| Glucose feeds the TCA cycle via circulating lactate S Hui, JM Ghergurovich, RJ Morscher, C Jang, X Teng, W Lu, LA Esparza, ... Nature 551 (7678), 115-118, 2017 | 1304 | 2017 |
| Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway GS Ducker, L Chen, RJ Morscher, JM Ghergurovich, M Esposito, X Teng, ... Cell metabolism 23 (6), 1140-1153, 2016 | 400 | 2016 |
| Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation N Ron-Harel, D Santos, JM Ghergurovich, PT Sage, A Reddy, SB Lovitch, ... Cell metabolism 24 (1), 104-117, 2016 | 342 | 2016 |
| As extracellular glutamine levels decline, asparagine becomes an essential amino acid NN Pavlova, S Hui, JM Ghergurovich, J Fan, AM Intlekofer, RM White, ... Cell metabolism 27 (2), 428-438. e5, 2018 | 276 | 2018 |
| Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma GS Ducker, JM Ghergurovich, N Mainolfi, V Suri, SK Jeong, ... Proceedings of the National Academy of Sciences 114 (43), 11404-11409, 2017 | 226 | 2017 |
| Serine catabolism feeds NADH when respiration is impaired L Yang, JCG Canaveras, Z Chen, L Wang, L Liang, C Jang, JA Mayr, ... Cell metabolism 31 (4), 809-821. e6, 2020 | 138 | 2020 |
| T cell activation depends on extracellular alanine N Ron-Harel, JM Ghergurovich, G Notarangelo, MW LaFleur, ... Cell reports 28 (12), 3011-3021. e4, 2019 | 132 | 2019 |
| A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway JM Ghergurovich, JC García-Cañaveras, J Wang, E Schmidt, Z Zhang, ... Nature chemical biology 16 (7), 731-739, 2020 | 116 | 2020 |
| Defective respiration and one-carbon metabolism contribute to impaired naive T cell activation in aged mice N Ron-Harel, G Notarangelo, JM Ghergurovich, JA Paulo, PT Sage, ... Proceedings of the National Academy of Sciences 115 (52), 13347-13352, 2018 | 105 | 2018 |
| SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia JC García-Cañaveras, O Lancho, GS Ducker, JM Ghergurovich, X Xu, ... Leukemia 35 (2), 377-388, 2021 | 81 | 2021 |
| Upregulation of antioxidant capacity and nucleotide precursor availability suffices for oncogenic transformation Y Zhang, Y Xu, W Lu, JM Ghergurovich, L Guo, IA Blair, JD Rabinowitz, ... Cell metabolism 33 (1), 94-109. e8, 2021 | 45 | 2021 |
| Local production of lactate, ribose phosphate, and amino acids by human triple-negative breast cancer JM Ghergurovich, JD Lang, MK Levin, N Briones, SJ Facista, C Mueller, ... Med 2 (6), 736-754. e6, 2021 | 40 | 2021 |
| Glucose-6-phosphate dehydrogenase is not essential for K-ras–driven tumor growth or metastasis JM Ghergurovich, M Esposito, Z Chen, JZ Wang, V Bhatt, T Lan, E White, ... Cancer research 80 (18), 3820-3829, 2020 | 38 | 2020 |
| Methionine synthase supports tumour tetrahydrofolate pools JM Ghergurovich, X Xu, JZ Wang, L Yang, RP Ryseck, L Wang, ... Nature metabolism 3 (11), 1512-1520, 2021 | 30 | 2021 |
| Triazolones as fatty acid synthase inhibitors ND Adams, CJ Aquino, AM Chaudhari, JM Ghergurovich, TJ Kiesow, ... | 9 | 2011 |
| SHMT inhibitors JD Rabinowitz, H Kim, GS Ducker, JM Ghergurovich US Patent 10,646,475, 2020 | 7 | 2020 |
| Abstract CT165: Phase II open label trial of minnelide™ in patients with chemotherapy refractory metastatic pancreatic cancer D Propper, H Han, DV Hoff, E Borazanci, T Reya, J Ghergurovich, ... Cancer Research 79 (13_Supplement), CT165-CT165, 2019 | 6 | 2019 |
| SHMT inhibitors JD Rabinowitz, H Kim, GS Ducker, JM Ghergurovich US Patent 10,077,273, 2018 | 6 | 2018 |
| Prolyl Hydroxylase Inhibitors MJ Schulz, Y Wang, JM Ghergurovich US Patent WO2010059555 A 1, 27, 2010 | 5 | 2010 |
| SHMT inhibitors JD Rabinowitz, H Kim, GS Ducker, JM Ghergurovich US Patent 10,584,132, 2020 | 4 | 2020 |
Gregory S DuckerUniversity of UtahVerified email at biochem.utah.edu
