Carole Sourbier
Carole Sourbier
Principal Investigator, U.S. Food and Drug Administration
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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
S Yoshida, S Tsutsumi, G Muhlebach, C Sourbier, MJ Lee, S Lee, ...
Proceedings of the National Academy of Sciences 110 (17), E1604-E1612, 2013
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1α stabilization by glucose-dependent generation of …
S Sudarshan, C Sourbier, HS Kong, K Block, VAV Romero, Y Yang, ...
Molecular and cellular biology 29 (15), 4080-4090, 2009
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels
WH Tong, C Sourbier, G Kovtunovych, SY Jeong, M Vira, M Ghosh, ...
Cancer cell 20 (3), 315-327, 2011
The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy
C Sourbier, V Lindner, H Lang, A Agouni, E Schordan, S Danilin, ...
Cancer research 66 (10), 5130-5142, 2006
UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in …
Y Yang, VA Valera, HM Padilla-Nash, C Sourbier, CD Vocke, MA Vira, ...
Cancer genetics and cytogenetics 196 (1), 45-55, 2010
Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin CardiotoxicityMitochondrial Topoisomerase I Determines Doxorubicin Cardiotoxicity
S Khiati, I Dalla Rosa, C Sourbier, X Ma, VA Rao, LM Neckers, H Zhang, ...
Clinical Cancer Research 20 (18), 4873-4881, 2014
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism
C Douarre, C Sourbier, I Dalla Rosa, B Brata Das, CE Redon, H Zhang, ...
PloS one 7 (7), e41094, 2012
New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease
R Srinivasan, CJ Ricketts, C Sourbier, WM Linehan
Clinical cancer research 21 (1), 10-17, 2015
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma
Y Yang, AN Lane, CJ Ricketts, C Sourbier, MH Wei, B Shuch, L Pike, ...
PLoS One 8 (8), e72179, 2013
Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In VivoMGPDH Is a …
S Thakur, B Daley, K Gaskins, VV Vasko, M Boufraqech, D Patel, ...
Clinical cancer research 24 (16), 4030-4043, 2018
SDHB-deficient cancers: the role of mutations that impair iron sulfur cluster delivery
N Saxena, N Maio, DR Crooks, CJ Ricketts, Y Yang, MH Wei, TWM Fan, ...
JNCI: Journal of the National Cancer Institute 108 (1), 2016
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer
C Sourbier, CJ Ricketts, S Matsumoto, DR Crooks, PJ Liao, PZ Mannes, ...
Cancer cell 26 (6), 840-850, 2014
Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma
Y Lu, W Xu, J Ji, D Feng, C Sourbier, Y Yang, J Qu, Z Zeng, C Wang, ...
Hepatology 62 (4), 1122-1131, 2015
Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality
C Sourbier, BT Scroggins, R Ratnayake, TL Prince, S Lee, MJ Lee, ...
Cancer cell 23 (2), 228-237, 2013
Discovering targets of non-enzymatic acylation by thioester reactivity profiling
RA Kulkarni, AJ Worth, TT Zengeya, JH Shrimp, JM Garlick, AM Roberts, ...
Cell chemical biology 24 (2), 231-242, 2017
Targeting the nuclear factor-κB rescue pathway has promising future in human renal cell carcinoma therapy
C Sourbier, S Danilin, V Lindner, J Steger, S Rothhut, N Meyer, ...
Cancer research 67 (24), 11668-11676, 2007
Role of the RNA-binding protein HuR in human renal cell carcinoma
S Danilin, C Sourbier, L Thomas, V Lindner, S Rothhut, V Dormoy, ...
Carcinogenesis 31 (6), 1018-1026, 2010
Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration
S Khiati, SA Baechler, VM Factor, H Zhang, SYN Huang, I Dalla Rosa, ...
Proceedings of the National Academy of Sciences 112 (36), 11282-11287, 2015
The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and-Resistant MET-Driven Tumor ModelsHSP90 Inhibition Reverses …
N Miyajima, S Tsutsumi, C Sourbier, K Beebe, M Mollapour, C Rivas, ...
Cancer research 73 (23), 7022-7033, 2013
Parathyroid hormone-related protein in human renal cell carcinoma
C Sourbier, T Massfelder
Cancer letters 240 (2), 170-182, 2006
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