Structure of TPR domain–peptide complexes: critical elements in the assembly of the Hsp70–Hsp90 multichaperone machine C Scheufler, A Brinker, G Bourenkov, S Pegoraro, L Moroder, H Bartunik, ... Cell 101 (2), 199-210, 2000 | 1513 | 2000 |
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors H Sondermann, C Scheufler, C Schneider, J Hohfeld, FU Hartl, I Moarefi Science 291 (5508), 1553-1557, 2001 | 567 | 2001 |
Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution C Scheufler, W Sebald, M Hülsmeyer Journal of molecular biology 287 (1), 103-115, 1999 | 502 | 1999 |
Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins R Siegert, MR Leroux, C Scheufler, FU Hartl, I Moarefi Cell 103 (4), 621-632, 2000 | 370 | 2000 |
Ligand discrimination by TPR domains: Relevance and selectivity of EEVD-recognition in Hsp70· Hop· Hsp90 complexes A Brinker, C Scheufler, F Von Der Mülbe, B Fleckenstein, C Herrmann, ... Journal of Biological Chemistry 277 (22), 19265-19275, 2002 | 294 | 2002 |
Modulation of activation-loop phosphorylation by JAK inhibitors is binding mode dependent R Andraos, Z Qian, D Bonenfant, J Rubert, E Vangrevelinghe, C Scheufler, ... Cancer discovery 2 (6), 512-523, 2012 | 143 | 2012 |
Discovery of LOU064 (Remibrutinib), a potent and highly selective covalent inhibitor of Bruton’s tyrosine kinase D Angst, F Gessier, P Janser, A Vulpetti, R Wälchli, C Beerli, ... Journal of Medicinal Chemistry 63 (10), 5102-5118, 2020 | 128 | 2020 |
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy F Morvan, JM Rondeau, C Zou, G Minetti, C Scheufler, M Scharenberg, ... Proceedings of the National Academy of Sciences 114 (47), 12448-12453, 2017 | 122 | 2017 |
Discovery of novel Dot1L inhibitors through a structure-based fragmentation approach C Chen, H Zhu, F Stauffer, G Caravatti, S Vollmer, R Machauer, P Holzer, ... ACS Medicinal Chemistry Letters 7 (8), 735-740, 2016 | 58 | 2016 |
Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity A Schlapbach, R Feifel, S Hawtin, R Heng, G Koch, H Moebitz, L Revesz, ... Bioorganic & medicinal chemistry letters 18 (23), 6142-6146, 2008 | 58 | 2008 |
Discovery of potent, selective, and structurally novel Dot1L inhibitors by a fragment linking approach H Möbitz, R Machauer, P Holzer, A Vaupel, F Stauffer, C Ragot, ... ACS medicinal chemistry letters 8 (3), 338-343, 2017 | 54 | 2017 |
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy J Velcicky, R Feifel, S Hawtin, R Heng, C Huppertz, G Koch, M Kroemer, ... Bioorganic & medicinal chemistry letters 20 (3), 1293-1297, 2010 | 51 | 2010 |
Optimization of a fragment-based screening hit toward potent DOT1L inhibitors interacting in an induced binding pocket C Scheufler, H Möbitz, C Gaul, C Ragot, C Be, C Fernández, KS Beyer, ... ACS Medicinal Chemistry Letters 7 (8), 730-734, 2016 | 49 | 2016 |
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II L Revesz, A Schlapbach, R Aichholz, J Dawson, R Feifel, S Hawtin, ... Bioorganic & medicinal chemistry letters 20 (15), 4719-4723, 2010 | 40 | 2010 |
Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies PS Kutchukian, AM Wassermann, MK Lindvall, SK Wright, J Ottl, J Jacob, ... Journal of biomolecular screening 20 (5), 588-596, 2015 | 36 | 2015 |
Applications of biophysics in high-throughput screening hit validation CC Genick, D Barlier, D Monna, R Brunner, C Bé, C Scheufler, J Ottl Journal of Biomolecular Screening 19 (5), 707-714, 2014 | 30 | 2014 |
Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies Y Huang, M Sendzik, J Zhang, Z Gao, Y Sun, L Wang, J Gu, K Zhao, Z Yu, ... Journal of medicinal chemistry 65 (7), 5317-5333, 2022 | 29 | 2022 |
Crystal structures of two cyanobacterial response regulators in apo-and phosphorylated form reveal a novel dimerization motif of phytochrome-associated response regulators C Benda, C Scheufler, NT de Marsac, W Gärtner Biophysical journal 87 (1), 476-487, 2004 | 28 | 2004 |
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I L Revesz, A Schlapbach, R Aichholz, R Feifel, S Hawtin, R Heng, ... Bioorganic & medicinal chemistry letters 20 (15), 4715-4718, 2010 | 27 | 2010 |
Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay Y Lin, H Fan, M Frederiksen, K Zhao, L Jiang, Z Wang, S Zhou, W Guo, ... Analytical biochemistry 423 (1), 171-177, 2012 | 25 | 2012 |