| Depletion of microglia and inhibition of exosome synthesis halt tau propagation H Asai, S Ikezu, S Tsunoda, M Medalla, J Luebke, T Haydar, B Wolozin, ... Nature neuroscience 18 (11), 1584-1593, 2015 | 1422 | 2015 |
| Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons Z Ruan, D Pathak, S Venkatesan Kalavai, A Yoshii-Kitahara, S Muraoka, ... Brain 144 (1), 288-309, 2021 | 159 | 2021 |
| Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model K Clayton, JC Delpech, S Herron, N Iwahara, M Ericsson, T Saito, ... Molecular neurodegeneration 16, 1-16, 2021 | 119 | 2021 |
| Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues S Muraoka, AM DeLeo, MK Sethi, K Yukawa‐Takamatsu, Z Yang, J Ko, ... Alzheimer's & Dementia 16 (6), 896-907, 2020 | 114 | 2020 |
| miR-155 is essential for inflammation-induced hippocampal neurogenic dysfunction ME Woodbury, RW Freilich, CJ Cheng, H Asai, S Ikezu, JD Boucher, ... Journal of Neuroscience 35 (26), 9764-9781, 2015 | 99 | 2015 |
| Proteomic profiling of extracellular vesicles derived from cerebrospinal fluid of Alzheimer’s disease patients: a pilot study S Muraoka, MP Jedrychowski, K Yanamandra, S Ikezu, SP Gygi, T Ikezu Cells 9 (9), 1959, 2020 | 94 | 2020 |
| P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice Z Ruan, JC Delpech, S Venkatesan Kalavai, AA Van Enoo, J Hu, S Ikezu, ... Molecular neurodegeneration 15, 1-14, 2020 | 76 | 2020 |
| The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease MM Varnum, T Kiyota, KL Ingraham, S Ikezu, T Ikezu Neurobiology of aging 36 (11), 2995-3007, 2015 | 74 | 2015 |
| Tau-tubulin kinase S Ikezu, T Ikezu Frontiers in molecular neuroscience 7, 33, 2014 | 74 | 2014 |
| Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities S Ikezu, H Yeh, JC Delpech, ME Woodbury, AA Van Enoo, Z Ruan, ... Molecular psychiatry 26 (6), 1808-1831, 2021 | 57 | 2021 |
| Proteomic profiling of extracellular vesicles isolated from cerebrospinal fluid of former national football league players at risk for chronic traumatic encephalopathy S Muraoka, MP Jedrychowski, H Tatebe, AM DeLeo, S Ikezu, T Tokuda, ... Frontiers in neuroscience 13, 475546, 2019 | 54 | 2019 |
| Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1 H Asai, S Ikezu, ME Woodbury, GMS Yonemoto, L Cui, T Ikezu The American journal of pathology 184 (3), 808-818, 2014 | 42 | 2014 |
| Enrichment of neurodegenerative microglia signature in brain-derived extracellular vesicles isolated from Alzheimer’s disease mouse models S Muraoka, MP Jedrychowski, N Iwahara, M Abdullah, KD Onos, ... Journal of proteome research 20 (3), 1733-1743, 2021 | 39 | 2021 |
| Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease Z Yin, S Herron, S Silveira, K Kleemann, C Gauthier, D Mallah, Y Cheng, ... Nature neuroscience 26 (7), 1196-1207, 2023 | 24 | 2023 |
| A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells MM Varnum, KA Clayton, A Yoshii-Kitahara, G Yonemoto, L Koro, S Ikezu, ... Journal of Biological Chemistry 292 (25), 10651-10663, 2017 | 22 | 2017 |
| Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models S Ikezu, KL Ingraham Dixie, L Koro, T Watanabe, K Kaibuchi, T Ikezu Acta neuropathologica communications 8, 1-16, 2020 | 21 | 2020 |
| Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice JC Delpech, D Pathak, M Varghese, SV Kalavai, EC Hays, PR Hof, ... Science translational medicine 13 (611), eabe8455, 2021 | 20 | 2021 |
| Proteomic profiling of extracellular vesicles separated from plasma of former National Football League players at risk for chronic traumatic encephalopathy S Muraoka, AM DeLeo, Z Yang, H Tatebe, K Yukawa-Takamatsu, S Ikezu, ... Aging and disease 12 (6), 1363, 2021 | 15 | 2021 |
| Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer’s-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative … H Shi, Z Yin, Y Koronyo, DT Fuchs, J Sheyn, MR Davis, JW Wilson, ... Acta Neuropathologica Communications 10 (1), 136, 2022 | 14 | 2022 |
| ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids Y You, Z Zhang, N Sultana, M Ericsson, YA Martens, M Sun, T Kanekiyo, ... Science Advances 9 (37), eadi3647, 2023 | 8 | 2023 |
