Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1455 | 2013 |
Adverse outcome pathways: opportunities, limitations and open questions M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ... Archives of Toxicology 91, 3477-3505, 2017 | 359 | 2017 |
Hepatocyte-specific Smad7 expression attenuates TGF-β–mediated fibrogenesis and protects against liver damage S Dooley, J Hamzavi, L Ciuclan, P Godoy, I Ilkavets, S Ehnert, ... Gastroenterology 135 (2), 642-659. e46, 2008 | 350 | 2008 |
TGF-β/Smad signaling in the injured liver K Breitkopf, P Godoy, L Ciuclan, MV Singer, S Dooley Zeitschrift für Gastroenterologie 44 (01), 57-66, 2006 | 302 | 2006 |
Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis P Godoy, JG Hengstler, I Ilkavets, C Meyer, A Bachmann, A Müller, ... Hepatology 49 (6), 2031-2043, 2009 | 301 | 2009 |
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells P Godoy, W Schmidt-Heck, K Natarajan, B Lucendo-Villarin, D Szkolnicka, ... Journal of hepatology 63 (4), 934-942, 2015 | 200 | 2015 |
The etiology of liver damage imparts cytokines transforming growth factor β1 or interleukin‐13 as driving forces in fibrogenesis HL Weng, Y Liu, JL Chen, T Huang, LJ Xu, P Godoy, JH Hu, C Zhou, ... Hepatology 50 (1), 230-243, 2009 | 178 | 2009 |
Interactome screening identifies the ER luminal chaperone Hsp47 as a regulator of the unfolded protein response transducer IRE1α D Sepulveda, D Rojas-Rivera, DA Rodríguez, J Groenendyk, A Köhler, ... Molecular cell 69 (2), 238-252. e7, 2018 | 167 | 2018 |
Recombinant laminins drive the differentiation and self-organization of hESC-derived hepatocytes K Cameron, R Tan, W Schmidt-Heck, G Campos, MJ Lyall, Y Wang, ... Stem cell reports 5 (6), 1250-1262, 2015 | 160 | 2015 |
Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways U Klingmüller, A Bauer, S Bohl, PJ Nickel, K Breitkopf, S Dooley, ... IEE Proceedings-Systems Biology 153 (6), 433-447, 2006 | 157 | 2006 |
Profibrogenic transforming growth factor‐β/activin receptor–like kinase 5 signaling via connective tissue growth factor expression in hepatocytes HL Weng, L Ciuclan, Y Liu, J Hamzavi, P Godoy, H Gaitantzi, S Kanzler, ... Hepatology 46 (4), 1257-1270, 2007 | 154 | 2007 |
Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue … S Hammad, S Hoehme, A Friebel, I von Recklinghausen, A Othman, ... Archives of toxicology 88, 1161-1183, 2014 | 152 | 2014 |
Toxicogenomics directory of chemically exposed human hepatocytes M Grinberg, RM Stöber, K Edlund, E Rempel, P Godoy, R Reif, A Widera, ... Archives of toxicology 88, 2261-2287, 2014 | 150 | 2014 |
The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening JP Frimat, J Sisnaiske, S Subbiah, H Menne, P Godoy, P Lampen, M Leist, ... Lab on a Chip 10 (6), 701-709, 2010 | 140 | 2010 |
Transcription factors ETF, E2F, and SP‐1 are involved in cytokine‐independent proliferation of murine hepatocytes S Zellmer, W Schmidt‐Heck, P Godoy, H Weng, C Meyer, T Lehmann, ... Hepatology 52 (6), 2127-2136, 2010 | 128 | 2010 |
Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases A Ghallab, G Celliere, SG Henkel, D Driesch, S Hoehme, U Hofmann, ... Journal of hepatology 64 (4), 860-871, 2016 | 118 | 2016 |
Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue P Godoy, A Widera, W Schmidt-Heck, G Campos, C Meyer, C Cadenas, ... Archives of toxicology 90, 2513-2529, 2016 | 116 | 2016 |
Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ... Hepatology 69 (2), 666-683, 2019 | 104 | 2019 |
Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response P Godoy, C Cadenas, B Hellwig, R Marchan, J Stewart, R Reif, M Lohr, ... Breast Cancer 21, 491-499, 2014 | 99 | 2014 |
Human hepatocytes: isolation, culture, and quality procedures D Knobeloch, S Ehnert, L Schyschka, P Büchler, M Schoenberg, J Kleeff, ... Human cell culture protocols, 99-120, 2012 | 82 | 2012 |