| Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer R Di Micco, G Sulli, M Dobreva, M Liontos, OA Botrugno, G Gargiulo, ... Nature cell biology 13 (3), 292-302, 2011 | 383 | 2011 |
| Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis M Molinari, C Mercurio, J Dominguez, F Goubin, GF Draetta EMBO reports 1 (1), 71-79, 2000 | 264 | 2000 |
| Histone deacetylases and epigenetic therapies of hematological malignancies C Mercurio, S Minucci, PG Pelicci Pharmacological research 62 (1), 18-34, 2010 | 147 | 2010 |
| 3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 2. Lead optimization P Pevarello, MG Brasca, P Orsini, G Traquandi, A Longo, M Nesi, F Orzi, ... Journal of medicinal chemistry 48 (8), 2944-2956, 2005 | 140 | 2005 |
| Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers AJ Deans, KK Khanna, CJ McNees, C Mercurio, J Heierhorst, ... Cancer research 66 (16), 8219-8226, 2006 | 133 | 2006 |
| Pathology tissue–chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples M Fanelli, S Amatori, I Barozzi, M Soncini, R Dal Zuffo, G Bucci, M Capra, ... Proceedings of the National Academy of Sciences 107 (50), 21535-21540, 2010 | 116 | 2010 |
| Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next F Thaler, C Mercurio ChemMedChem 9 (3), 523-536, 2014 | 109 | 2014 |
| Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors G La Regina, R Bai, WM Rensen, E Di Cesare, A Coluccia, F Piscitelli, ... Journal of medicinal chemistry 56 (1), 123-149, 2013 | 107 | 2013 |
| Drf1, a novel regulatory subunit for human Cdc7 kinase A Montagnoli, R Bosotti, F Villa, M Rialland, D Brotherton, C Mercurio, ... The EMBO Journal, 2002 | 106 | 2002 |
| Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors M Varasi, F Thaler, A Abate, C Bigogno, R Boggio, G Carenzi, ... Journal of Medicinal Chemistry 54 (8), 3051-3064, 2011 | 99 | 2011 |
| Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability G La Regina, R Bai, W Rensen, A Coluccia, F Piscitelli, V Gatti, ... Journal of medicinal chemistry 54 (24), 8394-8406, 2011 | 95 | 2011 |
| New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer G La Regina, R Bai, A Coluccia, V Famiglini, S Pelliccia, S Passacantilli, ... Journal of medicinal chemistry 57 (15), 6531-6552, 2014 | 84 | 2014 |
| Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent P Vianello, OA Botrugno, A Cappa, R Dal Zuffo, P Dessanti, A Mai, ... Journal of Medicinal Chemistry 59 (4), 1501-1517, 2016 | 80 | 2016 |
| Optimization of 6, 6-dimethyl pyrrolo [3, 4-c] pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing MG Brasca, C Albanese, R Alzani, R Amici, N Avanzi, D Ballinari, ... Bioorganic & medicinal chemistry 18 (5), 1844-1853, 2010 | 76 | 2010 |
| Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and … L Sartori, C Mercurio, F Amigoni, A Cappa, G Faga, R Fattori, E Legnaghi, ... Journal of Medicinal Chemistry 60 (5), 1673-1692, 2017 | 74 | 2017 |
| Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner M Elgendy, M Ciro, AK Abdel-Aziz, G Belmonte, RD Zuffo, C Mercurio, ... Nature communications 5 (1), 5637, 2014 | 74 | 2014 |
| Fragment‐based identification of Hsp90 inhibitors JJ Barker, O Barker, R Boggio, V Chauhan, RKY Cheng, V Corden, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (6), 963-966, 2009 | 71 | 2009 |
| Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and … P Vianello, L Sartori, F Amigoni, A Cappa, G Faga, R Fattori, E Legnaghi, ... Journal of Medicinal Chemistry 60 (5), 1693-1715, 2017 | 70 | 2017 |
| 3-Amino-1, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazoles: A new class of CDK2 inhibitors P Pevarello, D Fancelli, A Vulpetti, R Amici, M Villa, V Pittalà, P Vianello, ... Bioorganic & medicinal chemistry letters 16 (4), 1084-1090, 2006 | 69 | 2006 |
| Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A P Vianello, OA Botrugno, A Cappa, G Ciossani, P Dessanti, A Mai, ... European journal of medicinal chemistry 86, 352-363, 2014 | 68 | 2014 |
Saverio MinucciEuropean Institute of Oncology and University of MilanVerified email at ieo.it
