| A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage A Bach, BH Clausen, M Møller, B Vestergaard, CN Chi, A Round, ... Proceedings of the National Academy of Sciences 109 (9), 3317-3322, 2012 | 213 | 2012 |
| Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein AI S Bibow, Y Polyhach, C Eichmann, CN Chi, J Kowal, S Albiez, ... Nature structural & molecular biology 24 (2), 187-193, 2017 | 138 | 2017 |
| Reassessing a sparse energetic network within a single protein domain CN Chi, L Elfström, Y Shi, T Snäll, Å Engström, P Jemth Proceedings of the National Academy of Sciences 105 (12), 4679-4684, 2008 | 105 | 2008 |
| The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism S Gianni, A Engström, M Larsson, N Calosci, F Malatesta, L Eklund, ... Journal of Biological Chemistry 280 (41), 34805-34812, 2005 | 105 | 2005 |
| Modified Peptides as Potent Inhibitors of the Postsynaptic Density-95/N-Methyl-d-Aspartate Receptor Interaction A Bach, CN Chi, TB Olsen, SW Pedersen, MU Røder, GF Pang, ... Journal of medicinal chemistry 51 (20), 6450-6459, 2008 | 81 | 2008 |
| Ligand binding by PDZ domains CN Chi, A Bach, K Strømgaard, S Gianni, P Jemth Biofactors 38 (5), 338-348, 2012 | 75 | 2012 |
| Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins N Calosci, CN Chi, B Richter, C Camilloni, Å Engström, L Eklund, ... Proceedings of the National Academy of Sciences 105 (49), 19241-19246, 2008 | 71 | 2008 |
| Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity S Gianni, SR Haq, LC Montemiglio, MC Jürgens, Å Engström, CN Chi, ... Journal of Biological Chemistry 286 (31), 27167-27175, 2011 | 68 | 2011 |
| Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction A Bach, CN Chi, GF Pang, L Olsen, AS Kristensen, P Jemth, ... Angewandte Chemie International Edition 48 (51), 9685-9689, 2009 | 66 | 2009 |
| Two conserved residues govern the salt and pH dependencies of the binding reaction of a PDZ domain CN Chi, A Engstrom, S Gianni, M Larsson, P Jemth Journal of biological chemistry 281 (48), 36811-36818, 2006 | 62 | 2006 |
| A conserved folding mechanism for PDZ domains CN Chi, S Gianni, N Calosci, C Travaglini-Allocatelli, Å Engström, P Jemth FEBS letters 581 (6), 1109-1113, 2007 | 60 | 2007 |
| Proteome‐wide analysis of phospho‐regulated PDZ domain interactions GN Sundell, R Arnold, M Ali, P Naksukpaiboon, J Orts, P Güntert, CN Chi, ... Molecular systems biology 14 (8), e8129, 2018 | 56 | 2018 |
| A sequential binding mechanism in a PDZ domain CN Chi, A Bach, Å Engström, H Wang, K Strømgaard, S Gianni, P Jemth Biochemistry 48 (30), 7089-7097, 2009 | 50 | 2009 |
| Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability A Daskalov, M Gantner, MA Wälti, T Schmidlin, CN Chi, C Wasmer, ... PLoS pathogens 10 (6), e1004158, 2014 | 49 | 2014 |
| The transition state of coupled folding and binding for a flexible β-finger OA Karlsson, CN Chi, Å Engström, P Jemth Journal of molecular biology 417 (3), 253-261, 2012 | 46 | 2012 |
| Emergence and evolution of an interaction between intrinsically disordered proteins G Hultqvist, E Åberg, C Camilloni, GN Sundell, E Andersson, J Dogan, ... Elife 6, e16059, 2017 | 44 | 2017 |
| Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains SR Haq, CN Chi, A Bach, J Dogan, Å Engström, G Hultqvist, ... Journal of the American Chemical Society 134 (1), 599-605, 2012 | 44 | 2012 |
| A structural ensemble for the enzyme cyclophilin reveals an orchestrated mode of action at atomic resolution CN Chi, B Vögeli, S Bibow, D Strotz, J Orts, P Güntert, R Riek Angewandte Chemie International Edition 54 (40), 11657-11661, 2015 | 41 | 2015 |
| Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins P Jemth, E Karlsson, B Vögeli, B Guzovsky, E Andersson, G Hultqvist, ... Science advances 4 (10), eaau4130, 2018 | 40 | 2018 |
| Towards a true protein movie: a perspective on the potential impact of the ensemble-based structure determination using exact NOEs B Vögeli, J Orts, D Strotz, C Chi, M Minges, MA Wälti, P Güntert, R Riek Journal of magnetic resonance 241, 53-59, 2014 | 39 | 2014 |
Kristian StrømgaardProfessor i kemisk biologi, Københavns UniversitetBestätigte E-Mail-Adresse bei sund.ku.dk
