Christopher Francklyn
Christopher Francklyn
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Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites
SA Scaringe, C Francklyn, N Usman
Nucleic acids research 18 (18), 5433-5441, 1990
Aminoacylation of RNA minihelices with alanine
C Francklyn, P Schimmel
Nature 337 (6206), 478-481, 1989
Genetic mapping and exome sequencing identify variants associated with five novel diseases
EG Puffenberger, RN Jinks, C Sougnez, K Cibulskis, RA Willert, ...
PloS one 7 (1), e28936, 2012
Transfer RNA–mediated editing in threonyl-tRNA synthetase: the class II solution to the double discrimination problem
AC Dock-Bregeon, R Sankaranarayanan, P Romby, J Caillet, M Springer, ...
Cell 103 (6), 877-884, 2000
Arabinose-induced binding of AraC protein to araI2 activates the araBAD operon promoter
N Lee, C Francklyn, EP Hamilton
Proceedings of the National Academy of Sciences 84 (24), 8814-8818, 1987
Transfer RNA and human disease
JA Abbott, CS Francklyn, SM Robey-Bond
Frontiers in genetics 5, 158, 2014
Crystal structure of histidyl‐tRNA synthetase from Escherichia coli complexed with histidyl‐adenylate.
JG Arnez, DC Harris, A Mitschler, B Rees, CS Francklyn, D Moras
The EMBO journal 14 (17), 4143-4155, 1995
Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase
R Sankaranarayanan, AC Dock-Bregeon, B Rees, M Bovee, J Caillet, ...
Nature structural biology 7 (6), 461-465, 2000
An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis
M Sissler, C Delorme, J Bond, SD Ehrlich, P Renault, C Francklyn
Proceedings of the National Academy of Sciences 96 (16), 8985-8990, 1999
Enzymatic aminoacylation of an eight-base-pair microhelix with histidine.
C Francklyn, P Schimmel
Proceedings of the National Academy of Sciences 87 (21), 8655-8659, 1990
Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices
C Francklyn, JP Shi, P Schimmel
Science 255 (5048), 1121-1125, 1992
Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases
CS Francklyn, EA First, JJ Perona, YM Hou
Methods 44 (2), 100-118, 2008
Distinct kinetic mechanisms of the two classes of aminoacyl-tRNA synthetases
CM Zhang, JJ Perona, K Ryu, C Francklyn, YM Hou
Journal of molecular biology 361 (2), 300-311, 2006
The aminoacyl-tRNA synthetases
M Ibba, C Francklyn, S Cusack
Landes bioscience, 2005
Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation.
C Francklyn, JJ Perona, J Puetz, YM Hou
Rna 8 (11), 1363-1372, 2002
The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase
JG Arnez, JG Augustine, D Moras, CS Francklyn
Proceedings of the National Academy of Sciences 94 (14), 7144-7149, 1997
The tRNA‐binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation
H Qiu, J Dong, C Hu, CS Francklyn, AG Hinnebusch
The EMBO journal 20 (6), 1425-1438, 2001
Standardizing analysis of circulating microRNA: clinical and biological relevance
NH Farina, ME Wood, SD Perrapato, CS Francklyn, GS Stein, JL Stein, ...
Journal of cellular biochemistry 115 (5), 805-811, 2014
Kinetic discrimination of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA synthetase
EC Guth, CS Francklyn
Molecular cell 25 (4), 531-542, 2007
Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis
TF Williams, AC Mirando, B Wilkinson, CS Francklyn, KM Lounsbury
Scientific reports 3 (1), 1-7, 2013
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