| Large shifts in pKa values of lysine residues buried inside a protein DG Isom, CA Castañeda, BR Cannon, B García-Moreno E Proceedings of the National Academy of Sciences 108 (13), 5260-5265, 2011 | 488 | 2011 |
| Charges in the hydrophobic interior of proteins DG Isom, CA Castañeda, BR Cannon, PD Velu, B García-Moreno E Proceedings of the National Academy of Sciences 107 (37), 16096-16100, 2010 | 256 | 2010 |
| High tolerance for ionizable residues in the hydrophobic interior of proteins DG Isom, BR Cannon, CA Castañeda, A Robinson, B García-Moreno E Proceedings of the National Academy of Sciences 105 (46), 17784-17788, 2008 | 165 | 2008 |
| The pKa values of acidic and basic residues buried at the same internal location in a protein are governed by different factors MJ Harms, CA Castañeda, JL Schlessman, GR Sue, DG Isom, ... Journal of molecular biology 389 (1), 34-47, 2009 | 155 | 2009 |
| Local secondary structure content predicts folding rates for simple, two-state proteins H Gong, DG Isom, R Srinivasan, GD Rose Journal of molecular biology 327 (5), 1149-1154, 2003 | 144 | 2003 |
| One year of SARS-CoV-2: How much has the virus changed? S Vilar, DG Isom Biology 10 (2), 91, 2021 | 126 | 2021 |
| Protons as second messenger regulators of G protein signaling DG Isom, V Sridharan, R Baker, ST Clement, DM Smalley, HG Dohlman Molecular cell 51 (4), 531-538, 2013 | 80 | 2013 |
| Mutations in ATP1A1 cause dominant Charcot-Marie-Tooth type 2 P Lassuthova, AP Rebelo, G Ravenscroft, PJ Lamont, MR Davis, ... The American Journal of Human Genetics 102 (3), 505-514, 2018 | 77 | 2018 |
| Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination R Baker, EM Wilkerson, K Sumita, DG Isom, AT Sasaki, HG Dohlman, ... Journal of Biological Chemistry 288 (52), 36856-36862, 2013 | 74 | 2013 |
| Hydration of the folding transition state ensemble of a protein L Brun, DG Isom, P Velu, B García-Moreno, CA Royer Biochemistry 45 (11), 3473-3480, 2006 | 58 | 2006 |
| DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery NJ Kapolka, GJ Taghon, JB Rowe, WM Morgan, JF Enten, NA Lambert, ... Proceedings of the National Academy of Sciences 117 (23), 13117-13126, 2020 | 51 | 2020 |
| Predictable cholesterol binding sites in GPCRs lack consensus motifs GJ Taghon, JB Rowe, NJ Kapolka, DG Isom Structure 29 (5), 499-506. e3, 2021 | 46 | 2021 |
| Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation DG Isom, HG Dohlman Proceedings of the National Academy of Sciences 112 (18), 5702-5707, 2015 | 44 | 2015 |
| The evolution and mechanism of GPCR proton sensing JB Rowe, NJ Kapolka, GJ Taghon, WM Morgan, DG Isom Journal of Biological Chemistry 296, 2021 | 40 | 2021 |
| V i-value analysis: a pressure-based method for mapping the folding transition state ensemble of proteins L Mitra, K Hata, R Kono, A Maeno, D Isom, JB Rouget, R Winter, ... Journal of the American Chemical Society 129 (46), 14108-14109, 2007 | 39 | 2007 |
| Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity DG Isom, E Vardy, TG Oas, HW Hellinga Proceedings of the National Academy of Sciences 107 (11), 4908-4913, 2010 | 36 | 2010 |
| A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity DG Isom, PR Marguet, TG Oas, HW Hellinga Proteins: Structure, Function, and Bioinformatics 79 (4), 1034-1047, 2011 | 35 | 2011 |
| Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast DG Isom, SC Page, LB Collins, NJ Kapolka, GJ Taghon, HG Dohlman Journal of Biological Chemistry 293 (7), 2318-2329, 2018 | 30 | 2018 |
| Amino acid metabolites that regulate G protein signaling during osmotic stress JP Shellhammer, E Morin-Kensicki, JP Matson, G Yin, DG Isom, ... PLoS Genetics 13 (5), e1006829, 2017 | 21 | 2017 |
| HCAR3: an underexplored metabolite sensor NJ Kapolka, DG Isom Nature reviews. Drug discovery 19 (11), 745, 2020 | 20 | 2020 |
