Christian  Holm
Christian Holm
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
CK Holm, SB Jensen, MR Jakobsen, N Cheshenko, KA Horan, ...
Nature immunology 13 (8), 737, 2012
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
KA Horan, K Hansen, MR Jakobsen, CK Holm, S Søby, L Unterholzner, ...
The Journal of Immunology 190 (5), 2311-2319, 2013
TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
LS Reinert, L Harder, CK Holm, MB Iversen, KA Horan, ...
The Journal of clinical investigation 122 (4), 1368-1376, 2012
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
KL Jønsson, A Laustsen, C Krapp, KA Skipper, K Thavachelvam, D Hotter, ...
Nature communications 8 (1), 1-17, 2017
Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
TK Rasmussen, T Andersen, M Hvid, ML Hetland, K Hørslev-Petersen, ...
The Journal of rheumatology 37 (10), 2014-2020, 2010
The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy
TW Kragstrup, K Otkjaer, C Holm, A Jørgensen, M Hokland, L Iversen, ...
Cytokine 41 (1), 16-23, 2008
Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes
SB Rasmussen, KA Horan, CK Holm, AJ Stranks, TC Mettenleiter, ...
The journal of immunology 187 (10), 5268-5276, 2011
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
CK Holm, SH Rahbek, HH Gad, RO Bak, MR Jakobsen, Z Jiang, ...
Nature communications 7 (1), 1-9, 2016
DNA recognition in immunity and disease
CK Holm, SR Paludan, KA Fitzgerald
Current opinion in immunology 25 (1), 13-18, 2013
Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus
TK Rasmussen, T Andersen, RO Bak, G Yiu, CM Sørensen, ...
Arthritis research & therapy 17 (1), 154, 2015
An innate antiviral pathway acting before interferons at epithelial surfaces
MB Iversen, LS Reinert, MK Thomsen, I Bagdonaite, R Nandakumar, ...
Nature immunology 17 (2), 150, 2016
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication
RK Berg, SH Rahbek, E Kofod-Olsen, CK Holm, J Melchjorsen, ...
PLoS One 9 (1), 2014
TLR3 ligand polyinosinic: polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells
CK Holm, CC Petersen, M Hvid, L Petersen, SR Paludan, B Deleuran, ...
The Journal of Immunology 183 (7), 4422-4431, 2009
Interleukin-21 mRNA expression during virus infections
C Holm, CG Nyvold, SR Plaudan, AR Thomsen, M Hokland
Cytokine 33 (1), 41-45, 2006
Increased plasma levels of IL-21 and IL-23 in spondyloarthritis are not associated with clinical and MRI findings
T Andersen, TK Rasmussen, M Hvid, CK Holm, KJNB Madsen, AG Jurik, ...
Rheumatology international 32 (2), 387-393, 2012
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
D Olagnier, AM Brandtoft, C Gunderstofte, NL Villadsen, C Krapp, ...
Nature communications 9 (1), 1-13, 2018
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
AL Hansen, GJ Buchan, M Rühl, K Mukai, SR Salvatore, E Ogawa, ...
Proceedings of the National Academy of Sciences 115 (33), E7768-E7775, 2018
Toll‐like receptor 2 and 4 induced interleukin‐19 dampens immune reactions and associates inversely with spondyloarthritis disease activity
TW Kragstrup, T Andersen, C Holm, B Schiøttz‐Christensen, AG Jurik, ...
Clinical & Experimental Immunology 180 (2), 233-242, 2015
Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections
SK Kratholm, MB Iversen, L Reinert, SK Jensen, M Hokland, T Andersen, ...
PloS one 8 (12), 2013
NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection
MB Iversen, SK Jensen, AL Hansen, H Winther, S Issazadeh-Navikas, ...
Immunobiology 220 (6), 762-768, 2015
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