| A long noncoding RNA protects the heart from pathological hypertrophy P Han, W Li, CH Lin, J Yang, C Shang, ST Nurnberg, KK Jin, W Xu, ... Nature 514 (7520), 102-106, 2014 | 780 | 2014 |
| OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin L Chen, Y Shu, X Liang, EC Chen, SW Yee, AA Zur, S Li, L Xu, ... Proceedings of the National Academy of Sciences 111 (27), 9983-9988, 2014 | 226 | 2014 |
| Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin K Zhou, SW Yee, EL Seiser, N Van Leeuwen, R Tavendale, AJ Bennett, ... Nature genetics 48 (9), 1055-1059, 2016 | 198 | 2016 |
| Rate of evolution in brain-expressed genes in humans and other primates HY Wang, HC Chien, N Osada, K Hashimoto, S Sugano, T Gojobori, ... PLoS biology 5 (2), e13, 2007 | 130 | 2007 |
| Metformin is a substrate and inhibitor of the human thiamine transporter, THTR-2 (SLC19A3) X Liang, HC Chien, SW Yee, MM Giacomini, EC Chen, M Piao, J Hao, ... Molecular pharmaceutics 12 (12), 4301-4310, 2015 | 106 | 2015 |
| Reevaluating the substrate specificity of the L-type amino acid transporter (LAT1) HC Chien, C Colas, K Finke, S Springer, L Stoner, AA Zur, B Venteicher, ... Journal of medicinal chemistry 61 (16), 7358-7373, 2018 | 72 | 2018 |
| Discovery of competitive and noncompetitive ligands of the organic cation transporter 1 (OCT1; SLC22A1) EC Chen, N Khuri, X Liang, A Stecula, HC Chien, SW Yee, Y Huang, ... Journal of medicinal chemistry 60 (7), 2685-2696, 2017 | 65 | 2017 |
| Rapid method to determine intracellular drug concentrations in cellular uptake assays: application to metformin in organic cation transporter 1–transfected human embryonic … HC Chien, AA Zur, TS Maurer, SW Yee, J Tolsma, P Jasper, DO Scott, ... Drug Metabolism and Disposition 44 (3), 356-364, 2016 | 61 | 2016 |
| Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content X Liang, SW Yee, HC Chien, EC Chen, Q Luo, L Zou, M Piao, A Mifune, ... PLoS biology 16 (4), e2002907, 2018 | 56 | 2018 |
| A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568 P Yang, Y Wang, D Hoang, M Tinkham, A Patel, MA Sun, G Wolf, M Baker, ... Science 356 (6339), 757-759, 2017 | 55 | 2017 |
| LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs E Augustyn, K Finke, AA Zur, L Hansen, N Heeren, HC Chien, L Lin, ... Bioorganic & medicinal chemistry letters 26 (11), 2616-2621, 2016 | 48 | 2016 |
| Prediction and validation of enzyme and transporter off-targets for metformin SW Yee, L Lin, M Merski, MJ Keiser, A Gupta, Y Zhang, HC Chien, ... Journal of pharmacokinetics and pharmacodynamics 42, 463-475, 2015 | 47 | 2015 |
| Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives L Zou, P Spanogiannopoulos, LM Pieper, HC Chien, W Cai, N Khuri, ... Proceedings of the National Academy of Sciences 117 (27), 16009-16018, 2020 | 45 | 2020 |
| Molecular mechanisms for species differences in organic anion transporter 1, OAT1: implications for renal drug toxicity L Zou, A Stecula, A Gupta, B Prasad, HC Chien, SW Yee, L Wang, ... Molecular pharmacology 94 (1), 689-699, 2018 | 44 | 2018 |
| LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates AA Zur, HC Chien, E Augustyn, A Flint, N Heeren, K Finke, C Hernandez, ... Bioorganic & medicinal chemistry letters 26 (20), 5000-5006, 2016 | 43 | 2016 |
| Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies GKM Yee SW, Stecula A, Chien HC, Zou L, Irannejad R, Borselen M, Feofanova ... PLoS Genet, 2019 | 24 | 2019 |
| Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies SW Yee, D Buitrago, A Stecula, HX Ngo, HC Chien, L Zou, ML Koleske, ... FASEB journal: official publication of the Federation of American Societies …, 2020 | 23 | 2020 |
| Mutations in the fourth β‐propeller domain of LRP4 are associated with isolated syndactyly with fusion of the third and fourth fingers R Sukenik Halevy, HC Chien, B Heinz, MJ Bamshad, DA Nickerson, ... Human mutation 39 (6), 811-815, 2018 | 20 | 2018 |
| Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage HC Chien, HY Wang, YN Su, KY Lai, LC Lu, PC Chen, SF Tsai, CI Wu, ... Public Library of Science 7 (10), e47481, 2012 | 14 | 2012 |
| l-Type amino acid transporter 1 activity of 1, 2, 3-triazolyl analogs of l-histidine and l-tryptophan C Hall, H Wolfe, A Wells, HC Chien, C Colas, A Schlessinger, ... Bioorganic & medicinal chemistry letters 29 (16), 2254-2258, 2019 | 11 | 2019 |
