV Keniya, FU Huschmann, JDA Tyndall, ...
Proceedings of the National Academy of Sciences 111 (10), 3865-3870, 2014
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter
JM Kim, S Wu, TM Tomasiak, C Mergel, MB Winter, SB Stiller, ...
Nature 517 (7534), 396-400, 2015
A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors
TM Pyburn, BA Bensing, YQ Xiong, BJ Melancon, TM Tomasiak, NJ Ward, ...
PLoS pathogens 7 (7), e1002112, 2011
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP
A Nöll, C Thomas, V Herbring, T Zollmann, K Barth, AR Mehdipour, ...
Proceedings of the National Academy of Sciences 114 (4), E438-E447, 2017
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells
JG Quirit, SN Lavrenov, K Poindexter, J Xu, C Kyauk, KA Durkin, ...
Biochemical pharmacology 127, 13-27, 2017
A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II
TM Tomasiak, E Maklashina, G Cecchini, TM Iverson
Journal of biological chemistry 283 (22), 15460-15468, 2008
Geometric restraint drives on-and off-pathway catalysis by the Escherichia coli menaquinol: fumarate reductase
TM Tomasiak, TL Archuleta, J Andréll, C Luna-Chávez, TA Davis, ...
Journal of biological chemistry 286 (4), 3047-3056, 2011
The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
NK Khandelwal, CR Millan, SI Zangari, S Avila, D Williams, TM Thaker, ...
Nature Communications 13 (1), 1278, 2022
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter
TM Thaker, S Mishra, W Zhou, M Mohan, Q Tang, JD Faraldo-Goméz, ...
Nature chemical biology 18 (2), 226-235, 2022
General qPCR and plate reader methods for rapid optimization of membrane protein purification and crystallization using thermostability assays
TM Tomasiak, BP Pedersen, S Chaudhary, A Rodriguez, YR Colmanares, ...
Current Protocols in Protein Science 77 (1), 29.11. 1-29.11. 14, 2014
Plasticity of the quinone-binding site of the complex II homolog quinol: fumarate reductase
PK Singh, M Sarwar, E Maklashina, V Kotlyar, S Rajagukguk, ...
Journal of Biological Chemistry 288 (34), 24293-24301, 2013
Succinate as donor; fumarate as acceptor
TM Tomasiak, G Cecchini, TM Iverson
EcoSal Plus 2 (2), 10.1128/ecosal. 3.2. 6, 2007
Vaccines to prevent coccidioidomycosis: a gene-deletion mutant of Coccidioides posadasii as a viable candidate for human trials
JN Galgiani, LF Shubitz, MJ Orbach, MA Mandel, DA Powell, BS Klein, ...
Journal of Fungi 8 (8), 838, 2022
New crystal forms of the integral membrane Escherichia coli quinol: fumarate reductase suggest that ligands control domain movement
CA Starbird, TM Tomasiak, PK Singh, V Yankovskaya, E Maklashina, ...
Journal of structural biology 202 (1), 100-104, 2018
’Connell JD, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the …
BC Monk, TM Tomasiak, MV Keniya, FU Huschmann, O Tyndall JDa
Proc Natl Acad Sci US A 111, 3865-70, 2014
Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids
Y Zhang, ZY Hu, XC Li, XX Guo
Synthesis 51 (08), 1803-1808, 2019
A conserved motif in intracellular loop 1 stabilizes the outward-facing conformation of TmrAB
CR Millan, M Francis, NK Khandelwal, VF Thompson, TM Thaker, ...
Journal of molecular biology 433 (16), 166834, 2021
Subnanometer resolution cryo-EM structure of a nucleotide free heterodimeric ABC exporter
JM Kim, S Wu, T Tomasiak, C Mergel, MB Winter, SB Stiller, ...
Nature 517 (7534), 396, 2015
Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1
NK Khandelwal, TM Tomasiak
Nature Communications 15 (1), 2389, 2024
Cryo-EM structure of an elusive pre-transport intermediate of the multidrug ABC transporter BmrCD reveals modes of asymmetric drug binding
TM Thaker, S Mishra, W Zhou, JD Faraldo-Gomez, HS Mchaourab, ...
bioRxiv, 2021.03. 13.435271, 2021
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