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Christina R Tysoe
Christina R Tysoe
Verified email at psu.edu
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Cited by
Year
The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif
LK Williams, X Zhang, S Caner, C Tysoe, NT Nguyen, J Wicki, ...
Nature chemical biology 11 (9), 691-696, 2015
1412015
Rapid assembly of a library of lipophilic iminosugars via the thiol–ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease
ED Goddard-Borger, MB Tropak, S Yonekawa, C Tysoe, DJ Mahuran, ...
Journal of medicinal chemistry 55 (6), 2737-2745, 2012
882012
Rapid discovery of potent and selective glycosidase-inhibiting de novo peptides
SAK Jongkees, S Caner, C Tysoe, GD Brayer, SG Withers, H Suga
Cell chemical biology 24 (3), 381-390, 2017
672017
Substrate-Triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA
B Zhang, LJ Rajakovich, D Van Cura, EJ Blaesi, AJ Mitchell, CR Tysoe, ...
Journal of the American Chemical Society 141 (37), 14510-14514, 2019
482019
Potent human α-amylase inhibition by the β-defensin-like protein helianthamide
C Tysoe, LK Williams, R Keyzers, NT Nguyen, C Tarling, J Wicki, ...
ACS central science 2 (3), 154-161, 2016
472016
A Peroxodiiron(III/III) Intermediate Mediating Both N-Hydroxylation Steps in Biosynthesis of the N-Nitrosourea Pharmacophore of Streptozotocin by the Multi …
MJ McBride, D Sil, TL Ng, AM Crooke, GE Kenney, CR Tysoe, B Zhang, ...
Journal of the American Chemical Society 142 (27), 11818-11828, 2020
362020
Fluorinated mechanism-based inhibitors: common themes and recent developments
C Tysoe, S G Withers
Current Topics in Medicinal Chemistry 14 (7), 865-874, 2014
302014
Alpha-glucosidase and alpha-amylase inhibiting thiodiketopiperazines from the endophytic fungus Setosphaeria rostrata isolated from the medicinal plant Costus speciosus in Sri …
RM Centko, PB Ratnaweera, C Tysoe, SG Withers, ED de Silva, ...
Phytochemistry letters 22, 76-80, 2017
252017
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β …
M Thonhofer, P Weber, AG Santana, C Tysoe, R Fischer, BM Pabst, ...
Carbohydrate research 429, 71-80, 2016
242016
Folding then binding vs folding through binding in macrocyclic peptide inhibitors of human pancreatic α-amylase
L Goldbach, BJA Vermeulen, S Caner, M Liu, C Tysoe, L van Gijzel, ...
ACS chemical biology 14 (8), 1751-1759, 2019
232019
A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols
M Schalli, P Weber, C Tysoe, BM Pabst, M Thonhofer, E Paschke, ...
Bioorganic & medicinal chemistry letters 27 (15), 3431-3435, 2017
202017
Concise synthesis of C-1-cyano-iminosugars via a new Staudinger/aza Wittig/Strecker multicomponent reaction strategy
M Zoidl, B Müller, A Torvisco, C Tysoe, M Benazza, A Siriwardena, ...
Bioorganic & Medicinal Chemistry Letters 24 (12), 2777-2780, 2014
192014
The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics
M Zoidl, AG Santana, A Torvisco, C Tysoe, A Siriwardena, SG Withers, ...
Carbohydrate Research 429, 62-70, 2016
162016
Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
CR Tysoe, S Caner, MB Calvert, A Win-Mason, GD Brayer, SG Withers
Chemical Science 10 (48), 11073-11077, 2019
122019
Structural dissection of Helianthamide reveals the basis of its potent inhibition of human pancreatic α-Amylase
C Tysoe, SG Withers
Biochemistry 57 (37), 5384-5387, 2018
122018
C-5a-substituted validamine type glycosidase inhibitors
M Schalli, A Wolfsgruber, AG Santana, C Tysoe, R Fischer, AE Stütz, ...
Carbohydrate research 440, 1-9, 2017
82017
Mechanistic insights into the chaperoning of human lysosomal-galactosidase activity: highly functionalized aminocyclopentanes and C-5a-substituted derivatives of 4-epi-Isofagomine
P Weber, M Thonhofer, S Averill, GJ Davies, AG Santana, P Müller, ...
Molecules 25 (17), 4025, 2020
72020
N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant
M Schalli, C Tysoe, R Fischer, BM Pabst, M Thonhofer, E Paschke, ...
Carbohydrate research 443, 15-22, 2017
72017
A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors
R Lebl, M Thonhofer, C Tysoe, BM Pabst, M Schalli, P Weber, E Paschke, ...
Carbohydrate research 442, 31-40, 2017
72017
Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans
AG Santana, C Tysoe, G Hu, J Kronstad, ED Goddard‐Borger, SG Withers
Chembiochem 18 (3), 284-290, 2017
52017
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