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Shenshen Hu
Shenshen Hu
Corvus Pharma
Verified email at corvuspharma.com - Homepage
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Year
Asymmetric supramolecular primary amine catalysis in aqueous buffer: connections of selective recognition and asymmetric catalysis
S Hu, J Li, J Xiang, J Pan, S Luo, JP Cheng
Journal of the American Chemical Society 132 (20), 7216-7228, 2010
1232010
Extremely elevated room-temperature kinetic isotope effects quantify the critical role of barrier width in enzymatic C–H activation
S Hu, SC Sharma, AD Scouras, AV Soudackov, CAM Carr, ...
Journal of the American Chemical Society 136 (23), 8157-8160, 2014
942014
Chiral Amine Thiourea-Promoted Enantioselective Michael Addition Reactions of 3-Substituted Benzofuran-2(3H)-ones to Maleimides
X Li, S Hu, Z Xi, L Zhang, S Luo, JP Cheng
The Journal of Organic Chemistry 75 (24), 8697-8700, 2010
752010
Asymmetric binary-acid catalysis with InBr3 in the inverse-electron-demanding hetero-Diels-Alder reaction of mono-and bis-substituted cyclopentadienes: remote fluoro-effect on …
J Lv, L Zhang, S Hu, JP Cheng, S Luo
Chemistry (Weinheim an der Bergstrasse, Germany) 18 (3), 799-803, 2011
732011
Origins of enzyme catalysis: Experimental findings for C–H activation, new models, and their relevance to prevailing theoretical constructs
JP Klinman, AR Offenbacher, S Hu
Journal of the American Chemical Society 139 (51), 18409-18427, 2017
632017
Hydrogen–deuterium exchange of lipoxygenase uncovers a relationship between distal, solvent exposed protein motions and the thermal activation barrier for catalytic proton …
AR Offenbacher, S Hu, EM Poss, CAM Carr, AD Scouras, DM Prigozhin, ...
ACS central science 3 (6), 570-579, 2017
592017
Enhanced rigidification within a double mutant of soybean lipoxygenase provides experimental support for vibronically nonadiabatic proton-coupled electron transfer models
S Hu, AV Soudackov, S Hammes-Schiffer, JP Klinman
ACS catalysis 7 (5), 3569-3574, 2017
552017
Chiral Primary Amine Catalyzed Asymmetric Direct Cross‐Aldol Reaction of Acetaldehyde
S Hu, L Zhang, J Li, S Luo, JP Cheng
European Journal of Organic Chemistry 2011 (18), 3347-3352, 2011
382011
Chiral amine–polyoxometalate hybrids as recoverable asymmetric enamine catalysts under neat and aqueous conditions
J Li, S Hu, S Luo, JP Cheng
European Journal of Organic Chemistry 2009 (1), 132-140, 2009
342009
Biophysical characterization of a disabled double mutant of soybean lipoxygenase: the “undoing” of precise substrate positioning relative to metal cofactor and an identified …
S Hu, AR Offenbacher, EM Thompson, CL Gee, J Wilcoxen, CAM Carr, ...
Journal of the American Chemical Society 141 (4), 1555-1567, 2019
242019
AM; Hammes-Schiffer, S.; Alber, T.; Klinman, JP
S Hu, SC Sharma, AD Scouras, AV Soudackov, C Carr
J. Am. Chem. Soc 136, 8157-8160, 2014
182014
Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C− H Activation by Soybean Lipoxygenase‐1
S Hu, J Cattin‐Ortolá, JW Munos, JP Klinman
Angewandte Chemie International Edition 55 (32), 9361-9364, 2016
172016
Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase
JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ...
Proceedings of the National Academy of Sciences 120 (10), e2211630120, 2023
122023
Characterization and Phase 1 trial of a B cell activating anti-CD73 antibody for the immunotherapy of COVID-19
SB Willingham, G Criner, C Hill, S Hu, JA Rudnick, B Daine-Matsuoka, ...
MedRxiv, 2020.09. 10.20191486, 2020
82020
Comparative kinetic isotope effects on first-and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network
S Hu, AR Offenbacher, ED Lu, JP Klinman
Journal of Biological Chemistry 294 (48), 18069-18076, 2019
82019
Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer
RA Miller, JJ Luke, S Hu, S Mahabhashyam, WB Jones, T Marron, ...
Journal for Immunotherapy of Cancer 10 (12), 2022
62022
Temporal and spatial resolution of a protein quake that activates hydrogen tunneling in soybean lipoxygenase
JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ...
bioRxiv, 2022.03. 31.486235, 2022
42022
Clinical results with a B cell activating Anti-CD73 antibody for the immunotherapy of COVID-19
RA Miller, P Guru, P Bauer, J Robles, C Tomaszewski, JS Overcash, ...
MedRxiv, 2021.09. 13.21263406, 2021
42021
701 Activating CD73 on B cells as a target for immunotherapy of COVID-19 and viral associated cancers: clinical activity in human papilloma virus positive (HPV) head and neck …
J Luke, J Merchan, B Hughes, J Sosman, A Tripathi, I Puzanov, T Marron, ...
Journal for ImmunoTherapy of Cancer 9 (Suppl 2), 2021
32021
325 Immunotherapy with B cell activating antibody CPI-006 in patients (pts) with mild to moderate COVID-19 stimulates anti-SARS-CoV-2 antibody response, memory B cells and …
G Criner, M Mobasher, C Hill, S Hu, S Mahabhashyam, J Brody, T Marron, ...
Journal for ImmunoTherapy of Cancer 8 (Suppl 3), 2020
12020
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