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| Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1 MC Maiuri, G Le Toumelin, A Criollo, JC Rain, F Gautier, P Juin, ... The EMBO journal 26 (10), 2527-2539, 2007 | 1184 | 2007 |
| Apoptosis induced by anticancer drugs JA Hickman Cancer and Metastasis Reviews 11 (2), 121-139, 1992 | 1156 | 1992 |
| The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice AJ Merritt, CS Potten, CJ Kemp, JA Hickman, A Balmain, DP Lane, ... Cancer research 54 (3), 614-617, 1994 | 700 | 1994 |
| Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis GJ Griffiths, L Dubrez, CP Morgan, NA Jones, J Whitehouse, BM Corfe, ... The Journal of cell biology 144 (5), 903-914, 1999 | 575 | 1999 |
| The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ... Nature 538 (7626), 477-482, 2016 | 565 | 2016 |
| Drug-target interactions: only the first step in the commitment to a programmed cell death? C Dive, JA Hickman British journal of cancer 64 (1), 192-196, 1991 | 536 | 1991 |
| Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one (CCRG 81045; M & B 39831), a novel drug with potential … MFG Stevens, JA Hickman, SP Langdon, D Chubb, L Vickers, R Stone, ... Cancer research 47 (22), 5846-5852, 1987 | 463 | 1987 |
| BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-XL MC Maiuri, A Criollo, E Tasdemir, JM Vicencio, N Tajeddine, JA Hickman, ... Autophagy 3 (4), 374-376, 2007 | 458 | 2007 |
| Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia AJ Merritt, CS Potten, AJ Watson, DY Loh, K Nakayama, JA Hickman Journal of cell science 108 (6), 2261-2271, 1995 | 355 | 1995 |
| Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax: Bcl-2 ratio CM Chresta, JRW Masters, JA Hickman Cancer research 56 (8), 1834-1841, 1996 | 326 | 1996 |
| Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium S Pullan, J Wilson, A Metcalfe, GM Edwards, N Goberdhan, J Tilly, ... Journal of cell science 109 (3), 631-642, 1996 | 322 | 1996 |
| bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways TC Fisher, AE Milner, CD Gregory, AL Jackman, GW Aherne, JA Hartley, ... Cancer Research 53 (14), 3321-3326, 1993 | 309 | 1993 |
| Limits to personalized cancer medicine IF Tannock, JA Hickman N Engl J Med 375 (13), 1289-1294, 2016 | 298 | 2016 |
| Apoptosis in small intestinal epithelia from p53-null mice: evidence for a delayed, p53-indepdendent G2/M-associated cell death after γ-irradiation AJ Merritt, TD Allen, CS Potten, JA Hickman Oncogene 14 (23), 2759-2766, 1997 | 265 | 1997 |
| Apoptosis and cancer chemotherapy G Makin, JA Hickman Cell and tissue research 301 (1), 143-152, 2000 | 256 | 2000 |
| Three‐dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo JA Hickman, R Graeser, R de Hoogt, S Vidic, C Brito, M Gutekunst, ... Biotechnology journal 9 (9), 1115-1128, 2014 | 241 | 2014 |
| Antitumour imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl) imidazo [5, 1-d]-1, 2, 3, 5-tetrazin-4 (3H)-one, a novel broad-spectrum antitumor agent MFG Stevens, JA Hickman, R Stone, NW Gibson, GU Baig, E Lunt, ... Journal of medicinal chemistry 27 (2), 196-201, 1984 | 241 | 1984 |
| Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells B Marty, V Maire, E Gravier, G Rigaill, A Vincent-Salomon, M Kappler, ... Breast Cancer Research 10 (6), 1-15, 2008 | 240 | 2008 |
| Apoptosis and chemotherapy resistance JA Hickman European Journal of Cancer 32 (6), 921-926, 1996 | 234 | 1996 |
