Steffen Pockes
Steffen Pockes
University of Minnesota; University of Regensburg
Bestätigte E-Mail-Adresse bei
Zitiert von
Zitiert von
Synthesis, biological evaluation, and computational studies of Tri-and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and h H3 receptor antagonists
FH Darras, S Pockes, G Huang, S Wehle, A Strasser, HJ Wittmann, ...
ACS chemical neuroscience 5 (3), 225-242, 2014
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats
B Sadek, N Khan, FH Darras, S Pockes, M Decker
Physiology & behavior 165, 383-391, 2016
A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor
N Rosier, L Grätz, H Schihada, J Möller, A Isbilir, LJ Humphrys, M Nagl, ...
Journal of Medicinal Chemistry 64 (15), 11695-11708, 2021
Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists†
S Pockes, D Wifling, M Keller, A Buschauer, S Elz
ACS omega 3 (3), 2865-2882, 2018
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive …
K Szczepańska, S Podlewska, M Dichiara, D Gentile, V Patamia, N Rosier, ...
ACS chemical neuroscience 13 (1), 1-15, 2021
A dynamic, split-luciferase-based mini-G protein sensor to functionally characterize ligands at all four histamine receptor subtypes
C Höring, U Seibel, K Tropmann, L Grätz, D Mönnich, S Pitzl, G Bernhardt, ...
International Journal of Molecular Sciences 21 (22), 8440, 2020
Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists
H Schihada, X Ma, U Zabel, HF Vischer, G Schulte, R Leurs, S Pockes, ...
ACS sensors 5 (6), 1734-1742, 2020
A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors
L Forster, L Grätz, D Mönnich, G Bernhardt, S Pockes
International Journal of Molecular Sciences 21 (17), 6103, 2020
NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells
L Grätz, K Tropmann, M Bresinsky, C Müller, G Bernhardt, S Pockes
Scientific Reports 10 (1), 13288, 2020
Cardiac effects of novel histamine H2 receptor agonists
U Gergs, ML Büxel, M Bresinsky, U Kirchhefer, C Fehse, C Höring, ...
Journal of Pharmacology and Experimental Therapeutics 379 (3), 223-234, 2021
Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent
K Szczepańska, S Pockes, S Podlewska, C Höring, K Mika, G Latacz, ...
European Journal of Medicinal Chemistry 213, 113041, 2021
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R
S Biselli, M Bresinsky, K Tropmann, L Forster, C Honisch, A Buschauer, ...
European Journal of Medicinal Chemistry 214, 113190, 2021
Structure-based design and biological evaluation of novel caspase-2 inhibitors based on the peptide AcVDVAD-CHO and the caspase-2-mediated tau cleavage sequence YKPVD314
M Bresinsky, JM Strasser, B Vallaster, P Liu, WM McCue, J Fuller, ...
ACS Pharmacology & Translational Science 5 (1), 20-40, 2022
Light‐Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum
K Rustler, S Pockes, B König
ChemMedChem 14 (6), 636-644, 2019
Abolishing Dopamine D2long/D3 Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H2 Receptor Agonists
K Tropmann, M Bresinsky, L Forster, D Mönnich, A Buschauer, ...
Journal of Medicinal Chemistry 64 (12), 8684-8709, 2021
Discovery of a G Protein-Biased Radioligand for the Histamine H2 Receptor with Reversible Binding Properties
K Tropmann, C Höring, N Plank, S Pockes
Journal of Medicinal Chemistry 63 (21), 13090-13102, 2020
Caspase-2 inhibitor blocks tau truncation and restores excitatory neurotransmission in neurons modeling FTDP-17 tauopathy
G Singh, P Liu, KR Yao, JM Strasser, C Hlynialuk, K Leinonen-Wright, ...
ACS chemical neuroscience 13 (10), 1549-1557, 2022
Highly potent, stable, and selective dimeric hetarylpropylguanidine-type histamine H2 receptor agonists. ACS Omega. 3 (3): 2865–2882
S Pockes, D Wifling, M Keller, A Buschauer, S Elz
Effects of ergotamine, ergometrine and LSD on mouse and human atrial preparations
H Jacob, P Braekow, C Höhm, U Gergs, B Hofmann, U Kirchhefer, ...
Naunyn-Schmiedeberg’s Arch. Pharmacol, 2023
Investigating the ligand agonism and antagonism at the D2long receptor by dynamic mass redistribution
L Forster, S Pockes
Scientific Reports 12 (1), 9637, 2022
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