Michael Harbut
Michael Harbut
Janssen Research & Development
Verified email at its.jnj.com
Title
Cited by
Cited by
Year
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells
R Chandramohanadas, PH Davis, DP Beiting, MB Harbut, C Darling, ...
science 324 (5928), 794-797, 2009
1622009
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
MB Harbut, C Vilchèze, X Luo, ME Hensler, H Guo, B Yang, AK Chatterjee, ...
Proceedings of the National Academy of Sciences 112 (14), 4453-4458, 2015
1512015
Role for DNA polymerase κ in the processing of N2-N2-guanine interstrand cross-links
IG Minko, MB Harbut, ID Kozekov, A Kozekova, PM Jakobs, SB Olson, ...
Journal of Biological Chemistry 283 (25), 17075-17082, 2008
1402008
Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases
MB Harbut, G Velmourougane, S Dalal, G Reiss, JC Whisstock, O Onder, ...
Proceedings of the National Academy of Sciences 108 (34), E526-E534, 2011
1002011
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
MB Harbut, BA Patel, BKS Yeung, CW McNamara, AT Bright, J Ballard, ...
Proceedings of the National Academy of Sciences 109 (52), 21486-21491, 2012
812012
Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV
A Kumari, IG Minko, MB Harbut, SE Finkel, MF Goodman, RS Lloyd
Journal of Biological Chemistry 283 (41), 27433-27437, 2008
632008
Synthesis of new (−)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase
G Velmourougane, MB Harbut, S Dalal, S McGowan, CA Oellig, ...
Journal of medicinal chemistry 54 (6), 1655-1666, 2011
602011
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB
JP Mallari, AA Shelat, T Obrien, CR Caffrey, A Kosinski, M Connelly, ...
Journal of medicinal chemistry 51 (3), 545-552, 2008
602008
Development of bestatin-based activity-based probes for metallo-aminopeptidases
MB Harbut, G Velmourougane, G Reiss, R Chandramohanadas, ...
Bioorganic & medicinal chemistry letters 18 (22), 5932-5936, 2008
342008
Replication Bypass of N2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerases η and ι
AR Klug, MB Harbut, RS Lloyd, IG Minko
Chemical research in toxicology 25 (3), 755-762, 2012
282012
Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase exhibit antimycobacterial activity
MB Harbut, B Yang, R Liu, T Yano, C Vilchèze, B Cheng, J Lockner, ...
Angewandte Chemie 130 (13), 3536-3540, 2018
192018
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
F Mietton, EF Ferri, M Champleboux, N Zala, D Maubon, Y Zhou, ...
Nature Communications 8 (15482), 2017
132017
Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes
R Liu, X Lyu, SM Batt, MH Hsu, MB Harbut, C Vilchèze, B Cheng, K Ajayi, ...
Angewandte Chemie International Edition 56 (42), 13011-13015, 2017
112017
Modulation of the turnover of formamidopyrimidine DNA glycosylase
MB Harbut, M Meador, ML Dodson, RS Lloyd
Biochemistry 45 (23), 7341-7346, 2006
12006
Chemical Genetic Approaches for Elucidating Protease Function and Drug-Target Potential in Plasmodium Falciparum
M Harbut
2012
Bypass of N2-Deoxyguanosine Interstrand Cross-Links by Human DNA Polymerase Eta.: P18
G Minko, R Klug, B Harbut, S Lloyd
Environmental & Molecular Mutagenesis 51 (7), 2010
2010
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