David Sims
David Sims
Verified email at imm.ox.ac.uk
TitleCited byYear
Sequencing depth and coverage: key considerations in genomic analyses
D Sims, I Sudbery, NE Ilott, A Heger, CP Ponting
Nature Reviews Genetics 15 (2), 121-132, 2014
8712014
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ...
elife 1, e00205, 2012
2862012
Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes
NE Ilott, JA Heward, B Roux, E Tsitsiou, PS Fenwick, L Lenzi, I Goodhead, ...
Nature communications 5, 3979, 2014
1962014
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
I Bajrami, JR Frankum, A Konde, RE Miller, FL Rehman, R Brough, ...
Cancer research 74 (1), 287-297, 2014
1572014
Functional viability profiles of breast cancer
R Brough, JR Frankum, D Sims, A Mackay, AM Mendes-Pereira, I Bajrami, ...
Cancer discovery 1 (3), 260-273, 2011
1362011
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
HK Long, D Sims, A Heger, NP Blackledge, C Kutter, ML Wright, ...
Elife 2, e00348, 2013
1312013
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
D Sims, AM Mendes-Pereira, J Frankum, D Burgess, MA Cerone, ...
Genome biology 12 (10), R104, 2011
1182011
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
AM Mendes-Pereira, D Sims, T Dexter, K Fenwick, I Assiotis, I Kozarewa, ...
Proceedings of the National Academy of Sciences 109 (8), 2730-2735, 2012
1152012
Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy
P Rajan, IM Sudbery, MEM Villasevil, E Mui, J Fleming, M Davis, I Ahmad, ...
European urology 66 (1), 32-39, 2014
832014
Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair–deficient cancers
SA Martin, M Hewish, D Sims, CJ Lord, A Ashworth
Cancer research 71 (5), 1836-1848, 2011
822011
De novo point mutations in patients diagnosed with ataxic cerebral palsy
R Parolin Schnekenberg, EM Perkins, JW Miller, WIL Davies, ...
Brain 138 (7), 1817-1832, 2015
732015
SPG7 mutations are a common cause of undiagnosed ataxia
G Pfeffer, A Pyle, H Griffin, J Miller, V Wilson, L Turnbull, K Fawcett, ...
Neurology 84 (11), 1174-1176, 2015
692015
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
JL Rohn, D Sims, T Liu, M Fedorova, F Schöck, J Dopie, MK Vartiainen, ...
J Cell Biol 194 (5), 789-805, 2011
572011
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology
T Liu, D Sims, B Baum
Genome biology 10 (3), R26, 2009
552009
An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor
N Murugaesu, M Iravani, A Van Weverwijk, A Ivetic, DA Johnson, ...
Cancer discovery 4 (3), 304-317, 2014
512014
FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets
D Sims, B Bursteinas, Q Gao, M Zvelebil, B Baum
Nucleic acids research 34 (suppl_1), D479-D483, 2006
482006
Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor
E Iorns, TM Ward, S Dean, A Jegg, D Thomas, N Murugaesu, D Sims, ...
Breast cancer research and treatment 135 (1), 79-91, 2012
422012
PDGF/VEGF signaling controls cell size in Drosophila
D Sims, P Duchek, B Baum
Genome biology 10 (2), R20, 2009
402009
CGAT: computational genomics analysis toolkit
D Sims, NE Ilott, SN Sansom, IM Sudbery, JS Johnson, KA Fawcett, ...
Bioinformatics 30 (9), 1290-1291, 2014
392014
ROCK: a breast cancer functional genomics resource
D Sims, B Bursteinas, Q Gao, E Jain, A MacKay, C Mitsopoulos, ...
Breast cancer research and treatment 124 (2), 567-572, 2010
342010
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Articles 1–20