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Yasser Aldhamen
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Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ...
Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013
1252013
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy
SS Seregin, DM Appledorn, AJ McBride, NJ Schuldt, YA Aldhamen, ...
Molecular Therapy 17 (4), 685-696, 2009
1112009
HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients
MD Rizzo, RB Crawford, JE Henriquez, YA Aldhamen, P Gulick, ...
Aids 32 (4), 419-429, 2018
732018
Sublingual administration of an adenovirus serotype 5 (Ad5)-based vaccine confirms Toll-like receptor agonist activity in the oral cavity and elicits improved mucosal and …
DM Appledorn, YA Aldhamen, S Godbehere, SS Seregin, A Amalfitano
Clinical and Vaccine Immunology 18 (1), 150-160, 2011
572011
Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells
YA Aldhamen, Y Pepelyayeva, DPW Rastall, SS Seregin, E Zervoudi, ...
Journal of innate immunity 7 (3), 275-289, 2015
482015
SLAMF7 signaling reprograms T cells toward exhaustion in the tumor microenvironment
P O’Connell, S Hyslop, MK Blake, S Godbehere, A Amalfitano, ...
The Journal of Immunology 206 (1), 193-205, 2021
472021
Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector–triggered immune responses in vitro and in vivo
SS Seregin, YA Aldhamen, DM Appledorn, ZC Hartman, NJ Schuldt, ...
Blood, The Journal of the American Society of Hematology 116 (10), 1669-1677, 2010
442010
A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target
DM Appledorn, YA Aldhamen, W DePas, SS Seregin, CJJ Liu, N Schuldt, ...
PLoS One 5 (3), e9579, 2010
422010
Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens
YA Aldhamen, DM Appledorn, SS Seregin, CJ Liu, NJ Schuldt, ...
The Journal of Immunology 186 (2), 722-732, 2011
412011
Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice
SS Seregin, YA Aldhamen, DPW Rastall, S Godbehere, A Amalfitano
Vaccine 30 (8), 1492-1501, 2012
402012
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response
YA Aldhamen, SS Seregin, DPW Rastall, CF Aylsworth, Y Pepelyayeva, ...
PloS one 8 (7), e69539, 2013
382013
Systemic innate and adaptive immune responses to SARS-CoV-2 as it relates to other coronaviruses
P O’Connell, YA Aldhamen
Human Vaccines & Immunotherapeutics 16 (12), 2980-2991, 2020
352020
SLAMF7 is a critical negative regulator of IFN-α–Mediated CXCL10 production in chronic HIV infection
P O’Connell, Y Pepelyayeva, MK Blake, S Hyslop, RB Crawford, ...
The Journal of Immunology 202 (1), 228-238, 2019
342019
ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis
Y Pepelyayeva, DPW Rastall, YA Aldhamen, P O’Connell, S Raehtz, ...
Scientific reports 8 (1), 12464, 2018
292018
Immune recognition of gene transfer vectors: focus on adenovirus as a paradigm
YA Aldhamen, SS Seregin, A Amalfitano
Frontiers in immunology 2, 40, 2011
282011
Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus
DPW Rastall, SS Seregin, YA Aldhamen, LM Kaiser, C Mullins, A Liou, ...
Gene Therapy 23 (10), 743-752, 2016
242016
CR1/2 is an important suppressor of Adenovirus-induced innate immune responses and is required for induction of neutralizing antibodies
SS Seregin, YA Aldhamen, DM Appledorn, NJ Schuldt, AJ McBride, ...
Gene therapy 16 (10), 1245-1259, 2009
242009
ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory …
DPW Rastall, YA Aldhamen, SS Seregin, S Godbehere, A Amalfitano
International immunology 26 (12), 685-695, 2014
232014
Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy
YA Aldhamen, SS Seregin, CF Aylsworth, S Godbehere, A Amalfitano
International immunology 26 (5), 291-303, 2014
212014
TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo
SS Seregin, YA Aldhamen, DM Appledorn, CF Aylsworth, S Godbehere, ...
PloS one 6 (7), e22064, 2011
212011
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