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David G Brooks
David G Brooks
University of Toronto and Princess Margeret Cancer Center
Verified email at uhnresearch.ca
Title
Cited by
Cited by
Year
Interleukin-10 determines viral clearance or persistence in vivo
DG Brooks, MJ Trifilo, KH Edelmann, L Teyton, DB McGavern, ...
Nature medicine 12 (11), 1301-1309, 2006
11652006
Blockade of chronic type I interferon signaling to control persistent LCMV infection
EB Wilson, DH Yamada, H Elsaesser, J Herskovitz, J Deng, G Cheng, ...
Science 340 (6129), 202-207, 2013
8002013
IL-21 is required to control chronic viral infection
H Elsaesser, K Sauer, DG Brooks
Science 324 (5934), 1569-1572, 2009
6832009
Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Y Kidani, H Elsaesser, MB Hock, L Vergnes, KJ Williams, JP Argus, ...
Nature immunology 14 (5), 489-499, 2013
4712013
Type I interferon in chronic virus infection and cancer
LM Snell, TL McGaha, DG Brooks
Trends in immunology 38 (8), 542-557, 2017
3842017
Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling
AG York, KJ Williams, JP Argus, QD Zhou, G Brar, L Vergnes, EE Gray, ...
Cell 163 (7), 1716-1729, 2015
3822015
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells
LM Fahey, EB Wilson, H Elsaesser, CD Fistonich, DB McGavern, ...
Journal of Experimental Medicine 208 (5), 987-999, 2011
3752011
Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10
OL Rojas, AK Pröbstel, EA Porfilio, AA Wang, M Charabati, T Sun, ...
Cell 176 (3), 610-624. e18, 2019
3332019
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
DG Brooks, L Teyton, MBA Oldstone, DB McGavern
Journal of virology 79 (16), 10514-10527, 2005
3082005
Effects of prostratin on T-cell activation and human immunodeficiency virus latency
YD Korin, DG Brooks, S Brown, A Korotzer, JA Zack
Journal of virology 76 (16), 8118-8123, 2002
2842002
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
DG Brooks, SJ Ha, H Elsaesser, AH Sharpe, GJ Freeman, MBA Oldstone
Proceedings of the National Academy of Sciences 105 (51), 20428-20433, 2008
2602008
Generation of HIV latency during thymopoiesis
DG Brooks, SG Kitchen, CMR Kitchen, DD Scripture-Adams, JA Zack
Nature medicine 7 (4), 459-464, 2001
2392001
Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype
DD Scripture-Adams, DG Brooks, YD Korin, JA Zack
Journal of Virology 76 (24), 13077-13082, 2002
2382002
Molecular characterization, reactivation, and depletion of latent HIV
DG Brooks, DH Hamer, PA Arlen, L Gao, G Bristol, CMR Kitchen, ...
Immunity 19 (3), 413-423, 2003
2352003
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
K Hezaveh, RS Shinde, A Klötgen, MJ Halaby, S Lamorte, R Quevedo, ...
Immunity 55 (2), 324-340. e8, 2022
2062022
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
DG Brooks, AM Lee, H Elsaesser, DB McGavern, MBA Oldstone
The Journal of experimental medicine 205 (3), 533-541, 2008
2012008
The role of IL-10 in regulating immunity to persistent viral infections
EB Wilson, DG Brooks
Negative Co-Receptors and Ligands, 39-65, 2011
1952011
IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
DG Brooks, KB Walsh, H Elsaesser, MBA Oldstone
Proceedings of the National Academy of Sciences 107 (7), 3018-3023, 2010
1822010
Targeting type I interferon–mediated activation restores immune function in chronic HIV infection
A Zhen, V Rezek, C Youn, B Lam, N Chang, J Rick, M Carrillo, H Martin, ...
The Journal of clinical investigation 127 (1), 260-268, 2017
1802017
Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
DG Brooks, DB McGavern, MBA Oldstone
The Journal of clinical investigation 116 (6), 1675-1685, 2006
1682006
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