| The consensus molecular subtypes of colorectal cancer J Guinney, R Dienstmann, X Wang, A De Reynies, A Schlicker, ... Nature medicine 21 (11), 1350-1356, 2015 | 3928 | 2015 |
| Wnt activity defines colon cancer stem cells and is regulated by the microenvironment L Vermeulen, F De Sousa E Melo, M Van Der Heijden, K Cameron, ... Nature cell biology 12 (5), 468-476, 2010 | 1978 | 2010 |
| Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity L Vermeulen, M Todaro, F de Sousa Mello, MR Sprick, K Kemper, ... Proceedings of the National Academy of Sciences 105 (36), 13427-13432, 2008 | 871 | 2008 |
| Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions F De Sousa E Melo, X Wang, M Jansen, E Fessler, A Trinh, ... Nature medicine 19 (5), 614-618, 2013 | 807 | 2013 |
| The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia TJ Schuijt, JM Lankelma, BP Scicluna, FS e Melo, JJTH Roelofs, ... Gut 65 (4), 575-583, 2016 | 613 | 2016 |
| Cancer Stem Cell Niche: The Place to BeThe Cancer Stem Cell Niche T Borovski, F De Sousa E Melo, L Vermeulen, JP Medema Cancer research 71 (3), 634-639, 2011 | 604 | 2011 |
| A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer F de Sousa e Melo, AV Kurtova, JM Harnoss, N Kljavin, JD Hoeck, J Hung, ... Nature 543 (7647), 676-680, 2017 | 521 | 2017 |
| The developing cancer stem-cell model: clinical challenges and opportunities L Vermeulen, FS e Melo, DJ Richel, JP Medema The lancet oncology 13 (2), e83-e89, 2012 | 444 | 2012 |
| Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients EM Felipe de Sousa, S Colak, J Buikhuisen, J Koster, K Cameron, ... Cell stem cell 9 (5), 476-485, 2011 | 335 | 2011 |
| Cancer heterogeneity—a multifaceted view FDSE Melo, L Vermeulen, E Fessler, JP Medema EMBO reports 14 (8), 686-695, 2013 | 280 | 2013 |
| Targeting Wnt signaling in colon cancer stem cells EMF de Sousa, L Vermeulen, D Richel, JP Medema Clinical Cancer Research 17 (4), 647-653, 2011 | 244 | 2011 |
| Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function EE Storm, S Durinck, F de Sousa E Melo, J Tremayne, N Kljavin, C Tan, ... Nature 529 (7584), 97-100, 2016 | 212 | 2016 |
| Wnt signaling in cancer stem cell biology F De Sousa e Melo, L Vermeulen Cancers 8 (7), 60, 2016 | 192 | 2016 |
| Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by ImmunohistochemistryColorectal Cancer Subtypes by Immunohistochemistry A Trinh, K Trumpi, F De Sousa E Melo, X Wang, JH De Jong, E Fessler, ... Clinical cancer research 23 (2), 387-398, 2017 | 150 | 2017 |
| Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer KJ Lenos, DM Miedema, SC Lodestijn, LE Nijman, T van den Bosch, ... Nature cell biology 20 (10), 1193-1202, 2018 | 141 | 2018 |
| Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame? E Fessler, FE Dijkgraaf, EM Felipe De Sousa, JP Medema Cancer letters 341 (1), 97-104, 2013 | 140 | 2013 |
| TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype E Fessler, J Drost, SR van Hooff, JF Linnekamp, X Wang, M Jansen, ... EMBO molecular medicine 8 (7), 745-760, 2016 | 137 | 2016 |
| OTULIN limits cell death and inflammation by deubiquitinating LUBAC K Heger, KE Wickliffe, A Ndoja, J Zhang, A Murthy, DL Dugger, ... Nature 559 (7712), 120-124, 2018 | 131 | 2018 |
| Cellular plasticity in intestinal homeostasis and disease FS e Melo, FJ de Sauvage Cell Stem Cell 24 (1), 54-64, 2019 | 107 | 2019 |
| Mutations in the Ras–Raf axis underlie the prognostic value of CD133 in colorectal cancer K Kemper, M Versloot, K Cameron, S Colak, F de Sousa e Melo, ... Clinical Cancer Research 18 (11), 3132-3141, 2012 | 94 | 2012 |
