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Outi Haapanen
Outi Haapanen
Post Doctoral Researcher, University of Helsinki
Verified email at helsinki.fi
Title
Cited by
Cited by
Year
High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease
K Parey, O Haapanen, V Sharma, H Köfeler, T Züllig, S Prinz, K Siegmund, ...
Science Advances 5 (12), eaax9484, 2019
1302019
Redox-coupled quinone dynamics in the respiratory complex I
J Warnau, V Sharma, AP Gamiz-Hernandez, A Di Luca, O Haapanen, ...
Proceedings of the National Academy of Sciences 115 (36), E8413-E8420, 2018
912018
High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism
K Parey, J Lasham, DJ Mills, A Djurabekova, O Haapanen, EG Yoga, ...
Science advances 7 (46), eabj3221, 2021
672021
Role of water and protein dynamics in proton pumping by respiratory complex I
O Haapanen, V Sharma
Scientific reports 7 (1), 1-12, 2017
592017
Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex
A Mühleip, RK Flygaard, R Baradaran, O Haapanen, T Gruhl, ...
Nature, 1-5, 2023
502023
Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I
O Haapanen, A Djurabekova, V Sharma
Frontiers in chemistry 7, 221, 2019
462019
Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics
EG Yoga, O Haapanen, I Wittig, K Siegmund, V Sharma, V Zickermann
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1860 (7), 573-581, 2019
362019
A modeling and simulation perspective on the mechanism and function of respiratory complex I
O Haapanen, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1859 (7), 510-523, 2018
362018
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
E Galemou Yoga, K Parey, A Djurabekova, O Haapanen, K Siegmund, ...
Nature communications 11 (1), 1-8, 2020
332020
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I
S Uno, T Masuya, K Shinzawa-Itoh, J Lasham, O Haapanen, T Shiba, ...
Journal of Biological Chemistry 295 (8), 2449-2463, 2020
232020
Coupling of quinone dynamics to proton pumping in respiratory complex I
O Haapanen, M Reidelbach, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1861 (12), 148287, 2020
202020
Redox-and protonation-state driven substrate-protein dynamics in respiratory complex I
O Haapanen, V Sharma
Current opinion in electrochemistry 29, 100741, 2021
172021
Proton motive function of the terminal antiporter-like subunit in respiratory complex I
A Djurabekova, O Haapanen, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1861 (7), 148185, 2020
132020
Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations
Y Lee, O Haapanen, A Altmeyer, W Kühlbrandt, V Sharma, V Zickermann
Nature Communications 13 (1), 6091, 2022
102022
Atomistic Molecular Dynamics Simulations of Mitochondrial DNA Polymerase γ: Novel Mechanisms of Function and Pathogenesis
L Euro, O Haapanen, T Róg, I Vattulainen, A Suomalainen, V Sharma
Biochemistry 56 (9), 1227-1238, 2017
72017
Tunnel dynamics of quinone derivatives and its coupling to protein conformational rearrangements in respiratory complex I
J Lasham, O Haapanen, V Zickermann, V Sharma
Biochimica et Biophysica Acta (BBA)-Bioenergetics, 148951, 2022
52022
Docking and molecular simulations reveal a quinone‐binding site on the surface of respiratory complex I
A Djurabekova, E Galemou Yoga, A Nyman, A Pirttikoski, V Zickermann, ...
FEBS letters 596 (9), 1133-1146, 2022
52022
Targeting respiratory complex I—molecular mechanism and drug design
V Sharma, J Lasham, O Haapanen
Clinical Bioenergetics, 327-340, 2021
12021
Proton translocation channels in respiratory complex I probed by molecular dynamics simulations
O Haapanen
12017
Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A
Y Liu, ODC Ribeiro, O Haapanen, GB Craven, V Sharma, SP Muench, ...
Journal of Biological Chemistry 298 (10), 2022
2022
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