フォロー
Tomoya Sameshima
Tomoya Sameshima
所属不明
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引用先
引用先
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
Y Tanaka, K Aikawa, G Nishida, M Homma, S Sogabe, S Igaki, Y Hayano, ...
Journal of medicinal chemistry 56 (23), 9635-9645, 2013
1302013
K-Ras (G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology
K Sakamoto, Y Kamada, T Sameshima, M Yaguchi, A Niida, S Sasaki, ...
Biochemical and biophysical research communications 484 (3), 605-611, 2017
1232017
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation
N Ohoka, Y Morita, K Nagai, K Shimokawa, O Ujikawa, I Fujimori, M Ito, ...
Journal of Biological Chemistry 293 (18), 6776-6790, 2018
1152018
Development of protein degradation inducers of oncogenic BCR‐ABL protein by conjugation of ABL kinase inhibitors and IAP ligands
N Shibata, N Miyamoto, K Nagai, K Shimokawa, T Sameshima, N Ohoka, ...
Cancer science 108 (8), 1657-1666, 2017
1132017
Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation
K Shimokawa, N Shibata, T Sameshima, N Miyamoto, O Ujikawa, H Nara, ...
ACS medicinal chemistry letters 8 (10), 1042-1047, 2017
992017
Crystal structure of a human K-Ras G12D mutant in complex with GDP and the cyclic inhibitory peptide KRpep-2d
S Sogabe, Y Kamada, M Miwa, A Niida, T Sameshima, M Kamaura, ...
ACS medicinal chemistry letters 8 (7), 732-736, 2017
832017
Football-and Bullet-shaped GroEL-GroES Complexes Coexist during the Reaction Cycle*♦
T Sameshima, T Ueno, R Iizuka, N Ishii, N Terada, K Okabe, T Funatsu
Journal of Biological Chemistry 283 (35), 23765-23773, 2008
582008
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
N Shibata, K Shimokawa, K Nagai, N Ohoka, T Hattori, N Miyamoto, ...
Scientific reports 8 (1), 13549, 2018
572018
Rapid Determination of the Specificity Constant of Irreversible Inhibitors (kinact/KI) by Means of an Endpoint Competition Assay
I Miyahisa, T Sameshima, MS Hixon
Angewandte Chemie 127 (47), 14305-14308, 2015
562015
Denatured proteins facilitate the formation of the football-shaped GroEL–(GroES)2 complex
T Sameshima, R Iizuka, T Ueno, T Funatsu
Biochemical Journal 427 (2), 247-254, 2010
552010
Investigation of the structural requirements of K-Ras (G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging
A Niida, S Sasaki, K Yonemori, T Sameshima, M Yaguchi, T Asami, ...
Bioorganic & medicinal chemistry letters 27 (12), 2757-2761, 2017
522017
Single-molecule study on the decay process of the football-shaped GroEL-GroES complex using zero-mode waveguides
T Sameshima, R Iizuka, T Ueno, J Wada, M Aoki, N Shimamoto, ...
Journal of Biological Chemistry 285 (30), 23159-23164, 2010
522010
Discovery of 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12 …
M Ito, T Tanaka, A Toita, N Uchiyama, H Kokubo, N Morishita, MG Klein, ...
Journal of medicinal chemistry 61 (17), 7710-7728, 2018
492018
Different degradation mechanisms of inhibitor of apoptosis proteins (IAPs) by the specific and nongenetic IAP-dependent protein eraser (SNIPER)
N Ohoka, O Ujikawa, K Shimokawa, T Sameshima, N Shibata, T Hattori, ...
Chemical and Pharmaceutical Bulletin 67 (3), 203-209, 2019
462019
Identification of novel, potent, and orally available GCN2 inhibitors with type I half binding mode
J Fujimoto, O Kurasawa, T Takagi, X Liu, H Banno, T Kojima, Y Asano, ...
ACS Medicinal Chemistry Letters 10 (10), 1498-1503, 2019
402019
Discovery of an irreversible and cell-active BCL6 inhibitor selectively targeting Cys53 located at the protein–protein interaction interface
T Sameshima, T Yamamoto, O Sano, S Sogabe, S Igaki, K Sakamoto, ...
Biochemistry 57 (8), 1369-1379, 2018
272018
Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application
Y Hirozane, M Toyofuku, T Yogo, Y Tanaka, T Sameshima, I Miyahisa, ...
Bioorganic & medicinal chemistry letters 29 (21), 126641, 2019
172019
Small-scale panel comprising diverse gene family targets to evaluate compound promiscuity
T Sameshima, T Yukawa, Y Hirozane, M Yoshikawa, T Katoh, H Hara, ...
Chemical Research in Toxicology 33 (1), 154-161, 2019
132019
High-throughput quantitative intrinsic thiol reactivity evaluation using a fluorescence-based competitive endpoint assay
T Sameshima, I Miyahisa, S Yamasaki, M Gotou, T Kobayashi, ...
SLAS DISCOVERY: Advancing Life Sciences R&D 22 (9), 1168-1174, 2017
132017
Rapid multi-reagents exchange TIRFM microfluidic system for single biomolecular imaging
T Arakawa, T Sameshima, Y Sato, T Ueno, Y Shirasaki, T Funatsu, S Shoji
Sensors and Actuators B: Chemical 128 (1), 218-225, 2007
82007
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