John C. Castle

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Jason M. JohnsonDana-Farber Cancer Institute, Stanford, Harvard, Pfizer, Merck, PatientsLikeMeVerified email at dfci.harvard.edu
Ugur SahinProfessor of ImmunologyVerified email at uni-mainz.de
Dr. Sebastian Boegelmedical student, Bioinformatician, University Hospital MainzVerified email at students.uni-mainz.de
Mustafa DikenTRON - Translational Oncology at University Medical Center of Johannes Gutenberg UniversityVerified email at tron-mainz.de
Sebastian KreiterTRON Translational Oncology MainzVerified email at tron-mainz.de
Zhengyan 'George' KanDirector of Computational Biology, Pfizer Inc.Verified email at pfizer.com
Özlem TüreciVerified email at uni-mainz.de
Patrick LoerchMerck & CoVerified email at merck.com
Eric SchadtProfessor of Genetics and Genomic Sciences, Mount Sinai School of MedicineVerified email at mssm.edu
Thomas BukurTRON - Translational Oncology at the Medical Center of the Johannes Gutenberg-University MainzVerified email at tron-mainz.de
Peter LinsleyMember and Center Director | Systems Immunology Benaroya Research Institute at Virginia Mason 1201Verified email at benaroyaresearch.org
Thomas A CooperBaylor College of MedicineVerified email at bcm.edu
NELSON LAUBoston University School of Medicine, Dept Biochemistry,Verified email at bu.edu
David BartelProfessor of Biology, HHMI, MIT, Whitehead InstituteVerified email at wi.mit.edu
Andrew GrimsonCornell University, Dept. of Molecular Biology and GeneticsVerified email at cornell.edu
Stephen EdwardsRTI InternationalVerified email at rti.org
Kenneth C CreagerProfessor of Earth and Space Sciences, University of WashingtonVerified email at uw.edu
Mohamed UdumanDirector, Immuno-Oncology Computational Biology, Dana-Farber Cancer InstituteVerified email at dfci.harvard.edu
Bernhard RenardHasso Plattner InstituteVerified email at hpi.de
Huda ZoghbiProfessor Baylor College of MedicineVerified email at bcm.edu

John C. Castle

Chief Data Scientist, Monte Rosa Therapeutics

Verified email at monterosatx.com - Homepage

computational biology NGS genomics degraders


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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs LP Lim, NC Lau, P Garrett-Engele, A Grimson, JM Schelter, J Castle, ... Nature 433 (7027), 769-773, 2005	5790	2005
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays JM Johnson, J Castle, P Garrett-Engele, Z Kan, PM Loerch, CD Armour, ... Science 302 (5653), 2141-2144, 2003	1791	2003
An integrative genomics approach to infer causal associations between gene expression and disease EE Schadt, J Lamb, X Yang, J Zhu, S Edwards, D GuhaThakurta, ... Nature genetics 37 (7), 710-717, 2005	1171	2005
Mutant MHC class II epitopes drive therapeutic immune responses to cancer S Kreiter, M Vormehr, N Van de Roemer, M Diken, M Löwer, J Diekmann, ... Nature 520 (7549), 692-696, 2015	1080	2015
Genome-scale RNAi screen for host factors required for HIV replication H Zhou, M Xu, Q Huang, AT Gates, XD Zhang, JC Castle, E Stec, M Ferrer, ... Cell host & microbe 4 (5), 495-504, 2008	894	2008
Exploiting the Mutanome for Tumor VaccinationB16 Melanoma T-cell–Druggable Mutanome JC Castle, S Kreiter, J Diekmann, M Löwer, N Van de Roemer, J de Graaf, ... Cancer research 72 (5), 1081-1091, 2012	834	2012
Experimental annotation of the human genome using microarray technology DD Shoemaker, EE Schadt, CD Armour, YD He, P Garrett-Engele, ... Nature 409 (6822), 922-927, 2001	607	2001
Actively personalized vaccination trial for newly diagnosed glioblastoma N Hilf, S Kuttruff-Coqui, K Frenzel, V Bukur, S Stevanović, ... Nature 565 (7738), 240-245, 2019	582	2019
Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2 JI Young, EP Hong, JC Castle, J Crespo-Barreto, AB Bowman, MF Rose, ... Proceedings of the national academy of sciences 102 (49), 17551-17558, 2005	534	2005
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart A Kalsotra, X Xiao, AJ Ward, JC Castle, JM Johnson, CB Burge, ... Proceedings of the National Academy of Sciences 105 (51), 20333-20338, 2008	508	2008
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines JC Castle, C Zhang, JK Shah, AV Kulkarni, A Kalsotra, TA Cooper, ... Nature genetics 40 (12), 1416-1425, 2008	348	2008
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2 C Zhang, Z Zhang, J Castle, S Sun, J Johnson, AR Krainer, MQ Zhang Genes & development 22 (18), 2550-2563, 2008	319	2008
Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma JC Castle, M Loewer, S Boegel, J de Graaf, C Bender, AD Tadmor, ... BMC genomics 15 (1), 1-12, 2014	317	2014
Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition K Bleasby, JC Castle, CJ Roberts, C Cheng, WJ Bailey, JF Sina, ... Xenobiotica 36 (10-11), 963-988, 2006	300	2006
Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling X Peng, L Gralinski, CD Armour, MT Ferris, MJ Thomas, S Proll, ... MBio 1 (5), e00206-10, 2010	252	2010
HLA typing from RNA-Seq sequence reads S Boegel, M Löwer, M Schäfer, T Bukur, J De Graaf, V Boisguérin, ... Genome medicine 4, 1-12, 2013	244	2013
Digital transcriptome profiling using selective hexamer priming for cDNA synthesis CD Armour, JC Castle, R Chen, T Babak, P Loerch, S Jackson, JK Shah, ... Nature methods 6 (9), 647-649, 2009	228	2009
Comparative expression pathway analysis of human and canine mammary tumors P Uva, L Aurisicchio, J Watters, A Loboda, A Kulkarni, J Castle, ... BMC genomics 10 (1), 1-20, 2009	187	2009
RNA-Seq Atlas—a reference database for gene expression profiling in normal tissue by next-generation sequencing M Krupp, JU Marquardt, U Sahin, PR Galle, J Castle, A Teufel Bioinformatics 28 (8), 1184-1185, 2012	180	2012
Definition, conservation and epigenetics of housekeeping and tissue-enriched genes X She, CA Rohl, JC Castle, AV Kulkarni, JM Johnson, R Chen BMC genomics 10, 1-12, 2009	174	2009

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