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Zhongkai Wang
Zhongkai Wang
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The development of chronic critical illness determines physical function, quality of life, and long-term survival among early survivors of sepsis in surgical ICUs
AK Gardner, GL Ghita, Z Wang, T Ozrazgat-Baslanti, SL Raymond, ...
Critical care medicine 47 (4), 566-573, 2019
1262019
Evidence for persistent immune suppression in patients who develop chronic critical illness after sepsis
JA Stortz, TJ Murphy, SL Raymond, JC Mira, R Ungaro, ML Dirain, ...
Shock 49 (3), 249-258, 2018
1232018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients
JA Stortz, JC Mira, SL Raymond, TJ Loftus, T Ozrazgat-Baslanti, Z Wang, ...
Journal of Trauma and Acute Care Surgery 84 (2), 342-349, 2018
1112018
The epidemiology of chronic critical illness after severe traumatic injury at two level–one trauma centers
JC Mira, J Cuschieri, T Ozrazgat-Baslanti, Z Wang, GL Ghita, TJ Loftus, ...
Critical care medicine 45 (12), 1989-1996, 2017
1022017
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis
MKK Hollen, JA Stortz, D Darden, ML Dirain, DC Nacionales, RB Hawkins, ...
Critical Care 23, 1-16, 2019
722019
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients
TJ Loftus, JC Mira, T Ozrazgat-Baslanti, GL Ghita, Z Wang, JA Stortz, ...
BMJ open 7 (7), e015136, 2017
692017
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients
SC Brakenridge, PA Efron, JA Stortz, T Ozrazgat-Baslanti, G Ghita, ...
Journal of Trauma and Acute Care Surgery 85 (2), 247-255, 2018
542018
The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis
MC Cox, M Booth, G Ghita, Z Wang, A Gardner, RB Hawkins, DB Darden, ...
Journal of cachexia, sarcopenia and muscle 12 (5), 1203-1213, 2021
422021
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma
JA Stortz, RB Hawkins, DC Holden, SL Raymond, Z Wang, ...
Scientific reports 9 (1), 13648, 2019
332019
Old mice demonstrate organ dysfunction as well as prolonged inflammation, immunosuppression, and weight loss in a modified surgical sepsis model
JA Stortz, MKK Hollen, DC Nacionales, H Horiguchi, R Ungaro, ML Dirain, ...
Critical care medicine 47 (11), e919-e929, 2019
322019
Chronic critical illness patients fail to respond to current evidence‐based intensive care nutrition secondarily to persistent inflammation, immunosuppression, and catabolic …
MD Rosenthal, T Bala, Z Wang, T Loftus, F Moore
Journal of Parenteral and Enteral Nutrition 44 (7), 1237-1249, 2020
292020
Persistent inflammation and anemia among critically ill septic patients
TJ Loftus, JC Mira, JA Stortz, T Ozrazgat-Baslanti, GL Ghita, Z Wang, ...
Journal of Trauma and Acute Care Surgery 86 (2), 260-267, 2019
292019
Prospective validation of a transcriptomic metric in severe trauma
SL Raymond, RB Hawkins, Z Wang, JC Mira, JA Stortz, F Han, JD Lanz, ...
Annals of surgery 271 (5), 802-810, 2020
282020
Delayed interhospital transfer of critically ill patients with surgical sepsis
TJ Loftus, Q Wu, Z Wang, N Lysak, FA Moore, A Bihorac, PA Efron, ...
Journal of Trauma and Acute Care Surgery 88 (1), 169-175, 2020
192020
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock
SC Brakenridge, Z Wang, M Cox, S Raymond, R Hawkins, D Darden, ...
Journal of Trauma and Acute Care Surgery 90 (2), 257-267, 2021
152021
Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial
AV Ramanan, P Quartier, N Okamoto, I Foeldvari, A Spindler, ...
The Lancet 402 (10401), 555-570, 2023
142023
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness
RB Hawkins, JA Stortz, DC Holden, Z Wang, SL Raymond, MC Cox, ...
Surgery 167 (3), 646-652, 2020
102020
Chronic critical illness elicits a unique circulating leukocyte transcriptome in sepsis survivors
DB Darden, GL Ghita, Z Wang, JA Stortz, MC Lopez, MC Cox, ...
Journal of Clinical Medicine 10 (15), 3211, 2021
82021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis
PA Efron, DB Darden, Z Wang, DC Nacionales, MC Lopez, RB Hawkins, ...
FASEB journal: official publication of the Federation of American Societies …, 2021
82021
Identification of unique mRNA and miRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after trauma in older adults
DB Darden, JA Stortz, MKK Hollen, MC Cox, CG Apple, RB Hawkins, ...
Frontiers in Immunology 11, 1289, 2020
82020
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