|Sequencing depth and coverage: key considerations in genomic analyses|
D Sims, I Sudbery, NE Ilott, A Heger, CP Ponting
Nature Reviews Genetics 15 (2), 121-132, 2014
|KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands|
AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ...
elife 1, e00205, 2012
|Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes|
NE Ilott, JA Heward, B Roux, E Tsitsiou, PS Fenwick, L Lenzi, I Goodhead, ...
Nature communications 5 (1), 1-14, 2014
|Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity|
I Bajrami, JR Frankum, A Konde, RE Miller, FL Rehman, R Brough, ...
Cancer research 74 (1), 287-297, 2014
|Functional viability profiles of breast cancer|
R Brough, JR Frankum, D Sims, A Mackay, AM Mendes-Pereira, I Bajrami, ...
Cancer discovery 1 (3), 260-273, 2011
|Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates|
HK Long, D Sims, A Heger, NP Blackledge, C Kutter, ML Wright, ...
elife 2, e00348, 2013
|High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing|
D Sims, AM Mendes-Pereira, J Frankum, D Burgess, MA Cerone, ...
Genome biology 12 (10), 1-13, 2011
|Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen|
AM Mendes-Pereira, D Sims, T Dexter, K Fenwick, I Assiotis, I Kozarewa, ...
Proceedings of the National Academy of Sciences 109 (8), 2730-2735, 2012
|Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy|
P Rajan, IM Sudbery, MEM Villasevil, E Mui, J Fleming, M Davis, I Ahmad, ...
European urology 66 (1), 32-39, 2014
|De novo point mutations in patients diagnosed with ataxic cerebral palsy|
R Parolin Schnekenberg, EM Perkins, JW Miller, WIL Davies, ...
Brain 138 (7), 1817-1832, 2015
|Parallel high-throughput RNA interference screens identify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair–deficient cancers|
SA Martin, M Hewish, D Sims, CJ Lord, A Ashworth
Cancer research 71 (5), 1836-1848, 2011
|SPG7 mutations are a common cause of undiagnosed ataxia|
G Pfeffer, A Pyle, H Griffin, J Miller, V Wilson, L Turnbull, K Fawcett, ...
Neurology 84 (11), 1174-1176, 2015
|Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype|
JL Rohn, D Sims, T Liu, M Fedorova, F Schöck, J Dopie, MK Vartiainen, ...
Journal of Cell Biology 194 (5), 789-805, 2011
|An in vivo functional screen identifies ST6GalNAc2 sialyltransferase as a breast cancer metastasis suppressor|
N Murugaesu, M Iravani, A Van Weverwijk, A Ivetic, DA Johnson, ...
Cancer discovery 4 (3), 304-317, 2014
|Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology|
T Liu, D Sims, B Baum
Genome biology 10 (3), R26, 2009
|Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor|
E Iorns, TM Ward, S Dean, A Jegg, D Thomas, N Murugaesu, D Sims, ...
Breast cancer research and treatment 135 (1), 79-91, 2012
|FLIGHT: database and tools for the integration and cross-correlation of large-scale RNAi phenotypic datasets|
D Sims, B Bursteinas, Q Gao, M Zvelebil, B Baum
Nucleic acids research 34 (suppl_1), D479-D483, 2006
|CGAT: computational genomics analysis toolkit|
D Sims, NE Ilott, SN Sansom, IM Sudbery, JS Johnson, KA Fawcett, ...
Bioinformatics 30 (9), 1290-1291, 2014
|Tuning the transcriptional response to hypoxia by inhibiting hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases|
MC Chan, NE Ilott, J Schödel, D Sims, A Tumber, K Lippl, DR Mole, ...
Journal of Biological Chemistry 291 (39), 20661-20673, 2016
|Multipotent basal stem cells, maintained in localized proximal niches, support directed long-ranging epithelial flows in human prostates|
M Moad, E Hannezo, SJ Buczacki, L Wilson, A El-Sherif, D Sims, ...
Cell reports 20 (7), 1609-1622, 2017