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Johan H. van Es
Johan H. van Es
KNAW Hubrecht Institute
Bestätigte E-Mail-Adresse bei hubrecht.eu
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262-265, 2009
67042009
Identification of stem cells in small intestine and colon by marker gene Lgr5
N Barker, JH Van Es, J Kuipers, P Kujala, M Van Den Born, M Cozijnsen, ...
Nature 449 (7165), 1003-1007, 2007
61882007
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ...
Gastroenterology 141 (5), 1762-1772, 2011
34792011
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415-418, 2011
27272011
Crypt stem cells as the cells-of-origin of intestinal cancer
N Barker, RA Ridgway, JH Van Es, M Van De Wetering, H Begthel, ...
Nature 457 (7229), 608-611, 2009
24472009
Caught up in a Wnt storm: Wnt signaling in cancer
RH Giles, JH Van Es, H Clevers
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1653 (1), 1-24, 2003
20322003
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ...
Cell 143 (1), 134-144, 2010
20072010
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
JH van Es, ME Van Gijn, O Riccio, M Van Den Born, M Vooijs, H Begthel, ...
Nature 435 (7044), 959-963, 2005
18342005
Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ...
Cell stem cell 6 (1), 25-36, 2010
17272010
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ...
Nature 494 (7436), 247-250, 2013
15612013
Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
M Van de Wetering, R Cavallo, D Dooijes, M van Beest, J van Es, ...
Cell 88 (6), 789-799, 1997
15161997
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ...
Nature 476 (7360), 293-297, 2011
13942011
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
AG Schepers, HJ Snippert, DE Stange, M van den Born, JH van Es, ...
Science 337 (6095), 730-735, 2012
12402012
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
V Jaks, N Barker, M Kasper, JH Van Es, HJ Snippert, H Clevers, ...
Nature genetics 40 (11), 1291-1299, 2008
11032008
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ...
Nature 488 (7413), 665-669, 2012
9712012
Mutations in the APC tumour suppressor gene cause chromosomal instability
R Fodde, J Kuipers, C Rosenberg, R Smits, M Kielman, C Gaspar, ...
Nature cell biology 3 (4), 433-438, 2001
9472001
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
APG Haramis, H Begthel, M Van Den Born, J Van Es, S Jonkheer, ...
Science 303 (5664), 1684-1686, 2004
9442004
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
HJ Snippert, A Haegebarth, M Kasper, V Jaks, JH van Es, N Barker, ...
Science 327 (5971), 1385-1389, 2010
8682010
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ...
Nature cell biology 14 (10), 1099-1104, 2012
8182012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers
J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ...
The EMBO journal 31 (14), 3079-3091, 2012
8182012
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