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Patrick Maxwell
Patrick Maxwell
Professor of Medicine, University of Cambridge
Bestätigte E-Mail-Adresse bei medschl.cam.ac.uk
Titel
Zitiert von
Zitiert von
Jahr
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
P Jaakkola, DR Mole, YM Tian, MI Wilson, J Gielbert, SJ Gaskell, ...
Science 292 (5516), 468-472, 2001
64962001
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
PH Maxwell, MS Wiesener, GW Chang, SC Clifford, EC Vaux, ...
Nature 399 (6733), 271-275, 1999
61511999
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein, JM Gleadle, LA McNeill, KS Hewitson, J O'Rourke, DR Mole, ...
Cell 107 (1), 43-54, 2001
40112001
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
P Carmeliet, Y Dor, JM Herbert, D Fukumura, K Brusselmans, ...
Nature 394 (6692), 485-490, 1998
33751998
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks, H Turley, KC Gatter, PH Maxwell, CW Pugh, PJ Ratcliffe, ...
The American journal of pathology 157 (2), 411-421, 2000
17632000
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
CC Wykoff, NJP Beasley, PH Watson, KJ Turner, J Pastorek, A Sibtain, ...
Cancer research 60 (24), 7075-7083, 2000
15842000
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
PH Maxwell, GU Dachs, JM Gleadle, LG Nicholls, AL Harris, IJ Stratford, ...
Proceedings of the National Academy of Sciences 94 (15), 8104-8109, 1997
14041997
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman, N Masson, DR Mole, P Jaakkola, GW Chang, SC Clifford, ...
Journal of Biological Chemistry 275 (33), 25733-25741, 2000
13842000
Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation
N Masson, C Willam, PH Maxwell, CW Pugh, PJ Ratcliffe
The EMBO journal, 2001
13522001
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
RR Raval, KW Lau, MGB Tran, HM Sowter, SJ Mandriota, JL Li, CW Pugh, ...
Molecular and cellular biology, 2005
11752005
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
MS Wiesener, JS Jürgensen, C Rosenberger, C Scholze, JH Hörstrup, ...
The FASEB Journal 17 (2), 271-273, 2003
10022003
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
M Mazzone, D Dettori, RL de Oliveira, S Loges, T Schmidt, B Jonckx, ...
Cell 136 (5), 839-851, 2009
9222009
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
WC Hon, MI Wilson, K Harlos, TDW Claridge, CJ Schofield, CW Pugh, ...
Nature 417 (6892), 975-978, 2002
8622002
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α
MS Wiesener, H Turley, WE Allen, C Willam, KU Eckardt, KL Talks, ...
Blood, The Journal of the American Society of Hematology 92 (7), 2260-2268, 1998
8581998
Expression of hypoxia-inducible factor-1α and-2α in hypoxic and ischemic rat kidneys
C Rosenberger, S Mandriota, JS Ju, MS Wiesener, JH Ho, U Frei, ...
Journal of the American Society of Nephrology 13 (7), 1721-1732, 2002
6992002
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron
SJ Mandriota, KJ Turner, DR Davies, PG Murray, NV Morgan, HM Sowter, ...
Cancer cell 1 (5), 459-468, 2002
6232002
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
DA Collier, IATM Ferreira, P Kotagiri, RP Datir, EY Lim, E Touizer, B Meng, ...
Nature 596 (7872), 417-422, 2021
6152021
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
SO Ang, H Chen, K Hirota, VR Gordeuk, J Jelinek, Y Guan, E Liu, ...
Nature genetics 32 (4), 614-621, 2002
6132002
Activation of the HIF pathway in cancer
PH Maxwell, CW Pugh, PJ Ratcliffe
Current opinion in genetics & development 11 (3), 293-299, 2001
6022001
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
J Adam, E Hatipoglu, L O'Flaherty, N Ternette, N Sahgal, H Lockstone, ...
Cancer cell 20 (4), 524-537, 2011
6002011
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