| Generalized potential of adult neural stem cells DL Clarke, CB Johansson, J Wilbertz, B Veress, E Nilsson, H Karlström, ... Science 288 (5471), 1660-1663, 2000 | 1671 | 2000 |
| Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration–motor neuron disease AA Luty, JBJ Kwok, C Dobson‐Stone, CT Loy, KG Coupland, H Karlström, ... Annals of neurology 68 (5), 639-649, 2010 | 224 | 2010 |
| Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production NS Leal, B Schreiner, CM Pinho, R Filadi, B Wiehager, H Karlström, ... Journal of cellular and molecular medicine 20 (9), 1686-1695, 2016 | 159 | 2016 |
| A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling H Karlström, P Beatus, K Dannaeus, G Chapman, U Lendahl, J Lundkvist Proceedings of the National Academy of Sciences 99 (26), 17119-17124, 2002 | 146 | 2002 |
| A sensitive and quantitative assay for measuring cleavage of presenilin substrates H Karlström, A Bergman, U Lendahl, J Näslund, J Lundkvist Journal of Biological Chemistry 277 (9), 6763-6766, 2002 | 111 | 2002 |
| Variable phenotype of Alzheimer’s disease with spastic paraparesis H Karlstrom, WS Brooks, JBJ Kwok, GA Broe, JJ Kril, H McCann, ... Journal of neurochemistry 104 (3), 573-583, 2008 | 80 | 2008 |
| Notch receptor cleavage depends on but is not directly executed by presenilins Y Taniguchi, H Karlström, J Lundkvist, T Mizutani, A Otaka, M Vestling, ... Proceedings of the National Academy of Sciences 99 (6), 4014-4019, 2002 | 80 | 2002 |
| Co‐expressed presenilin 1 NTF and CTF form functional γ‐secretase complexes in cells devoid of full‐length protein H Laudon, PM Mathews, H Karlström, A Bergman, MR Farmery, RA Nixon, ... Journal of neurochemistry 89 (1), 44-53, 2004 | 68 | 2004 |
| Generation and phenotypic characterization of a galanin overexpressing mouse K Holmberg, E Kuteeva, P Brumovsky, U Kahl, H Karlström, GA Lucas, ... Neuroscience 133 (1), 59-77, 2005 | 63 | 2005 |
| Mice carrying a R142C Notch 3 knock–in mutation do not develop a CADASIL‐like phenotype J Lundkvist, S Zhu, EM Hansson, P Schweinhardt, Q Miao, P Beatus, ... Genesis 41 (1), 13-22, 2005 | 53 | 2005 |
| Role of NOTCH3 mutations in the cerebral small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy K Coupland, U Lendahl, H Karlström Stroke 49 (11), 2793-2800, 2018 | 52 | 2018 |
| Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy T Borgegård, S Gustavsson, C Nilsson, S Parpal, R Klintenberg, AL Berg, ... Journal of Neuroscience 32 (48), 17297-17305, 2012 | 49 | 2012 |
| APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer’s disease mutations A Bergman, D Religa, H Karlström, H Laudon, B Winblad, L Lannfelt, ... Experimental cell research 287 (1), 1-9, 2003 | 48 | 2003 |
| Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain J Frånberg, AI Svensson, B Winblad, H Karlström, S Frykman Biochemical and biophysical research communications 404 (1), 564-568, 2011 | 33 | 2011 |
| Specificity of Presenilin‐1‐and Presenilin‐2‐dependent γ‐secretases towards Substrate Processing S Stanga, C Vrancx, B Tasiaux, C Marinangeli, H Karlström, ... Journal of cellular and molecular medicine 22 (2), 823-833, 2018 | 28 | 2018 |
| Functional domains in presenilin 1: the Tyr-288 residue controls γ-secretase activity and endoproteolysis H Laudon, H Karlström, PM Mathews, MR Farmery, SE Gandy, ... Journal of Biological Chemistry 279 (23), 23925-23932, 2004 | 27 | 2004 |
| Second generation γ-secretase modulators exhibit different modulation of notch β and Aβ production J Wanngren, J Ottervald, S Parpal, E Portelius, K Strömberg, T Borgegård, ... Journal of Biological Chemistry 287 (39), 32640-32650, 2012 | 25 | 2012 |
| Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations J Wanngren, P Lara, K Öjemalm, S Maioli, N Moradi, L Chen, ... FEBS open bio 4, 393-406, 2014 | 23 | 2014 |
| Mutations in nicastrin protein differentially affect amyloid β-peptide production and Notch protein processing A Pamrén, J Wanngren, LO Tjernberg, B Winblad, R Bhat, J Näslund, ... Journal of Biological Chemistry 286 (36), 31153-31158, 2011 | 23 | 2011 |
| The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch … J Wanngren, J Frånberg, AI Svensson, H Laudon, F Olsson, B Winblad, ... Journal of biological chemistry 285 (12), 8527-8536, 2010 | 19 | 2010 |
