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Federico Focher
Federico Focher
Director of Research, IGM-CNR, Pavia, Italy
Verified email at igm.cnr.it - Homepage
Title
Cited by
Cited by
Year
L-Thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth
S Spadari, G Maga, F Focher, G Ciarrocchi, R Manservigi, F Arcamone, ...
Journal of medicinal chemistry 35 (22), 4214-4220, 1992
1501992
The specific binding of nuclear protein (s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C
A Verri, P Mazzarello, G Biamonti, S Spadari, F Focher
Nucleic acids research 18 (19), 5775-5780, 1990
971990
Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy
F Focher, S Spadari
Current cancer drug targets 1 (2), 141-153, 2001
912001
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development
F Focher, P Mazzarello, A Verri, U Hübscher, S Spadari
Mutation Research/DNAging 237 (2), 65-73, 1990
771990
N2-Phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymiding kinase
F Focher, C Hildebrand, S Freese, G Ciarrocchi, T Noonan, S Sangalli, ...
Journal of medicinal chemistry 31 (8), 1496-1500, 1988
751988
Calf thymus DNA polymerase δ independent of proliferating cell nuclear antigen (PCNA)
F Focher, M Gassmann, P Hafkmeyer, E Ferrari, S Spadari, U Hübscher
Nucleic acids research 17 (5), 1805-1821, 1989
701989
DNA ligase I gene expression during differentiation and cell proliferation
A Montecucco, G Biamonti, E Savini, F Focher, S Spadari, G Ciarrocchi
Nucleic acids research 20 (23), 6209-6214, 1992
661992
Lack of enantiospecificity of human 2′-deoxycytidine kinase: relevance for the activation of β-L-deoxycytidine analogs as antineoplastic and antiviral agents
A Verri, F Focher, G Priori, G Gosselin, JL Imbach, M Capobianco, ...
Molecular Pharmacology 51 (1), 132-138, 1997
641997
DNA repair mechanisms in neurological diseases: facts and hypotheses
P Mazzarello, M Poloni, S Spadari, F Focher
Journal of the neurological sciences 112 (1-2), 4-14, 1992
611992
Stereospecificity of human DNA polymerases α, β, γ, § and ɛ, HIV-reverse transcriptase, HSV-DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase …
F Focher, G Maga, A Bendiscioli, M Capobianco, F Colonna, A Garbesi, ...
Nucleic acids research 23 (15), 2840-2847, 1995
60*1995
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases
C Hildebrand, D Sandoli, F Focher, J Gambino, G Ciarrocchi, S Spadari, ...
Journal of medicinal chemistry 33 (1), 203-206, 1990
601990
Calf thymus DNA polymerase δ: purification, biochemical and functional properties of the enzyme after its separation from DNA polymerase α, a DNA dependent ATPase and …
F Focher, S Spadari, B Ginelli, M Hottiger, M Gassmann, U Hübscher
Nucleic acids research 16 (14), 6279-6295, 1988
601988
Control of cell division by aphidicolin without adverse effects upon resting cells.
S Spadari, F Focher, F Sala, G Ciarrocchi, G Koch, A Falaschi, ...
Arzneimittel-forschung 35 (7), 1108-1116, 1985
571985
Inhibitor analysis of calf thymus DNA polymerases α, δ and ϵ
GE Wright, U Hübscher, NN Khan, F Focher, A Verri
FEBS letters 341 (1), 128-130, 1994
541994
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure− activity relationships and antiherpetic activity in vivo
A Manikowski, A Verri, A Lossani, BM Gebhardt, J Gambino, F Focher, ...
Journal of medicinal chemistry 48 (11), 3919-3929, 2005
532005
Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives
F Focher, A Verri, S Spadari, R Manservigi, J Gambino, GE Wright
Biochemical Journal 292 (3), 883-889, 1993
531993
DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs.
S Spadari, G Pedrali-Noy, F Focher, A Montecucco, T Bordoni, C Geroni, ...
Anticancer research 6 (5), 935-940, 1986
531986
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases
H Xu, G Maga, F Focher, ER Smith, S Spadari, J Gambino, GE Wright
Journal of medicinal chemistry 38 (1), 49-57, 1995
521995
Uracil in Oris of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral …
F Focher, A Verri, S Verzeletti, P Mazzarello, S Spadari
Chromosoma 102, S67-S71, 1992
511992
Do DNA polymerases δ and α act coordinately as leading and lagging strand replicases?
F Focher, E Ferrari, S Spadari, U Hübscher
FEBS letters 229 (1), 6-10, 1988
511988
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